3-Aminobenzeneboronic acid hemisulfate salt
- CAS No.
- 66472-86-4
- Chemical Name:
- 3-Aminobenzeneboronic acid hemisulfate salt
- Synonyms
- 3-AMINOPHENYLBORONIC ACID HEMISULFATE;M-APBA;SKL266;3-Aminobenzeneboroni;boronic acid hemisuL;M-AMINOPHENYLBORIC ACID HEMISULFATE;(3-aminophenyl)-boronic aci sulfate;aminophenylboronic acid hemisulfate;3-aminophenylboric acid hemisulphate;M-AMINOPHENYLBORONIC ACID HEMISULFATE
- CBNumber:
- CB0357728
- Molecular Formula:
- C12H18B2N2O8S
- Molecular Weight:
- 371.96692
- MOL File:
- 66472-86-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/4/23 13:52:06
| Melting point | ≥300 °C |
|---|---|
| storage temp. | Inert atmosphere,2-8°C |
| Water Solubility | Soluble in water |
| form | Crystalline Powder |
| color | White to slightly beige |
| Sensitive | Hygroscopic |
| BRN | 8094151 |
| InChIKey | XMVGYYBQCXVVHU-UHFFFAOYSA-N |
| CAS DataBase Reference | 66472-86-4 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 3-10 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29310095 | |||||||||
| NFPA 704 |
|
3-Aminobenzeneboronic acid hemisulfate salt price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | A71751 | 3-Aminophenylboronic acid hemisulfate salt ≥95% | 66472-86-4 | 5G | ₹7220.28 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A71751 | 3-Aminophenylboronic acid hemisulfate salt ≥95% | 66472-86-4 | 25G | ₹26694.45 | 2022-06-14 | Buy |
| TCI Chemicals (India) | A1774 | 3-Aminophenylboronic Acid Hemisulfate | 66472-86-4 | 1G | ₹2800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | A1774 | 3-Aminophenylboronic Acid Hemisulfate | 66472-86-4 | 5G | ₹7100 | 2022-05-26 | Buy |
| TCI Chemicals (India) | A1774 | 3-Aminophenylboronic Acid Hemisulfate | 66472-86-4 | 25G | ₹17500 | 2022-05-26 | Buy |
3-Aminobenzeneboronic acid hemisulfate salt Chemical Properties,Uses,Production
Chemical Properties
White to slightly beige crystalline powder
Uses
3-Aminobenzeneboronic acid hemisulfate salt is a boronic acid derivative, which can be used as an intermediate in pharmaceutical synthesis. Adsorbent additive for the chromatographic separation of 3'-terminal polynucleotides from RNA.
Application
3-Aminophenylboronic acid hemisulfate salt is used in the synthesis of:
Phenylboronic acid-functionalized inverse opal hydrogels within microfluidic flow cells for glucose sensing.
Phenylboronic acid-salicylhydroxamic acid-derived complexing reagent for protein immobilization on chromatographic support.
It can also be used in the preparation of phenylboronic acid (PBA) monolayer-modified Au electrode for the voltammetric sensing of uridine and cytidine.
Preparation
3-Aminobenzeneboronic acid hemisulfate salt synthesis: Benzenamine, 3-bromo-N-(diphenylmethylene)- (80,0 g; 0.24 moles) was added to the cryogenic reactor along with 1.4 equivalents of triisopropyl borate and dissolved in tetrahydrofuran. The resulting solution was cooled to -80°C under an inert atmosphere and 1.35 equivalents of n-butyllithium (as a solution in n-hexane) was added maintaining the internal temperature. When complete conversion was achieved, the reaction mixture was added to a dilute mixture of sulfuric acid (1 M) and toluene. The layers were separated to obtain an aqueous solution of 3-aminophenylboronic acid hydrogen sulfate (assay yield: 85%). 3-Aminobenzeneboronic acid hemisulfate salt can be obtained by precipitating a 0.5 M aqueous solution at pH 7.2 (pH corrected with 33% aqueous NaOH) at a temperature of 0-5°C. Filtration and drying under vacuum at 40°C for 8 hours yielded 21.7 g of 3-Aminobenzeneboronic acid hemisulfate salt (0.16 moles; 66% molar yield).
3-Aminobenzeneboronic acid hemisulfate salt Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| Sri Neelima Laboratories | +91-7981733602 +91-9849736989 | Telangana, India | 205 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Spectrochem Pvt., Ltd. | 91-22-22016968 | Maharashtra, India | 183 | 58 | Inquiry |
| Reax Chemicals | 08048372701Ext 416 | Hyderabad, India | 4223 | 58 | Inquiry |
| Silica Hetero Cyclics | 08066085877Ext 777 | Hyderabad, India | 120 | 58 | Inquiry |
| Biopharmacule Speciality Chemicals P Ltd (India) | +91 40 6462 1866 | Hyderabad, India | 526 | 58 | Inquiry |
| Spectrochem Private Limited | 08048372608Ext 246 | Maharashtra, India | 1056 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| JSK Chemicals | 58 |
| Sri Neelima Laboratories | 58 |
| A.J Chemicals | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Alfa Aesar | 58 |
| Spectrochem Pvt., Ltd. | 58 |
| Reax Chemicals | 58 |
| Silica Hetero Cyclics | 58 |
| Biopharmacule Speciality Chemicals P Ltd (India) | 58 |
| Spectrochem Private Limited | 58 |
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