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Clobetasol

Clobetasol Structure
CAS No.
25122-41-2
Chemical Name:
Clobetasol
Synonyms
CLOBETASOLE PROPIONATE;CLOBETASOL-17-PROPIONATE;Clobetasol;ClobetasolBase;Clobetasol USP/EP/BP;Clobetasol Impurity G;CLOBESTASOL PROPIONATE;Betamethasone Impurity B;Clobetasol impurity G (PhEur);Clobetasol Propionate EP IMP G
CBNumber:
CB8715108
Molecular Formula:
C22H28ClFO4
Molecular Weight:
410.91
MOL File:
25122-41-2.mol
Modify Date:
2024/4/1 18:08:31

Clobetasol Properties

Melting point 220-222°C
Boiling point 555.1±50.0 °C(Predicted)
Density 1.32±0.1 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility Acetone (Slightly), DMSO (Slightly), Methanol (Slightly)
form Solid
pka 12.03±0.70(Predicted)
color White to Light Brown

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H360Df-H373-H413
Precautionary statements  P201-P308+P313
Hazard Codes  T
Risk Statements  61-48/20/21-53-62
Safety Statements  53-36/37-45

Clobetasol Chemical Properties,Uses,Production

Chemical Properties

White to Off-White Solid

Uses

Clobetasol (Clobetasol Propionate EP Impurity G) is a topical corticosteroid. Glucocorticoid; anti-inflammatory.

Definition

ChEBI: A 3-oxo-Delta1,Delta4-steroid that is 16beta-methylpregna-1,4-diene-3,20-dione bearing hydroxy groups at the 11beta and 17alpha posit ons, fluorine at position 9, and a chlorine substituent at position 21. It is used as its 17alpha-propionate ester to treat various skin disorders, including exzema and psoriasis.

Clobetasol Preparation Products And Raw materials

Raw materials

Preparation Products

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ClobetasolBase Clobetasol Propionate 25122-46-7 / Base 21-Chloro-9-fluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione CLOBESTASOL PROPIONATE Clobetasol (Betamethasone Impurity B) (11β,16β)-21-Chloro-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione Clobetasol impurity G (PhEur) 17-(2-Chloroacetyl)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8, 11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one Clobetasol Clobetasol Propionate Impurity 7(Clobetasol Propionate EP Impurity G) Clobetasol (Betamethasone EP Impurity B) Clobetasol Propionate EP Impurity G Clobetasol Impurity G Betamethasone Impurity 2(Betamethasone EP Impurity B) Betamethasone impurity 1/Betamethasone EP Impurity B/Clobetasol/21-Chloro-9-fluoro-11?,17-dihydroxy-16?-methylpregna-1,4-diene-3,20-dione Clobetasol Propionate EP IMP G 21-Chloro-9-fluoro-11beta,17-dihydr Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11,17-dihydroxy-16-methyl-, (11β,16β)- Clobetasol Propionate EP Impurity G/Betamethasone EP Impurity B Clobetasol USP/EP/BP Clobetasol (1.0 mg/mL in Methanol) Betamethasone Impurity B Betamethasone Impurity B (EP)/ Clobetasol Propionate Impurity-G (EP) Clobetasol Propionate Impurity-G (EP)/ Betamethasone Impurity B (EP) Clobetasol D5Q: What is Clobetasol D5 Q: What is the CAS Number of Clobetasol D5 Q: What is the storage condition of Clobetasol D5 Q: What are the applications of Clobetasol D5 21-Chloro-9-fluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione CLOBETASOLE PROPIONATE CLOBETASOL-17-PROPIONATE (8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one Clobetasol Propionate Impurity G Betamethasone EP Impurity B(Clobetasol Propionate EP Impurity G) Clobetasol (Betamethasone EP Impurity B, Clobetasol Propionate EP Impurity G) 1, 4-PREGNADIEN-21-CHLORO-9α-FLUORO-16β-METHYL-11β, 17α-DIOL-3, 20-DIONE 21-chloro-9-uoro-11β,17-dihydroxy-16β-methylpregna- 1,4-diene-3,20-dione 25122-41-2 C22H28ClFO4 CI - CL Analytical Standards Alphabetic Analytical Chromatography Product Catalog Intermediates & Fine Chemicals Pharmaceuticals Steroids