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ChemicalBook > Product Catalog >Pharmaceutical intermediates >Bulk Drug Intermediates >9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Structure
CAS No.
981-34-0
Chemical Name:
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
Synonyms
DB11;(9β,11β,16β)-;Einecs 213-563-4;9beta,11beta-Epoxy-1;11beta-Epoxy-17alpha;Betamethasone epoxide;16-beta Methyl Epoxid;16-BETA METHYL EPOXIDE;DB11(16β-Methyl Epoide);DB11(16B-Methyl Epoide)
CBNumber:
CB72129663
Molecular Formula:
C22H28O5
Molecular Weight:
372.45
MOL File:
981-34-0.mol
MSDS File:
SDS
Modify Date:
2023/11/3 16:33:47
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9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Properties

Melting point 210-220 ºC
Boiling point 564.9±50.0 °C(Predicted)
Density 1.32±0.1 g/cm3(Predicted)
vapor pressure 0-357.304Pa at 25℃
storage temp. Refrigerator
solubility Chloroform (Slightly, Heated), Dioxane (Slightly, Heated), DMSO (Slightly, Heated)
form Solid
pka 12.56±0.70(Predicted)
color White to Light Beige
InChIKey GBDXNHBVYAMODG-OBDZOPJXNA-N
SMILES C[C@]12C=CC(=O)C=C1CC[C@@]1([H])[C@]3([H])C[C@H](C)[C@](O)(C(=O)CO)[C@@]3(C)C[C@@H]3O[C@]213 |&1:1,10,12,15,17,23,26,28,r|

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Chemical Properties,Uses,Production

Description

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione (Betamethasone EP Impurity E) is a metabolite of Mometasone Furoate (M490000) which is a tropical corticosteroid used as an anti-inflammatory. Low solubility in most solvent. 9,11β-epoxysteroid compounds can be prepared by 9-position fluorination to obtain dexamethasone. By modifying its 3-bit, 6-bit, 16-bit, and 21-bit, a series of drugs can be prepared.

Chemical Properties

Off-White Solid

Uses

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione is a metabolite of Mometasone furoate. It has low solubility in most solvents.

Preparation

Add sodium sulfite and sodium hydroxide to water, stir to dissolve, and then add methanol. The raw material was added for hydrolysis reaction. After the reaction for 3h, glacial acetic acid was added to adjust the pH=6~8. The water was added to the solution and crystallize at 0 ℃. Finally, 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione was obtained after purification.
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Preparation Products And Raw materials

Raw materials

Preparation Products

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Suppliers

Global( 229)Suppliers
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OPULENT PHARMA +91-9106692785 +91-9106692785 Gujarat, India 479 58 Inquiry
CLEANCHEM LABORATORIES LLP +91-9951015911 +91-9951015911 Mumbai, India 281 58 Inquiry
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CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
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OPULENT PHARMA 58
CLEANCHEM LABORATORIES LLP 58
JIVICHEM SYNTHESIS PVT LTD 58
SynThink RESEARCH CHEMICALS 58
GLP Pharma Standards 58
Molsyns Research 58
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
SynZeal Research Pvt Ltd 58

981-34-0(9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione )Related Search:

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BETAMETHASONE DIPROPIONATE MM(CRM STANDARD) Betamethasone Methyl acrylate
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16-BETA METHYL EPOXIDE 9beta,11beta-epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione (9β)-9,11β-Epoxy-16β-methyl-17,21-dihydroxypregna-1,4-diene-3,20-dione 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Einecs 213-563-4 Betamethasone 9,11-Epoxide (9β,11β,16β)-9,11-Epoxy-17,21-dihydroxy-16-Methylpregna-1,4-diene-3,20-dione (9β,11β,16β)- 9beta,11beta-Epoxy-1 DB11(16B-Methyl Epoide) DB11(16β-Methyl Epoide) (4aS,4bS,5aS,6aS,7R,8S,9aS,9bS)-7-Hydroxy-7-(2-hydroxyacetyl)-4a,6a,8-triMethyl-5a,6,6a,7,8,9,9a,9b,10,11-decahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-2(4aH)-one Betamethasone epoxide (4aS,4bS,5aS,6aS,7R,9aS,9bS)-7-Hydroxy-7-(2-hydroxyacetyl)-4a,6a-Dimethyl-8-methylene-5a,6,6a,7,8,9,9a,9b,10,11-decahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-2(4aH)-one Pregna-1,4-diene-3,20-dione,9 17α,21-dihydroxy-9β,11β-epoxy-16β-methylpregna-1,4-diene-3,20-dione Beclomethasone EP Impurity R Betamethasone Impurity 5（Betamethasone EP Impurity E） Beclometasone Dipropionate?EP Impurity R 16-beta Methyl Epoxid 9,11beta-Epoxy-17,21-dihydroxy-16be 9Beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione[DB11] Pregna-1,4-diene-3,20-dione, 9,11-epoxy-17,21-dihydroxy-16-methyl-, (9β,11β,16β)- Beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione Beclomethasone Impurity 6 Beclomethasone propionate EP impurity R Beclomethasone Impurity 15(Beclometasone Dipropionate EP Impurity R) 9-beta,11-beta-epoxy-17-alpha,21-dihydroxy-16-beta-methylene... DB11(16β-Methyl Epoxide) 11beta-Epoxy-17alpha 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione 9,11β-Epoxy-17,21-dihydroxy-16β-methyl-9β-pregna-1,4-diene-3,20-dione DB11 Beclomethasone dipropionate EP Impurity R 9-β,11-β-epoxy-17-α,21-dihydroxy-16-beta-methylenepregna-1,4-diene-3,20-dione Beclometasone Dipropionate Impurity R Beclometasone Propionate EP Impurity R Betamethasone Impurity E Beclometasone Propionate EP Impurity R（Betamethasone EP Impurity E） Beclomethasone Dipropionate EP Impurity R (Betamethasone 9,11-Epoxide) Betamethasone 9,11-Epoxide (Beclomethasone Dipropionate EP Impurity R) Betamethasone epoxy hydrolysate 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregnα-1,4-diene-3,20-dione 9beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-met 93.113-Epoxy-17a,21-dihydroxy-16p -methylenepregna-1.4-diene-3.20-dione(DB11) Beclometasone Dipropionate EP Impurity R (Betamethasone 9,11-Epoxide) (9β,11β,16β)-9,11-Epoxy-17,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione 981-34-0 Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals Steroids 981-34-0