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Selamectin

Selamectin Structure
CAS No.
220119-17-5
Chemical Name:
Selamectin
Synonyms
Skudin;Siratine;Silamycin;Stronghold;Selamectin;Selamection;Seragliptin;Selamectin（b）;Selamectin CRS;hypnocarpic acid
CBNumber:
CB0947411
Molecular Formula:
C43H63NO11
Molecular Weight:
769.97
MOL File:
220119-17-5.mol
Modify Date:
2024/9/29 20:12:18
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Selamectin Properties

Melting point >180°C
Boiling point 917.0±65.0 °C(Predicted)
Density 1.35±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Dichloromethane (Slightly, Heated), DMSO (Slightly)
form Solid
pka 10.34±0.70(Predicted)
color White to Yellow
Stability Hygroscopic
InChI InChI=1/C43H63NO11/c1-24-11-10-14-30-23-50-40-36(44-48)27(4)19-33(43(30,40)47)41(46)52-32-20-31(16-15-25(2)38(24)53-35-21-34(49-6)37(45)28(5)51-35)54-42(22-32)18-17-26(3)39(55-42)29-12-8-7-9-13-29/h10-11,14-15,19,24,26,28-29,31-35,37-40,45,47-48H,7-9,12-13,16-18,20-23H2,1-6H3/b11-10+,25-15+,30-14+,44-36-/t24-,26-,28-,31+,32-,33-,34-,35-,37-,38-,39-,40+,42+,43+/s3
InChIKey AFJYYKSVHJGXSN-KAJWKRCWSA-N
SMILES O[C@]12C3=CC=C[C@@H]([C@@H](C(C)=CC[C@@]4([H])O[C@@]5(CC[C@H](C)[C@@H](C6CCCCC6)O5)C[C@]([H])(C4)OC(=O)[C@]1([H])C=C(C)/C(=N/O)/[C@@]2([H])OC3)O[C@]1([H])O[C@@H](C)[C@H](O)[C@@H](OC)C1)C |t:2,4,9,&1:1,6,7,12,15,18,20,29,35,43,48,51,53,55,r|
CAS DataBase Reference 220119-17-5

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H413
Precautionary statements  P273-P501
WGK Germany  3
HS Code  2932206000

Selamectin price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 32476 Selamectin VETRANAL?, analytical standard 220119-17-5 10MG ₹43105.15 2022-06-14 Buy
Product number Packaging Price Buy
32476 10MG ₹43105.15 Buy

Selamectin Chemical Properties,Uses,Production

Description

Selamectin is formulated as a spot-on for cats and dogs to control fleas (Ctenocephalides spp.) and flea-allergy dermatitis, to prevent heartworm disease, and to control ear mites (Otodectes cynotes) in cats and dogs. It is also approved for the treatment and control of sarcoptic mange (Sarcoptes scabiei) in dogs and hookworms (Ancylostoma tubaeformis) and roundworms (Toxocara cati) in cats.

Uses

Selamectin is a topical parasiticide and also used as a veterinary antihelminithic agent on animals.

Hazard

Selamectin is a veterinary drug for the prevention or treatment of internal and external parasites in cats and dogs and is not approved for use in humans. It is a very safe drug, but overdose or accidental exposure may result in poisoning. In rare cases, humans may experience skin reactions such as hives, itching and redness of the skin.

Mechanism of action

Selamectin is a semi-synthetic avermectin that belongs to the class of macrolides. These drugs are neurotoxic to the parasite by enhancing glutamate-gated chloride ion channels in the parasite. The parasite becomes paralysed and dies due to increased permeability of chloride ions and hyperpolarisation of nerve cells. These drugs also potentiate other chloride channels, including those gated by gamma-aminobutyric acid (GABA). Mammals are usually unaffected because they lack glutamate-gated chloride channels and have a lower affinity for other mammalian chloride channels. Since these drugs do not normally penetrate the blood-brain barrier, GABA-gated channels in the mammalian CNS are not affected. Following topical administration, Selamectin has a high affinity for sebaceous glands and skin.

Toxicity evaluation

Acute oral LD50 for rats: >1,600 mg/kg

Selamectin Preparation Products And Raw materials

Raw materials

Preparation Products

Selamectin Suppliers

Global( 235)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
ENBRIDGE PHARMTECH CO., LTD. +8613812269233 China 302 58 Inquiry
AFINE CHEMICALS LIMITED +86-0571-85134551 China 15373 58 Inquiry
S&Y Biochem Co.,Ltd +8617774091612 China 119 58 Inquiry
Wuhan Fortuna Chemical Co., Ltd +86-027-59207850 China 5987 58 Inquiry
Henan Fengda Chemical Co., Ltd +86-371-86557731 +86-13613820652 China 20290 58 Inquiry
Sigma Audley +86-15937194204 +86-18126314766 China 491 58 Inquiry
Supplier Advantage
SynZeal Research Pvt Ltd 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
ENBRIDGE PHARMTECH CO., LTD. 58
AFINE CHEMICALS LIMITED 58
S&Y Biochem Co.,Ltd 58
Wuhan Fortuna Chemical Co., Ltd 58
Henan Fengda Chemical Co., Ltd 58
Sigma Audley 58

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Selamectin AverMectin A1a,25-cyclohexyl-4'-O-de(2,6-dideoxy-3-O-Methyl-a-L-arabino-hexopyranosyl)-5-deMethoxy-25-de(1-Methylpropyl)-22,23-dihydro-5-(hydroxyiMino)-,(5Z)- hypnocarpic acid (5Z)-25-Cyclohexyl-4'-O-de(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)-avermectin A1a Revolution (antibiotic) Stronghold Selamectin CRS Avermectin A1a, 25-cyclohexyl-4'-O-de(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)-, (5Z)- Oxaliplatin Impurity5（EP Impurity D） selamectin ceutical Avermectin A1a, 25-cyclohexyl-4-O-de(2,6-dideoxy-3-O-methyl-... Selamection Selamectin (1611729) Sierra rhzomorph Skudin (2R,2a'E,2a1'S,4'E,5S,6S,6'S,7'S,8'E,11'R,15'S,17a'R,20'Z,20a'R)-6-Cyclohexyl-2a1'-hydroxy-7'-(((2R,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-20'-(hydroxyimino)-5,6',8',19'-tetramethyl-2a1',3,4,5,6,6',7',10',11',14',15',17a',20',20a'-tetradecahydro-2'H,17'H-spiro[pyran-2,13'-[11,15]methano[1,5]dioxacyclooctadecino[9,8,7-cd]benzofuran]-17'-one Selamectin（b） (2R,2a'E,2a1'S,4'E,5S,6S,6'S,7'S,8'E,11'R,15'S,17a'R,20'Z,20a'R)-6-Cyclohexyl-2a1'-hydroxy-7'-(((2R,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-20'-(hydroxyimino)-5,6',8',19'-tetramethyl-2a1',3,4,5,6,6',7',10',11',14',15',17a',20',20a'-tetradecahydro-2'H,17'H-spiro[pyran-2,13'-[11,15]methano[1,5]dioxacyclooctadecino[9,8,7-cd]benzofuran]-17'-one Seragliptin Silamycin Siratine 220119-17-5 C43H63NO11 Anthelmintic ectoparasiticide API 220119-17-5