Carvedilol
- CAS No.
- 72956-09-3
- Chemical Name:
- Carvedilol
- Synonyms
- 1-((9H-Carbazol-4-yl)oxy)-3-((2-(2-Methoxyphenoxy)ethyl)aMino)propan-2-ol;COREG;Artist;1-(9h-carbazol-4-yloxy)-3-((2-(2-methoxyphenoxy)ethyl)amino)-2-propano;Carca;Kredex;Querto;Carloc;Carvas;DQ-2466
- CBNumber:
- CB8351959
- Molecular Formula:
- C24H26N2O4
- Molecular Weight:
- 406.47
- MOL File:
- 72956-09-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/7/3 17:51:04
| Melting point | 113-117°C |
|---|---|
| Boiling point | 655.2±55.0 °C(Predicted) |
| Density | 1.250±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: >20mg/mL |
| pka | 13.90±0.20(Predicted) |
| form | solid |
| color | white to off-white |
| Water Solubility | 449.2ug/L(22.5 ºC) |
| Merck | 14,1873 |
| CAS DataBase Reference | 72956-09-3(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS09 |
|---|---|
| Signal word | Warning |
| Hazard statements | H411 |
| Precautionary statements | P273-P391-P501 |
| Hazard Codes | N,Xn |
| Risk Statements | 51/53-36/37/38-20/21/22 |
| Safety Statements | 61-36-26 |
| RIDADR | UN 3077 9/PG 3 |
| WGK Germany | 3 |
| RTECS | UA8670000 |
| HazardClass | IRRITANT |
| PackingGroup | III |
| HS Code | 2933995300 |
| Toxicity | LD50 oral in dog: > 1gm/kg |
Carvedilol price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR1265 | Carvedilol Pharmaceutical Secondary Standard; Certified Reference Material | 72956-09-3 | 1G | ₹9093 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C3993 | Carvedilol ≥98% (HPLC), solid | 72956-09-3 | 50MG | ₹10240.45 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C3993 | Carvedilol ≥98% (HPLC), solid | 72956-09-3 | 250MG | ₹43668.05 | 2022-06-14 | Buy |
Carvedilol Chemical Properties,Uses,Production
Description
Carvedilol is a vasodilating beta-blocker useful in the treatment of hypertension and angina pectoris. In addition to lowering blood pressure, carvedilol decreases total vascular resistance without the reflex tachycardia usually occurring with vasodilators. It is reported to be well tolerated with renal sparing effects.
Chemical Properties
Colourless Crystalline Solid
Uses
Carvedilol is a nonselective β-adrenergic blocker with α1-blocking activity. Carvedilol is an antihypertensive used in the treatment of congestive heart failure.
Definition
ChEBI: A member of the class of carbazoles that is an adrenergic antagonist with non-selective beta- and alpha-1 receptor blocking properties which helps in the management of congestive heart failure.
General Description
Carvedilol (Coreg) is a β-blocker that hasa unique pharmacological profile. Like labetalol, it is aβ-blocker that possesses α1-blocking activity. Only the(S) enantiomer possesses the β-blocking activity, althoughboth enantiomers are blockers of the α1-receptor. Overall,its β-blocking activity is 10- to 100-fold of its α-blocking activity.
Biological Activity
Potent β -adrenoceptor and α 1 -adrenoceptor antagonist (K i values are 0.81, 0.96 and 2.2 nM for β 1 -, β 2 - and α 1 -adrenoceptors respectively) that displays antihypertensive and peripheral vasodilatory activity. Blocks cardiac inward-rectifier K + (K IR ) channels, voltage-dependent Ca 2+ channels and exhibits antioxidant properties at higher concentrations.
Clinical Use
Carvedilol is also unique in that it possesses antioxidantactivity and an antiproliferative effect on vascular smoothmuscle cells. It thus has a neuroprotective effect and the abilityto provide major cardiovascular organ protection. It isused in treating hypertension and congestive heart failure.
Carvedilol Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Jigs Chemical ltd | +919099003427 | Gujarat, India | 239 | 58 | Inquiry |
| Cadila Pharmaceuticals Ltd | +91-7069076657 +91-7069076657 | Ahmedabad, India | 54 | 58 | Inquiry |
| Chemicea Pharmaceuticals Pvt Ltd | +91-918482849343 +91-8482849343 | Mumbai, India | 461 | 58 | Inquiry |
| S.V ENTERPRISES | +919322701159 | Mumbai, India | 150 | 58 | Inquiry |
| SNECOFRi Pvt Ltd | +91-9032850129 +91-9032850129 | Telangana, India | 404 | 58 | Inquiry |
| GLP Pharma Standards | +91 9866074638 | Hyderabad, India | 1644 | 58 | Inquiry |
| Gonane Pharma | +91-9819380043 +91-9819380043 | NaviMumbai, India | 192 | 58 | Inquiry |
| Aurobindo Pharma Limited | +914066725000 | Telangana, India | 112 | 58 | Inquiry |
| Viyash Life Sciences Pvt Ltd | +91-4023635052 +91-4023635052 | Telangana, India | 213 | 58 | Inquiry |
| Cipla Ltd | +912224826000 | Maharashtra, India | 133 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Jigs Chemical ltd | 58 |
| Cadila Pharmaceuticals Ltd | 58 |
| Chemicea Pharmaceuticals Pvt Ltd | 58 |
| S.V ENTERPRISES | 58 |
| SNECOFRi Pvt Ltd | 58 |
| GLP Pharma Standards | 58 |
| Gonane Pharma | 58 |
| Aurobindo Pharma Limited | 58 |
| Viyash Life Sciences Pvt Ltd | 58 |
| Cipla Ltd | 58 |
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