5-Aminolevulinic acid hydrochloride
- CAS No.
- 5451-09-2
- Chemical Name:
- 5-Aminolevulinic acid hydrochloride
- Synonyms
- 5-Ala;5-AMINOLEVULINIC ACID HCL;5-Aminolevulinic;inic acid hydrochL;5-AMINO-4-OXOPENTANOIC ACID HYDROCHLORIDE;evuL;Gliolan;5-AminoL;DELTA-AMINOLEVULINIC ACID HYDROCHLORIDE;ALA-PDT
- CBNumber:
- CB0496757
- Molecular Formula:
- C5H10ClNO3
- Molecular Weight:
- 167.59
- MOL File:
- 5451-09-2.mol
- Modify Date:
- 2024/7/5 19:37:52
| Melting point | ~150 °C (dec.) |
|---|---|
| Flash point | 155-157°C |
| storage temp. | -20°C |
| solubility | H2O: 50 mg/mL |
| form | powder |
| color | White to pale yellow |
| PH | pH (10g/l, 25℃) : 2.5～3.0 |
| Water Solubility | Soluble in dimethyl sulfoxide, methanol and water. |
| Decomposition | 155-157 ºC |
| Sensitive | Hygroscopic |
| Merck | 14,446 |
| BRN | 3690651 |
| Stability | Hygroscopic |
| InChIKey | ZLHFONARZHCSET-UHFFFAOYSA-N |
| CAS DataBase Reference | 5451-09-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-66-20/21/22-36/38 | |||||||||
| Safety Statements | 26-36/37-37/39-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | OI1640000 | |||||||||
| F | 3-8-10 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29224999 | |||||||||
| NFPA 704 |
|
5-Aminolevulinic acid hydrochloride price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | A7793 | 5-Aminolevulinic acid hydrochloride BioReagent, suitable for cell culture, powder, ≥98% | 5451-09-2 | 10MG | ₹2749.55 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A7793 | 5-Aminolevulinic acid hydrochloride BioReagent, suitable for cell culture, powder, ≥98% | 5451-09-2 | 500MG | ₹15144.18 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR2993 | Aminolevulinic Acid Hydrochloride pharmaceutical secondary standard, certified reference material | 5451-09-2 | 500MG | ₹17038.55 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A7793 | 5-Aminolevulinic acid hydrochloride BioReagent, suitable for cell culture, powder, ≥98% | 5451-09-2 | 1G | ₹29812.05 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A3785 | 5-Aminolevulinic acid hydrochloride ≥98% | 5451-09-2 | 500MG | ₹17547.33 | 2022-06-14 | Buy |
5-Aminolevulinic acid hydrochloride Chemical Properties,Uses,Production
Description
5-Aminolevulinic acid hydrochloride (5-ALA) is a naturally occurring amino acid that is an intermediate in the biosynthesis of chlorophyll and haemoglobin. It has anti-inflammatory, antioxidant and antitumour activities, and 5-Aminolevulinic acid hydrochloride-mediated sonodynamic therapy (SDT) has antitumour effects on pancreatic cancer cells. In addition, it is a visualising agent that causes high-grade gliomas to fluoresce under blue light, which can help guide surgeons in removing tumours and is considered a useful imaging tool for brain tumour resection.
Chemical Properties
white to pale yellow crystals or
Uses
5-Aminolevulinic acid hydrochloride finds an important role as a precursor in the synthesis of tetrapyrroles such as chlorophyll and heme. It is widely utilized in photodynamic therapy of diseases namely, Paget?s disease and human papillomavirus (HPV) infection-associated cervical condylomata acuminata.
Definition
ChEBI: A hydrochloride that is the monohydrochloride of 5-aminolevulinic acid. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used in combination with blue light illumination for the treatment of minimally to moderat ly thick actinic keratosis of the face or scalp.
Application
5-Aminolevulinic acid hydrochloride has been used to activate or inhibit heme biosynthesis in HeLa and K562 cell lines. It has also been used in photodynamic therapy in mice with A431 tumours. Clinical oral administration of 5-Aminolevulinic acid hydrochloride potentiates the antihypertensive effects associated with anaesthetics and is used in the treatment of hypertensive patients, particularly in elderly hypertensive patients receiving antihypertensive medications[1-2].
Purification Methods
Dry ALA-HCl in a vacuum desiccator over P2O5 overnight, then crystallise it by dissolving it in cold EtOH and adding dry Et2O. Also crystallis
References
[1] Oral Aminolevulinic Acid Hydrochloride[J]. Definitions, 2020. DOI:10.32388/vh56ni.
[2] NOBORU FUKUDA . 5-Aminolevulinic acid hydrochloride enhances bupivacaine-induced hypotension in spontaneously hypertensive rats[J]. Journal of pharmacological sciences, 2023. DOI:10.1016/j.jphs.2023.02.007.
5-Aminolevulinic acid hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4317 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
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