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ChemicalBook > Product Catalogue >API >Circulatory system drugs >Peripheral vasodilators >Carvedilol

Carvedilol

Carvedilol Structure
  • ₹9093 - ₹43668.05
  • Product name: Carvedilol
  • CAS: 72956-09-3
  • MF: C24H26N2O4
  • MW: 406.47
  • EINECS:1308068-626-2
  • MDL Number:MFCD00864692
  • Synonyms:1-(9H-CARBAZOL-4-YLOXY)-3-[[2-(2-METHOXYPHENOXY)ETHYL]AMINO]-2-PROPANOL;CARVEDILOL;DIMITONE;DQ-2466;DILATREND;BM-14190;1-(9h-carbozol-4-yloxy)-3-[[2-(2-methoxy phenoxy)ethyl] amino]-2-propanol;1(9H-CARBAZOL-4-YLOXY)-3-[[(2-(2-METHOXYPHENOXY)ETHYL]AMINO]-2-PROPANOL (CARVEDILOL)
Price3 Properties Safety Information Description
3 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 50MG
  • 250MG
  • 1G
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR1265
  • Product descriptionCarvedilol Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging1G
  • Price₹9093
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC3993
  • Product descriptionCarvedilol ≥98% (HPLC), solid
  • Packaging50MG
  • Price₹10240.45
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC3993
  • Product descriptionCarvedilol ≥98% (HPLC), solid
  • Packaging250MG
  • Price₹43668.05
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) PHR1265 Carvedilol Pharmaceutical Secondary Standard; Certified Reference Material 1G ₹9093 2022-06-14 Buy
Sigma-Aldrich(India) C3993 Carvedilol ≥98% (HPLC), solid 50MG ₹10240.45 2022-06-14 Buy
Sigma-Aldrich(India) C3993 Carvedilol ≥98% (HPLC), solid 250MG ₹43668.05 2022-06-14 Buy

Properties

Melting point :113-117°C
Boiling point :655.2±55.0 °C(Predicted)
Density :1.250±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >20mg/mL
pka :13.90±0.20(Predicted)
form :solid
color :white to off-white
Water Solubility :449.2ug/L(22.5 ºC)
Merck :14,1873
CAS DataBase Reference :72956-09-3(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H411 Toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 2
Precautionary statements:
P273 Avoid release to the environment.
P391 Collect spillage. Hazardous to the aquatic environment
P501 Dispose of contents/container to..…

Description

Carvedilol is a non-selective β-antagonist with α1-adrenolytic activity that binds the α1-, α2-, and β1-adrenoceptors with Ki values of 2.2 nM, 3.4 μM, and 0.81 nM, respectively. By inhibiting excess stimulation of catecholamine it demonstrates antiarrhythmic activity in a rat model of adrenaline-induced arrhythmia with an ED50 value of 0.25 mg/kg. Carvedilol has also been shown to activate cardioprotective signaling through β-arrestin and ERK1/2 activation (EC50 = 2 nM).

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Jigs Chemical ltd Cadila Pharmaceuticals Ltd Chemicea Pharmaceuticals Pvt Ltd S.V ENTERPRISES SNECOFRi Pvt Ltd Gonane Pharma Murli Krishna Exports Pvt Ltd Aurobindo Pharma Limited Viyash Life Sciences Pvt Ltd Cipla Ltd