1-BROMO-2-BUTYNE
- CAS No.
- 3355-28-0
- Chemical Name:
- 1-BROMO-2-BUTYNE
- Synonyms
- 1-Bromobut-2-yne;2-BUTYNYL BROMIDE;1-Bromobut-2-butyne;1-Brom-2-Butin;1-BROMO-2-BUTYNE;Linagliptin INT4;1-broMo -2-Ding Que;1-Bromo-2-butyne,98%;1-BROMO-2-BUTYNE 98%;1-Bromo-2-butyne >
- CBNumber:
- CB0363349
- Molecular Formula:
- C4H5Br
- Molecular Weight:
- 132.99
- MOL File:
- 3355-28-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/6 17:55:34
| Boiling point | 40-41 °C/20 mmHg (lit.) |
|---|---|
| Density | 1.519 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 97 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Miscible with acetonitrile. |
| form | Liquid |
| Specific Gravity | 1.519 |
| color | Clear pale yellow-greenish |
| BRN | 605306 |
| InChIKey | LNNXOEHOXSYWLD-UHFFFAOYSA-N |
| CAS DataBase Reference | 3355-28-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335-H226 | |||||||||
| Precautionary statements | P261-P303+P361+P353-P305+P351+P338-P405-P501a-P210-P233-P240-P241+P242+P243-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P403+P235-P501 | |||||||||
| Risk Statements | 10 | |||||||||
| Safety Statements | 16-24/25 | |||||||||
| RIDADR | UN 1993 3/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-23 | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29033990 | |||||||||
| NFPA 704 |
|
1-BROMO-2-BUTYNE price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 427292 | 1-Bromo-2-butyne ≥98% | 3355-28-0 | 1G | ₹5163.53 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 427292 | 1-Bromo-2-butyne ≥98% | 3355-28-0 | 5G | ₹19820.58 | 2022-06-14 | Buy |
| TCI Chemicals (India) | B2190 | 1-Bromo-2-butyne min. 96.0 % | 3355-28-0 | 1G | ₹2200 | 2022-05-26 | Buy |
| TCI Chemicals (India) | B2190 | 1-Bromo-2-butyne min. 96.0 % | 3355-28-0 | 5G | ₹7500 | 2022-05-26 | Buy |
1-BROMO-2-BUTYNE Chemical Properties,Uses,Production
Chemical Properties
Clear pale yellow-greenish liquid
Uses
1-Bromo-2-butyne is used in the preparation of six to eight annulated ring compounds in reaction with indoles and pseudopterane (+/-)-Kallolide B, which is a marine natural product. Further, it acts as a precursor in the preparation of axially chiral teranyl compounds, alkylation of L-tryptophan methyl ester, 4-butynyloxybenzene sulfonyl chloride and mono-propargylated diene derivative. In addition to this, it is also used in the synthesis of isopropylbut-2-ynylamine, allenylcyclobutanol derivatives, allyl-[4-(but-2-ynyloxy)phenyl]sulfane, allenylindium and axially chiral teranyl compounds.
Preparation
1-bromo-2-butyne is obtained by reacting 2-butyn-1-ol and organic solvent, pyridine.First react bromoethane with metal magnesium in THF to prepare Grignard reagent, then add paraformaldehyde to Grignard reagent for Grignard reaction, separate and recover after Grignard reaction 2-butyn-1-ol, then mix 2-butyn-1-ol with organic solvent and pyridine, add phosphorus tribromide dropwise for bromination reaction, separate and recover the product after bromination reaction.
General Description
1-Bromo-2-butyne is a propargyl bromide derivative. It is one of the constitutional isomer of bromo butyne. Its Br-loss threshold photoionization breakdown diagram has been analyzed to derive dissociative photoionization thresholds to C4H5+ production. It participates in the preparation of linagliptin.
1-BROMO-2-BUTYNE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| BTC pharm India | +918790379245 | AndhraPradesh, India | 1269 | 58 | Inquiry |
| Srisyn Labs | +91-9705168728 +91-9705168728 | Hyderabad, India | 45 | 58 | Inquiry |
| Allchem Lifescience Pvt. Ltd | +919867655500 | Gujarat, India | 971 | 58 | Inquiry |
| Nasense Labs Private Limited | +91-9154030322 +91-9701368505 | Hyderabad, India | 47 | 58 | Inquiry |
| Stereokem Pvt Ltd | +91-4029706929 +91-9394224843 | Telangana, India | 350 | 58 | Inquiry |
| PSN Medicare Private Limited | +91-9030090313 +91-7702388996 | Telangana, India | 82 | 58 | Inquiry |
| Jubilant Ingrevia | +91-1204361000 +91-1204361000 | Uttar Pradesh, India | 142 | 58 | Inquiry |
| Jaydev Chemicals Industries | +91-7400455010 +91-9820034025 | Maharashtra, India | 34 | 58 | Inquiry |
| Navone Specialties (OPC) Pvt Ltd | +91-9323789882 +91-9323789882 | Maharashtra, India | 144 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| BTC pharm India | 58 |
| Srisyn Labs | 58 |
| Allchem Lifescience Pvt. Ltd | 58 |
| Nasense Labs Private Limited | 58 |
| Stereokem Pvt Ltd | 58 |
| PSN Medicare Private Limited | 58 |
| Jubilant Ingrevia | 58 |
| Jaydev Chemicals Industries | 58 |
| Navone Specialties (OPC) Pvt Ltd | 58 |
| Pharma Affiliates | 58 |
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