IMD-0354
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- ₹26835.18 - ₹45486.65
- Product name: IMD-0354
- CAS: 978-62-1
- MF: C15H8ClF6NO2
- MW: 383.67
- EINECS:
- MDL Number:MFCD00218820
- Synonyms:Benzamide, N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxy-;N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide IMD0354;IKK-2 Inhibitor V - CAS 978-62-1 - Calbiochem;IKK-2 INHIBITOR V; IMD 0354;IMD0354;;IMD-0354, 99%, a synthetic selective NF-kB inhibitor;IMD 0354;IMD-0354;IMD-0354 USP/EP/BP;IMD0354,IκB kinase,Inhibitor,I kappa B kinase,IKK,inhibit,IMD-0354
3 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 10MG
- ManufacturerSigma-Aldrich(India)
- Product numberI3159
- Product descriptionIMD-0354 ≥98% (HPLC), solid
- Packaging5MG
- Price₹26835.18
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number401482
- Product descriptionIKK-2 Inhibitor V - CAS 978-62-1 - Calbiochem The IKK-2 Inhibitor V, also referenced under CAS 978-62-1, controls the biological activity of IKK-2. This small molecule/inhibitor is primarily used
- Packaging5MG
- Price₹29850
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberI3159
- Product descriptionIMD-0354 ≥98% (HPLC), solid
- Packaging10MG
- Price₹45486.65
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | I3159 | IMD-0354 ≥98% (HPLC), solid | 5MG | ₹26835.18 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 401482 | IKK-2 Inhibitor V - CAS 978-62-1 - Calbiochem The IKK-2 Inhibitor V, also referenced under CAS 978-62-1, controls the biological activity of IKK-2. This small molecule/inhibitor is primarily used | 5MG | ₹29850 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | I3159 | IMD-0354 ≥98% (HPLC), solid | 10MG | ₹45486.65 | 2022-06-14 | Buy |
Properties
Boiling point :323.1±42.0 °C(Predicted)
Density :1.561
storage temp. :-20°C
solubility :DMSO (5 mg/ml) or Ethanol (1 mg/ml).
form :White solid
pka :7.61±0.43(Predicted)
color :White to off-white
Sensitive :Light Sensitive
CAS DataBase Reference :978-62-1
Density :1.561
storage temp. :-20°C
solubility :DMSO (5 mg/ml) or Ethanol (1 mg/ml).
form :White solid
pka :7.61±0.43(Predicted)
color :White to off-white
Sensitive :Light Sensitive
CAS DataBase Reference :978-62-1
Safety Information
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Description
IMD 0354 is an IKKβ (IKK2) inhibitor that blocks NF-κB phosphorylation (IC50 = ~250 nM) and subsequent NF-κB p65 nuclear translocation. It exhibits cardioprotective properties by decreasing expression of P-selectin and ICAM-1 in the vasculature and blocking cardiomyocyte IL-1β and MCP-1 production, resulting in suppressed neutrophil accumulation in a rat model of ischemia/reperfusion injury. IMD 0354, suppresses the growth of human breast cancer cells by inducing cell cycle arrest and apoptosis. It induces apoptosis of chronic lymphocytic leukemia cells at 1-10 μM by directly targeting the NF-κB pathway, decreasing expression of anti-apoptotic genes and increasing expression of proapoptotic genes.More related product prices
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