TPCA-1
|
- ₹15400 - ₹66876.85
- Product name: TPCA-1
- CAS: 507475-17-4
- MF: C12H10FN3O2S
- MW: 279.29
- EINECS:
- MDL Number:MFCD09037541
- Synonyms:TPCA-1;2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide;5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide;TPCA-1(TPCA 1);3-ThiophenecarboxaMide, 2-[(aMinocarbonyl)aMino]-5-(4-fluorophenyl)-;5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide TPCA-1;TPCA-1 IKK-2 Inhibitor IV;GW683965
3 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 500μG
- 1MG
- 5MG
- ManufacturerSigma-Aldrich(India)
- Product numberT1452
- Product descriptionTPCA-1 ≥95% (HPLC)
- Packaging5MG
- Price₹66876.85
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberT1452
- Product descriptionTPCA-1 ≥95% (HPLC)
- Packaging1MG
- Price₹16746.28
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number401481
- Product descriptionIKK-2 Inhibitor IV - CAS 507475-17-4 - Calbiochem The IKK-2 Inhibitor IV, also referenced under CAS 507475-17-4, controls the biological activity of IKK-2. This small molecule/inhibitor is primarily u
- Packaging500μG
- Price₹15400
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | T1452 | TPCA-1 ≥95% (HPLC) | 5MG | ₹66876.85 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T1452 | TPCA-1 ≥95% (HPLC) | 1MG | ₹16746.28 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 401481 | IKK-2 Inhibitor IV - CAS 507475-17-4 - Calbiochem The IKK-2 Inhibitor IV, also referenced under CAS 507475-17-4, controls the biological activity of IKK-2. This small molecule/inhibitor is primarily u | 500μG | ₹15400 | 2022-06-14 | Buy |
Properties
Melting point :>217°C (dec.)
Boiling point :442.6±45.0 °C(Predicted)
Density :1.490
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL, clear
pka :13.12±0.50(Predicted)
form :powder
color :white to light brown
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Boiling point :442.6±45.0 °C(Predicted)
Density :1.490
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL, clear
pka :13.12±0.50(Predicted)
form :powder
color :white to light brown
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety Information
| Symbol(GHS): |
|
|||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | |||||||||||||||||||||
| Hazard statements: |
|
|||||||||||||||||||||
| Precautionary statements: |
|
Description
TPCA-1 is a selective inhibitor of IκB kinase-2 (IC50s = 17.9 nM and 0.40 μM for IKK2 and IKK1, respectively). Furthermore, it displays greater than 550-fold selectivity over other kinases and enzymes including, p38, MAPK, COX, and JNK. TPCA-1 inhibits the production of LPS-induced TNF-α, IL-6, and IL-8 with IC50 values equal to 0.17, 0.29, and 0.32 μM, respectively. At 20 mg/kg, TPCA-1 has been used to reduce the severity and onset of collagen-induced arthritis in mice and at 30 mg/kg to block cytokine release in an antigen-driven rat model of lung inflammation.Related product price
- MG-132
₹6600.01-40810 - BAY 11-7082
₹9700-15003.45 - TRIS(PENTAFLUOROPHENYL)BORANE
₹8200-471417.93
