GUANFACINE HCL
- CAS No.
- 29110-48-3
- Chemical Name:
- GUANFACINE HCL
- Synonyms
- GUANFACINE HYDROCHLORIDE;Tenex;Intuniv;lon798;estulic;bs100-141;Guarfacine;Guanfascine;GUANFACINE HCL;Guanfacine HCL powder
- CBNumber:
- CB0767424
- Molecular Formula:
- C9H10Cl3N3O
- Molecular Weight:
- 282.55
- MOL File:
- 29110-48-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/26 15:15:06
| Melting point | 215-217℃ |
|---|---|
| RTECS | CY1481000 |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | H2O: 12 mg/mL at 60 °C, soluble |
| form | Solid |
| color | white |
| Merck | 14,4561 |
| Stability | Hygroscopic |
| InChIKey | DGFYECXYGUIODH-UHFFFAOYSA-N |
| CAS DataBase Reference | 29110-48-3(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P264-P270-P301+P310a-P321-P405-P501a | |||||||||
| RIDADR | 3249 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2925294500 | |||||||||
| Toxicity | LD50 in mice: 165 mg/kg orally (Coward) | |||||||||
| NFPA 704 |
|
GUANFACINE HCL price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | G1043 | Guanfacine hydrochloride ≥98% (HPLC) | 29110-48-3 | 10MG | ₹6300.15 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1751 | Guanfacine hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material | 29110-48-3 | 500MG | ₹15198.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | G1043 | Guanfacine hydrochloride ≥98% (HPLC) | 29110-48-3 | 50MG | ₹28134.18 | 2022-06-14 | Buy |
| TCI Chemicals (India) | G0414 | Guanfacine Hydrochloride | 29110-48-3 | 100MG | ₹9800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | G0414 | Guanfacine Hydrochloride | 29110-48-3 | 1G | ₹29400 | 2022-05-26 | Buy |
GUANFACINE HCL Chemical Properties,Uses,Production
Uses
Centrally acting a-adrenoceptor agonist. Antihypertensive
General Description
Guanfacine hydrochloride,N-(aminoiminomethyl)-2,6-dichlorobenzeneacetamide(Tenex), is structurally related to clonidine hydrochloride andguanabenz acetate and shares many of their pharmacologicalproperties. The drug has a longer duration of action than eitherclonidine hydrochloride or guanabenz acetate. It lasts upto 24 hours. It also requires much longer (8–12 hours) for apeak effect to occur after the drug is administered.
Biological Activity
Selective α 2A -adrenoceptor agonist (K d = 31 nM). Displays 60-fold selectivity over α 2B -adrenoceptors. Also available as part of the α 2 -Adrenoceptor Tocriset™ .
Pharmacokinetics
The pharmacokinetic properties for guanfacine differ from those of clonidine, guanabenz, and α-methyldopa. At pH 7.4,
guanfacine is predominately (67%) in the nonionized, lipid-soluble base form, which accounts for its high oral
bioavailability (>80%). Following an oral dose, peak plasma concentrations occur in 1 to 4 hours, with a relatively long
elimination half-life of 14 to 23 hours. The maximum blood pressure response occurs in 8 to 12 hours after oral
administration and is maintained up to 36 hours following its discontinuation. Following IV dosing, guanfacine achieves
the highest concentrations in liver and kidney, with low concentrations in the brain. Guanfacine is 64% bound to
plasma proteins. In patients with hepatic or renal impairment, its elimination half-life may be prolonged.
Guanfacine is metabolized principally by hepatic hydroxylation to its inactive metabolite, 3-hydroxyguanfacine (20%),
which is eliminated in the urine as its glucuronide (30%), sulfate (8%), or mercapturic acid conjugate (10%), and 24 to
37% is excreted as unchanged guanfacine. Its nearly complete bioavailability suggests no evidence of any
first-pass effect. Guanfacine and its inactive metabolites are excreted principally in urine, with approximately 80% of its
oral dose excreted in urine within 48 hours.
Clinical Use
Overall, the therapeutic applications for guanfacine are similar to those of the other centrally acting α2-adrenergic agonists and methyldopa. It has been effective as monotherapy in the treatment of patients with mild to moderate hypertension. One advantage for guanfacine is its once-a-day dosing schedule. The use of diuretics to prevent accumulation of fluid may allow a reduction in the dosage for guanfacine.
Side effects
Overall, although the frequency of troublesome adverse effects produced by guanfacine is similar to that produced by clonidine and the other centrally acting sympatholytics, their incidence and severity are lower with guanfacine. Unlike clonidine, abrupt discontinuation of guanfacine rarely results in rebound hypertension. When a withdrawal syndrome has occurred, its onset was slower and its symptoms less severe than the syndrome observed with clonidine.
GUANFACINE HCL Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Triveni Interchem Private Limited (Group Of Triveni... | 08046042087 | Gujarat, India | 497 | 58 | Inquiry |
| Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 | China | 5959 | 58 | Inquiry |
| Hebei Guanlang Biotechnology Co,.LTD | +86-19930503253; +8619930503252 | China | 5835 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29898 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
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