Methscopolamine bromide
- CAS No.
- 155-41-9
- Chemical Name:
- Methscopolamine bromide
- Synonyms
- nutrop;pamine;blocan;diopal;ampyrox;holopan;holopon;paraspan;-tropate;mescopil
- CBNumber:
- CB0746986
- Molecular Formula:
- C18H24BrNO4
- Molecular Weight:
- 398.29
- MOL File:
- 155-41-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/1/9 16:19:47
| Melting point | 214-217 °C (decomp) |
|---|---|
| refractive index | -24 ° (C=1, H2O) |
| storage temp. | Store at -20°C |
| solubility | H2O: 50 mg/mL |
| form | powder |
| color | white |
| optical activity | [α]25/D 25°, c = 5 in H2O(lit.) |
| Merck | 14,6003 |
| Stability | Hygroscopic |
| CAS DataBase Reference | 155-41-9 |
| EPA Substance Registry System | 3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane, 7-[(2S)-3-hydroxy-1-oxo-2-phenylpropoxy]-9,9-dimethyl-, bromide (1:1), (1.alpha.,2.beta.,4.beta.,5.alpha.,7.beta.)- (155-41-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H312+H332-H400 | |||||||||
| Precautionary statements | P261-P271-P273-P280-P302+P352+P312-P304+P340+P312 | |||||||||
| Hazard Codes | T,N,Xn | |||||||||
| Risk Statements | 23/24/25-50/53-20/21/22-20/21 | |||||||||
| Safety Statements | 36/37/39-45-61-60-36/37 | |||||||||
| RIDADR | UN 1544 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | YM3675000 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29399990 | |||||||||
| NFPA 704 |
|
Methscopolamine bromide price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | S8502 | (−)-Scopolamine methyl bromide ≥98% (HPLC), powder | 155-41-9 | 1G | ₹7296.05 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | S8502 | (−)-Scopolamine methyl bromide ≥98% (HPLC), powder | 155-41-9 | 5G | ₹24735.13 | 2022-06-14 | Buy |
| TCI Chemicals (India) | S0231 | Scopolamine Methyl Bromide | 155-41-9 | 1G | ₹7200 | 2022-05-26 | Buy |
Methscopolamine bromide Chemical Properties,Uses,Production
Chemical Properties
Methscopolamine Bromide is an anticholinergic, which occurs as white crystals, or as a white odorless crystalline powder. It melts at about 225°C with decomposition. The drug is freely soluble in water, slightly soluble in alcohol, and insoluble in acetone and in chloroform.
Uses
Methscopolamine bromide is the methylated derivative of Scopolamine, a muscarinic antagonist that is similar to acetylcholine. It have been used for the treatment of peptic ulcers by reducing acid secretion of the stomach and is used to treat morning sickness.
Definition
ChEBI: Scopolamine methyl bromide is a quaternary ammonium salt resulting from the reaction of the amino group of scopolamine with methyl bromide. It has a role as a muscarinic antagonist, an antiemetic, an antispasmodic drug and a parasympatholytic. It is a quaternary ammonium salt and a bromide salt. It is functionally related to a scopolamine.
Mode of action
methscopolamine bromide is used to treat gastrointestinal disorders such as peptic ulcers, irritable bowel syndrome, and stomach cramps. Its mechanism of action involves blocking the action of acetylcholine on smooth muscle cells in the digestive tract, thereby reducing spasms and increasing motility.
References
[1] ANDRé ROBERT JAMES E N. Effect of an anti-acetylcholine drug, methscopolamine bromide, on ulcer formation and gastric mucus[J]. Journal of Pharmacy and Pharmacology, 1964, 16 10: 690-695. DOI:10.1111/j.2042-7158.1964.tb07388.x.
[2] M A WASSERMAN R L G. Bronchospasmolytic effects of methscopolamine bromide.[J]. Journal of Pharmacology and Experimental Therapeutics, 1979, 211 1: 159-166.
[3] J A DANIEL. Methscopolamine bromide blocks hypothalamic-stimulated release of growth hormone in ewes.[J]. Journal of animal science, 1997, 75 5: 1359-1362. DOI:10.2527/1997.7551359x.
Methscopolamine bromide Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Alkaloids Private Limited | +91-9866110664 +91-9866110664 | Telangana, India | 25 | 58 | Inquiry |
| Prism Industries Ltd | +91-9825050731 +91-9227406992 | Gujarat, India | 28 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| Grr Fine Chem/Grr Exports | 91-79-40031771 | Gujarat, India | 405 | 58 | Inquiry |
| Alain Pharmaceuticals | 08069013892Ext 353 | Hyderabad, India | 44 | 58 | Inquiry |
| ALCHEM INTERNATIONAL PRIVATE LIMITED | +91-11-26809882 | New Delhi, India | 15 | 58 | Inquiry |
| Vyshno Bio Sciences | 91-7095439993 | Hyderabad, India | 239 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Alkaloids Private Limited | 58 |
| Prism Industries Ltd | 58 |
| Pharma Affiliates | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| SynZeal Research Pvt Ltd | 58 |
| Clearsynth Labs | 58 |
| Grr Fine Chem/Grr Exports | 58 |
| Alain Pharmaceuticals | 58 |
| ALCHEM INTERNATIONAL PRIVATE LIMITED | 58 |
| Vyshno Bio Sciences | 58 |
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