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Clobetasone butyrate

Clobetasone butyrate Structure
CAS No.
25122-57-0
Chemical Name:
Clobetasone butyrate
Synonyms
eumovate;Clobetasone-17-butyrate;sn203;Emovate;CCl 5537;molivate;GR 2/1214;Kindavate;(16-beta)-);17-Butyrate
CBNumber:
CB0497976
Molecular Formula:
C26H32ClFO5
Molecular Weight:
478.98
MOL File:
25122-57-0.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:54:58

Clobetasone butyrate Properties

Melting point 90-100°
Boiling point 573.3±50.0 °C(Predicted)
Density 1.1736 (estimate)
storage temp. Refrigerator, Under Inert Atmosphere
solubility Practically insoluble in water, freely soluble in acetone and in methylene chloride, slightly soluble in ethanol (96 per cent).
form Solid
color White to Off-White
Stability Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey FBRAWBYQGRLCEK-JGSYYNBSNA-N
SMILES [C@]1(C(=O)CCl)(OC(=O)CCC)[C@@H](C)C[C@@]2([H])[C@]3([H])CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)C(=O)C[C@]12C |&1:0,11,14,16,26,28,33,r|
CAS DataBase Reference 25122-57-0(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS08
Signal word  Warning
Hazard statements  H351
Precautionary statements  P280
Hazard Codes  Xn
Risk Statements  40
Safety Statements  22-36
WGK Germany  3
RTECS  TU4154083
HS Code  29372290
Toxicity mouse,LD50,intraperitoneal,500mg/kg (500mg/kg),Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 838, 1983.
NFPA 704
0
1 0

Clobetasone butyrate price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) C5548 Clobetasone butyrate ≥98% 25122-57-0 100MG ₹5899.63 2022-06-14 Buy
TCI Chemicals (India) C3510 Clobetasone Butyrate 25122-57-0 50MG ₹1800 2022-05-26 Buy
TCI Chemicals (India) C3510 Clobetasone Butyrate 25122-57-0 250MG ₹4600 2022-05-26 Buy
TCI Chemicals (India) C3510 Clobetasone Butyrate 25122-57-0 1G ₹8000 2022-05-26 Buy
Product number Packaging Price Buy
C5548 100MG ₹5899.63 Buy
C3510 50MG ₹1800 Buy
C3510 250MG ₹4600 Buy
C3510 1G ₹8000 Buy

Clobetasone butyrate Chemical Properties,Uses,Production

Chemical Properties

White or almost white powder.

Uses

Clobetasone butyrate is a synthetic glucocorticoid which is used as an anti-inflammatory in the treatment of various skin disorders. As a steroid medicine, it can used on the skin to treat swelling, itching and irritation. Such as eczema, including ;contact dermatitis; psoriasis; insect bites and stings; nappy rash.

Mechanism of action

Topical corticosteroids (Clobetasone butyrate) inhibit the migration of macrophages and leukocytes into areas of inflamed skin by reversing vascular dilation and permeability, resulting in decreased erythema, edema and pruritus.

Side effects

Some people get a burning or stinging feeling for a few minutes when they put clobetasone cream or ointment on their skin. Clobetasone cream contains cetostearyl alcohol and chlorocresol, which may cause local skin reactions or allergic reactions.

Clobetasone butyrate Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 166)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Halcyon Labs Pvt. Ltd +919833750169 Mumbai, India 17 58 Inquiry
Gonane Pharma +91-9819380043 +91-9819380043 NaviMumbai, India 192 58 Inquiry
Anuh Pharma Ltd (SK GROUP) +912266227575 Maharashtra, India 38 58 Inquiry
Horster Biotek Pvt Ltd +91-7359657360 +91-9898127219 Gujarat, India 58 58 Inquiry
Dayaram Pharma Chem +91-9601766800 +91-9601766800 Gujarat, India 61 58 Inquiry
Stermone Chemicals Pvt Ltd +91-9328939700 +91-9328939700 Gujarat, India 20 58 Inquiry
Avik Pharmaceutical Limited +91-9821827247 +91-7600019006 Maharashtra, India 22 58 Inquiry
Bhugan Lifescience Pvt Ltd +91-9909430337 +91-8849461798 Gujarat, India 23 58 Inquiry
Unimax Chemicals Pvt Ltd +91-9819363200 +91-9963474090 Maharashtra, India 21 58 Inquiry
Medilink Pharmachem +91 (79) 3007-0133 New Delhi, India 424 50 Inquiry

Clobetasone butyrate Spectrum

(16-beta)-) 11,20-trione,21-chloro-9-fluoro-17-hydroxy-16-beta-methyl-pregna-4-diene-3 21-chloro-9-fluoro-17-hydroxy-16-beta-methylpregna-1,4-diene,3,11,20-trione molivate pregna-1,4-diene-3,11,20-trione,21-chloro-9-fluoro-16-methyl-17-(1-oxobutoxy sn203 21-chloro-9-fluoro-17-hydroxy-16beta-methylpregna-1,4-diene-3,11,20-trione 17-butyrate ClobetasolPropionate-Bp/Ep/Usp Butyric acid, ester with 21-chloro-9-fluoro-17-hydroxy-16β-methylpregna-1,4-diene-3,11,20-trione (8CI) CCl 5537 Emovate GR 2/1214 Kindavate Pregna-1,4-diene-3,11,20-trione, 21-chloro-9-fluoro-16-methyl-17-(1-oxobutoxy)-, (16β)- Pregna-1,4-diene-3,11,20-trione, 21-chloro-9-fluoro-17-hydroxy-16β-methyl-, butyrate (8CI) 21-Chloro-9-fluoro-17-hydroxy-16b-methylpregna-1,4-diene-3,11,20-trione 17-butyrate Clobetasone butyrate CLOBETASOLE BUTYRATE 21-Chloro-9-fluoro-16β-methyl-17-(1-oxobutoxy)pregna-1,4-diene-3,11,20-trione 21-Chloro-9-fluoro-17-hydroxy-16β-methylpregna-1,4-diene-3,11,20-trione=butyrate [(8S,9R,10S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-10,13,16-trimethyl-3,11-dioxo-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-17-yl] butanoate [(8S,9R,10S,13S,14S,16S,17R)-17-(2-chloroethanoyl)-9-fluoro-10,13,16-trimethyl-3,11-dioxo-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-17-yl] butanoate butyric acid [(8S,9R,10S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-3,11-diketo-10,13,16-trimethyl-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-17-yl] ester 17-Butyrate )-pregn-5-en-20-one 3,17-Dihydroxy-16-methyl-(3&beta )-3,17-Dihydroxy-2-(1-piperidinyl)androstan-16-yl]-1-methyl|piperidinium Bromide )-16-Methyl-17,20:20,21-bis[methylenebis(oxy)]-pregna-1,4-diene-3,11-dione )-3-(Acetyloxy)-17-hydroxy-2-(1-piperidinyl)androstan-16-yl]-1-methylpiperidinium Bromide-d3 -Hydroxytestosterone )-11-Hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-pregna-1,4-diene-3,20-dione )-17-Acetyloxy-3-hydroxy-2-(1-piperidinyl)androstan-16-yl]-1-methylpiperidinium Bromide )-16-Methyl-17,21-bis(1-oxopropoxy)pregna-1,4,9(11)-triene-3,20-dione 20R)-9-Fluoro-11,20-dihydroxy-16-methyl-3-oxopregna-1,4-dien-21-oic Acid|(Betamethasone Impurity) )-3-(Acetyloxy)-17-hydroxy-2-(1-piperidinyl)androstan-16-yl]-1-methylpiperidinium Bromide -Hydroxy Stanozolol H-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione|(Deflazacort Impurity) )-9-Fluoro-11,17,21-trihydroxy-16-methylpregn-4-ene-3,20-dione )-17,21-Bis(acetyloxy)-16-methyl-pregna-1,4,9(11)-triene-3,20-dione -Hydroxy-17-epi-norethisterone H-Pregna-1,4-dieno[17,16-d]oxazole-3,11,20-trione -Hydroxymestanolone )-6-Bromo-9-fluoro-11,17-dihydroxy-16-methyl-21-[(1-oxopentyl)oxy]-pregna-1,4-diene-3,20-dione Clonazepam impurity B CRS Clobetasone butyrate for system suitability CRS Clobetasone butyrate CRS Clobetasone butyrate solution in Acetonitrile,100μg/mL Clobetasone ButyrateQ: What is Clobetasone Butyrate Q: What is the CAS Number of Clobetasone Butyrate Q: What is the storage condition of Clobetasone Butyrate 4-(methylamino)-3-nitro- eumovate Clobetasone-17-butyrate 21-chloro-9-fluoro-16β-methyl-3,11,20-trioxopregna-1,4-dien-17-ylbutanoate Simvastatin Impurity 44 Betamethasone Butyrate/Clobetamethasone Butyrate 25122-57-0 C26H32ClFO5 Intermediates & Fine Chemicals Pharmaceuticals