IMD-0354
- CAS No.
- 978-62-1
- Chemical Name:
- IMD-0354
- Synonyms
- IMD 0354;IMD-0354;IMD-0354 USP/EP/BP;IKK-2 INHIBITOR V; IMD 0354;IMD0354;;IKK-2 Inhibitor V - CAS 978-62-1 - Calbiochem;IMD-0354, 99%, a synthetic selective NF-kB inhibitor;Benzamide, N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxy-;IMD0354,IκB kinase,Inhibitor,I kappa B kinase,IKK,inhibit,IMD-0354;N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide IMD0354
- CBNumber:
- CB0503637
- Molecular Formula:
- C15H8ClF6NO2
- Molecular Weight:
- 383.67
- MOL File:
- 978-62-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:54:58
| Boiling point | 323.1±42.0 °C(Predicted) |
|---|---|
| Density | 1.561 |
| storage temp. | -20°C |
| solubility | DMSO (5 mg/ml) or Ethanol (1 mg/ml). |
| form | White solid |
| pka | 7.61±0.43(Predicted) |
| color | White to off-white |
| Sensitive | Light Sensitive |
| CAS DataBase Reference | 978-62-1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| HS Code | 29242990 |
IMD-0354 price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | I3159 | IMD-0354 ≥98% (HPLC), solid | 978-62-1 | 5MG | ₹26835.18 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | I3159 | IMD-0354 ≥98% (HPLC), solid | 978-62-1 | 10MG | ₹45486.65 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 401482 | IKK-2 Inhibitor V - CAS 978-62-1 - Calbiochem The IKK-2 Inhibitor V, also referenced under CAS 978-62-1, controls the biological activity of IKK-2. This small molecule/inhibitor is primarily used | 978-62-1 | 5MG | ₹29850 | 2022-06-14 | Buy |
IMD-0354 Chemical Properties,Uses,Production
Uses
IMD-0354 has been used to study the effect of NF-κB (nuclear factor) inhibition on differentially expressed in chondrocytes 2. It has also been used to study the role of NF-κB signaling in tumor necrosis factor-induced certain transcription factors expression using human primary fibroblasts.
Biological Activity
Inhibitor of I κ B kinase-2 (IKK-2, IKK- β ) that blocks NF- κ B nuclear translocation. Attenuates myocardial ischemia/reperfusion injury by decreasing expression of adhesion molecules ICAM-1 and P-selectin and inhibiting cytokine and chemokine production in cardiomyocytes. Induces G 0 /G 1 cell cycle arrest and apoptosis in HMC-1? and breast cancer cells.
Biochem/physiol Actions
IMD-0354 acts as an inhibitor by inhibiting the phosphorylation of the NF-κB (nuclear factor) and its translocation into the nucleus. It blocks IκBα phosphorylation (IC50 ~ 250 nM). Cardioprotectant, that reduces IL-1β and MCP-1 production (IC50 < 1 μM) in cardiomyocytes. IMD-0354 affects angiogenesis, which has been observed in human umbilical vein endothelial cells. It prevents tube formation and migration of the cells. In vivo studies also prove that IMD-0354 inhibits retinal vessel growth. IMD-0354 also acts as an inhibitor of Aquaporin 4 (AQP4) inhibitor (IC50 0.2μM) with no inhibitory potency to IKK-β. [4]
IMD-0354 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; +8619817745290 | China | 5660 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 26165 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| LEAP CHEM CO., LTD. | +86-852-30606658 | China | 24738 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| A.J Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| ATK CHEMICAL COMPANY LIMITED | 60 |
| BOC Sciences | 58 |
| career henan chemical co | 58 |
| Blocksynth Pharmaceutical Technology Co.,Ltd | 58 |
| Dideu Industries Group Limited | 58 |
| InvivoChem | 58 |
| LEAP CHEM CO., LTD. | 58 |
| TargetMol Chemicals Inc. | 58 |