REGADENOSON
- CAS No.
- 313348-27-5
- Chemical Name:
- REGADENOSON
- Synonyms
- Regadenoson monohydrate;CS-1874;REGADENOSON;LEXISCAN; CVT-3146;;CVT-3146|||Lexiscan;Regadenoson Impurity;Regadenoson(CVT-3146);Regadenoson Impurity 16;Regadenoson Impurity 18;Regadenoson Monohydrate (CVT-3146)
- CBNumber:
- CB0501002
- Molecular Formula:
- C15H18N8O5
- Molecular Weight:
- 390.35
- MOL File:
- 313348-27-5.mol
- Modify Date:
- 2023/7/21 14:17:16
| Melting point | 158-160°C |
|---|---|
| Density | 1.98±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) |
| form | Solid |
| pka | 13.07±0.70(Predicted) |
| color | Off-White to Pale Brown |
| CAS DataBase Reference | 313348-27-5 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300-H330-H310 | |||||||||
| Precautionary statements | P260-P271-P284-P304+P340-P310-P320-P403+P233-P405-P501-P262-P264-P270-P280-P302+P350-P310-P322-P361-P363-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501 | |||||||||
| NFPA 704 |
|
REGADENOSON Chemical Properties,Uses,Production
Description
Lexiscan ™(regadenoson) is an injectable adenosine A2A receptor agonist for use as a pharmacologic stress agent in myocardial perfusion imaging (MPI) studies in patients unable to undergo adequate exercise induced stress. Regadenoson is the first adenosine A2A receptor agonist shown to be safe and effective as a pharmacologic stress agent in MPI studies. It is delivered as a rapid bolus (approximately 10 seconds) with no dose adjustment required for body weight. The product was developed under a license and collaboration agreement between CV Therapeutics and Astellas, and was launched by Astellas in June of 2008.
Chemical Properties
Off-White Solid
Uses
Regadenoson is a selective, short-acting adenosine A2A receptor agonist (Ki = 1.1 nM for pig striatum A2A receptor). It increases coronary blood flow 3.4- to 3.8-fold with a half-time to reversal of 1.9-2.6 minutes in open-chest anesthetized pigs. Regadenoson is used to induce hyperemia (increased blood flow), particularly in the context of myocardial perfusion imaging. It has also been found to increase the delivery of compounds to the central nervous system through the blood-brain barrier in animals.
REGADENOSON Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SKVen Technologies Pvt.Ltd. | +91-7032295152 +91-7032295152 | Hyderabad, India | 81 | 58 | Inquiry |
| Mylan Laboratories Ltd | +91-4023550543 +91-4030866666 | Telangana, India | 150 | 58 | Inquiry |
| Apicore Pharmaceuticals Pvt Ltd | +91-2662267177 +91-2662267166 | Gujarat, India | 181 | 58 | Inquiry |
| Gland Pharma Ltd | +91-7075736524 +91-9700602423 | Telangana, India | 44 | 58 | Inquiry |
| Biophore India Pharmaceuticals Pvt Ltd | +91-9100031592 +91-9030907714 | Telangana, India | 134 | 58 | Inquiry |
| MSN LIFE SCIENCES PRIVATE LTD | +91 84523 34200 | New Delhi, India | 104 | 58 | Inquiry |
| Sun Pharmaceutical Industries Ltd. | 91-22-43244324 | Maharashtra, India | 99 | 58 | Inquiry |
| GLAND PHARMA LTD | +91-40-30510999 | New Delhi, India | 52 | 58 | Inquiry |
| SUN PHARMACEUTICAL INDUSTRIES LTD | (+91 22) 4324 4324 | New Delhi, India | 175 | 58 | Inquiry |
| MYLAN API US LLC | 080 6672 8000 | New Delhi, India | 44 | 58 | Inquiry |