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Baicalein

Baicalein Structure
CAS No.
491-67-8
Chemical Name:
Baicalein
Synonyms
5,6,7-trihydroxy-2-phenyl-4H-chroMen-4-one;Baicelein;5,6,7-Trihydroxyflavone,97%;BaicaL;Noroxylin;Baicalein;Baicaleine;Baicalein 98%;Baicalein std.;Baicalein (6CI)
CBNumber:
CB0738154
Molecular Formula:
C15H10O5
Molecular Weight:
270.24
MOL File:
491-67-8.mol
MSDS File:
SDS
Modify Date:
2024/6/7 16:47:56

Baicalein Properties

Melting point 256-271 °C (lit.)
Boiling point 373.35°C (rough estimate)
Density 1.3280 (rough estimate)
refractive index 1.5000 (estimate)
storage temp. Keep in dark place,Sealed in dry,2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
form Yellow solid
pka 6.31±0.40(Predicted)
color Yellow or yellow-green
Merck 14,942
BRN 272683
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
InChIKey FXNFHKRTJBSTCS-UHFFFAOYSA-N
LogP 3.310 (est)
CAS DataBase Reference 491-67-8(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-20/21/22
Safety Statements  26-36
WGK Germany  3
RTECS  DJ3100898
Hazard Note  Irritant
HS Code  29329990
NFPA 704
1
2 0

Baicalein price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 465119 Baicalein 98% 491-67-8 100MG ₹2738.73 2022-06-14 Buy
Sigma-Aldrich(India) 92081 Baicalein analytical standard 491-67-8 50MG ₹12264.73 2022-06-14 Buy
Sigma-Aldrich(India) 465119 Baicalein 98% 491-67-8 500MG ₹9147.13 2022-06-14 Buy
Sigma-Aldrich(India) 196322 Baicalein - CAS 491-67-8 - Calbiochem A cell-permeable flavone that inhibits the activity of 12-lipoxygenase (IC??= 120 nM) and reverse transcriptase. 491-67-8 10MG ₹14260 2022-06-14 Buy
TCI Chemicals (India) T2721 Baicalein 491-67-8 1G ₹8600 2022-05-26 Buy
Product number Packaging Price Buy
465119 100MG ₹2738.73 Buy
92081 50MG ₹12264.73 Buy
465119 500MG ₹9147.13 Buy
196322 10MG ₹14260 Buy
T2721 1G ₹8600 Buy

Baicalein Chemical Properties,Uses,Production

Chemical Properties

Yellow Crystalline Solid

Uses

An inhibitor of 12-lipoxygenase, leukotriene biosynthesis and release of lysosomal enzymes. It also inhibits cellular Ca2+ uptake and mobilization and adjuvant-induced arthritis. Baicalein is the fl avonoid component of Nepalese and Sino-Japanese crude drugs.

Definition

ChEBI: A trihydroxyflavone with the hydroxy groups at positions C-5, -6 and -7.

General Description

Baicalein, a flavonoid, is a xanthine oxidase inhibitor. Anti-inflammatory effects of baicalein in peripheral human leukocytes has been studied.

Biological Activity

Inhibitor of 5- and platelet 12-lipoxygenases (IC 50 values are 9.5 and 0.12 mM respectively). Also inhibits Raf-mediated MEK-1 phosphorylation in C6 rat glioma cells and induces G1 and G2 cell cycle arrest by decreasing cdk1, cdk2, cyclin D2 and cyclin A expression. Anti-inflammatory in vivo .

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Baicalein Spectrum

BAICALEIN(SH)NOW RG GRADE Baicalein, monohydrate, 5,6,7-Trihydroxy-2-phenyl-4H-chromen-4-one monohydrate Noroxylin Baicalein 98% 5,6,7-trihydroxy-2-phenyl-4-chromenone hydrate Baicaleine Baicalein 5,6,7-trihydroxy-2-phenyl-chromen-4-one hydrate 5,6,7-trihydroxy-2-phenylchromen-4-one hydrate 5,6,7-trihydroxy-2-phenyl-chromone hydrate Bupleurum distillates 4H-1-BENZOPYRAN-4-ONE,5,6,7-TRIHYDROXY-2-PHENYL- 5,6,7-TRIHYDROXY-2-PHENYL-(4H)-1-BENZOPYRAN-4-ONE 5,6,7-TRIHYDROXYFLAVONE BAICALEIN, 98+% BY HPLC BAICALEIN4H-1-BENZOPYRAN-4-ONE,5,6,7-TRIHYDROXY-2-PHENYL-, Baicalein std. Nano Liposomal Baicalein Baicalein, 98%, from Scutellaria baicalensis Georgi BaicaL Baicalein - CAS 491-67-8 - Calbiochem Baicalein 491-67-8 5,6,7-trihydroxy-2-phenyl-1-benzopyran-4-one hydrate Baicalein NanoEmulsion, Water-Soluble Baicalein, Liposomal Baicalein Baicalein Standard Baicalein USP/EP/BP Baicalein (10mM in DMSO) Baicalein / Noroxylin Scutellaria Baicalensis Extract Baicalein 98% 5,6,7-trihydroxy-2-phenylchromen-4-one Baicelein 5,6,7-trihydroxy-2-phenyl-4H-chroMen-4-one 5,6,7-Trihydroxyflavone,97% Baicalein (6CI) 491-67-8 C15H10O5H2O C15H10O5xH2O The flavonoid component of Nepalese and Sino-Japanese crude drugs Enzyme Inhibitors Enzyme Inhibitors by Type Enzymes, Inhibitors, and Substrates Phytoestrogens Other Biochemicals and Reagents BioChemical Chemopreventive Agents Cancer Research API Aromatics Heterocycles chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract natural product Tri-substituted Flavones Inhibitors