Curcumin
- CAS No.
- 458-37-7
- Chemical Name:
- Curcumin
- Synonyms
- TURMERIC EXTRACT;halad;haldar;curcuma;Diferuloylmethane;Curcumin, Natural Yellow 3, Diferuloylmethane;yo-kin;souchet;kurkumin;Crucumin
- CBNumber:
- CB4183426
- Molecular Formula:
- C21H20O6
- Molecular Weight:
- 368.38
- MOL File:
- 458-37-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/24 13:33:21
| Melting point | 183 °C |
|---|---|
| Boiling point | 418.73°C (rough estimate) |
| Density | 0.93 |
| vapor density | 13 (vs air) |
| refractive index | 1.4155-1.4175 |
| Flash point | 208.9±23.6 °C |
| storage temp. | 2-8°C |
| solubility | ethanol: 10 mg/mL |
| form | powder |
| pka | 8.09(at 25℃) |
| Colour Index | 75300 |
| color | orange |
| Odor | Odorless |
| PH Range | Yellow (7.8) to red-brown (9.2) |
| Water Solubility | Slightly soluble (hot) |
| λmax | 430nm |
| Merck | 14,2673 |
| Solvent | Ethanol |
| Concentration | 1 mCi/ml |
| Specific Activity | 5-15 Ci/mmol |
| BRN | 2306965 |
| Stability | Stable, but may be light sensitive. Incompatible with strong oxidizing agents. |
| Major Application | Cosmetics, drug-eluting stents, inhibition of formation of skin-wrinkles, treating alzheimer’s disease, skin diseases, coronary restenosis, diabetes, obesity, leukemia, neurofibromas, cancer, antimicrobial, antiviral, antiinflammatory, antiprostate cancer |
| InChIKey | VFLDPWHFBUODDF-FCXRPNKRSA-N |
| LogP | 3.290 (est) |
| CAS DataBase Reference | 458-37-7(CAS DataBase Reference) |
| EPA Substance Registry System | Curcumin (458-37-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319 | |||||||||
| Precautionary statements | P210-P233-P240-P241-P242-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | MI5230000 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29145000 | |||||||||
| Toxicity | LD50 Oral-Rat-12.200 mg/kg | |||||||||
| NFPA 704 |
|
Curcumin price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C1386 | Curcumin from Curcuma longa (Turmeric), powder | 458-37-7 | 5G | ₹2564.1 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR2209 | Curcumin Pharmaceutical Secondary Standard; Certified Reference Material | 458-37-7 | 50MG | ₹14851.8 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C7727 | Curcumin ≥94% (curcuminoid content), ≥80% (Curcumin) | 458-37-7 | 500MG | ₹18548.1 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C1386 | Curcumin from Curcuma longa (Turmeric), powder | 458-37-7 | 10G | ₹4406.7 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C1386 | Curcumin from Curcuma longa (Turmeric), powder | 458-37-7 | 50G | ₹14718.6 | 2022-06-14 | Buy |
Curcumin Chemical Properties,Uses,Production
Description
The main source of curcumin is the root of Zingiberaceae Curcuma aromatica, rhizome of Curcuma longa (Jiang Huang), Curcuma zedoaria, and Acorus calamus. Among them, Jiang Huang contains about 3–6% curcumin. The traditional Chinese medicine, Jiang Huang, is the root tuber of perennial herbaceous plant Curcuma longa L. of family Zingiberaceae. It was firstly recorded in the “Tang materia medica” (Xin Xiu Ben Cao). It is pungent, bitter, and warm and enters the liver and spleen meridians. It activates the blood, moves qi, dredges meridians, and alleviates pain. In India and other Asian countries, Jiang Huang has more than 6000?years of application history. In Japan, Jiang Huang has a long history of health care, and the people of Okinawa Island regarded Jiang Huang as a holy tribute to the emperor. Jiang Huang mainly comes from Taiwan, Fujian, Guangdong, Guangxi, Yunnan, and Tibet of China and other regions in East Asia and Southeast Asia. It grows in warm and humid climate and sunny environment with abundant rainfall and fears cold frost, drought, and flood. At present, Chinese Pharmacopoeia only included Jiang Huang and Yu Jin which contains curcumin, while curcumin is not included.
Chemical Properties
orange crystalline powder
Physical properties
Appearance: orange-brown crystalline powder and tastes a little bitter. It will turn into reddish brown in alkaline solution and yellow in neutral and acidic solution. It has strong stability against the reducing agent. It has excellent pigmentation which is not easy to fade. It is sensitive to light, heat, and iron ion. When PH is greater than
8, curcumin turns from yellow to red, which can be used as a pH indicator.
Solubility: insoluble in water or diethyl ether and soluble in ethanol, propylene
glycol, acetic acid, and alkali solution.
Melting point: about 183 °C.
Uses
Curcumin is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). The curcuminoids are polyphenols and are responsible for the yellow color of turmeric. Curcumin can exist in at least two t
Definition
ChEBI: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
General Description
Orange-yellow needles.
Air & Water Reactions
Slightly soluble in hot water .
Reactivity Profile
Curcumin is sensitive to light and changes in pH. Curcumin may react with oxidizing materials.
Biological Activity
Antitumor, anti-inflammatory and antioxidant agent. Downregulates expression of reactive-oxygen-generating enzymes (cyclooxygenase, lipoxygenase, iNOS), TNF α , IL-1, IL-6, PKC, EGFR, NF- κ B, I κ B kinase and more. Upregulates expression of PPAR γ , p53, Nrf2. Also displays antimicrobial, antidiabetic neuro- and cardioprotective properties in vivo .
Mechanism of action
Curcumin, the active component of turmeric (Curcuma longa), has been regarded as an anti-inflammatory and antioxidant agent . Particularly, it can scavenge reactive oxygen species, such as hydroxyl radicals, superoxide anion radicals, and nitrogen dioxide radicals. Additionally, it serves as an anti-inflammatory by down-regulating the production of pro-inflammatory cytokines (e.g., IL-1 and TNF-α) and inhibiting the activation of specific transcription factors (e.g., NF-κB and AP-1). Curcumin also demonstrates antiproliferative properties. Specifically, it inhibits UV radiation-induced skin cancer in SKH-1 hairless mice and reduces UVB-induced matrix metalloproteinase-1/3 expression in human dermal fibroblasts via MAPK-p38/JNK pathway suppression.
Clinical Use
1. Cholagogic effect could promote bile formation and secretion.
2. Hypolipidemic effect could reduce the level of cholesterol in the blood and prevent atherosclerosis.
3. Antibacterial and antiviral effect could inhibit Staphylococcus aureus and HIV.
4. Liver protection.
5. Anticancer and antitumor effect.
6. Help with the prevention of dementia.
7. Anti-inflammation and treatment of acne and dermatitis.
8. There are no reports of adverse effect of curcumin till now.
Purification Methods
Crystallise curcumin from EtOH or acetic acid. [Beilstein 8 IV 3697.]
Curcumin Preparation Products And Raw materials
Raw materials
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| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 32 | 58 | Inquiry |
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| BIOCHEMICAL & SYNTHETIC PRODUCTS PVT. LT., | +91-91-8421973722 +91-9869455944 | Telangana, India | 31 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| Audi Pharma Ingredients | +91-9841058280 +91-9841058280 | Tamil Nadu, India | 7 | 58 | Inquiry |
| CHEMAZON LABORATORIES | +91 9848551964 | Hyderabad, India | 1320 | 58 | Inquiry |
| Standardcon Pvt. Ltd | +91-9323087138 +91-9323087138 | Maharashtra, India | 31 | 58 | Inquiry |
| Sun Food Tech | +91-9717799051 +91-9268579051 | New Delhi, India | 21 | 58 | Inquiry |
| AOS Products Pvt Ltd | +91-8285111618 +91-8285111618 | Uttar Pradesh, India | 76 | 58 | Inquiry |
| BioMax | +91-9987557585 +91-9987557585 | Maharashtra, India | 4 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Otto Chemie Pvt. Ltd. | 58 |
| GLR Innovations | 58 |
| BIOCHEMICAL & SYNTHETIC PRODUCTS PVT. LT., | 58 |
| JSK Chemicals | 58 |
| Audi Pharma Ingredients | 58 |
| CHEMAZON LABORATORIES | 58 |
| Standardcon Pvt. Ltd | 58 |
| Sun Food Tech | 58 |
| AOS Products Pvt Ltd | 58 |
| BioMax | 58 |
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