2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one

CAS No.: 142217-81-0

Chemical Name:: 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one

Synonyms: DIBENZYLOXY GUANINE INTERMEDIATE;2-aMino-1,9-dihydro-9-[(1S,3R,4S)-2-Methylene-4-(benzyloxy)-3-[(benzyloxy)Methyl]cyclopentyl]-6H-Purin-6-one;ETA/ET1/N8;Entecavir-9;Entecavir E8;N-1 Entecavir API;Dibenzyl Entecavir;US-DMF No.: 026257;Entecavir Impurity 4;Entecavir dibenzylated

CBNumber:: CB11562443

Molecular Formula:: C26H27N5O3

Molecular Weight:: 457.52

MOL File:: 142217-81-0.mol

Modify Date:: 2024/4/26 17:21:34

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2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one Properties

Melting point	245-247°C (dec.)
Density	1.34
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	DMSO (Slightly)
form	Solid
pka	9?+-.0.20(Predicted)
color	White to Pale Beige
CAS DataBase Reference	142217-81-0(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

HS Code	29335990

2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one Chemical Properties,Uses,Production

Chemical Properties

White powder

Uses

3’5’Di-O-benzyl Entecavir is an intermediate in the preparation of the hepatitis B antiviral agent, Entecavir (E558900).

2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one Preparation Products And Raw materials

Raw materials

Benzene, [(2,4-cyclopentadien-1-ylmethoxy)methyl]- (2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-(benzyloxy)-9H-purin-9-yl]-2-(benzyloxymethyl)cyclopentanone (1S,2R,3S,5R)-2-(Benzyloxymethyl)-6-oxabicyclo[3.1.0]hexan-3-ol SODIUM CYCLOPENTADIENIDE (1S,2R,3S,5R)-3-(Phenymethyloxy)-2-(phenylmethoxy)methyl-6-oxabicyclo[3.1.0]hexane

6-(Benzyloxy)-9-((1S,3S)-4-(benzyloxy)-3-((benzyloxy)methyl)-2-methylenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine (1S, 2R)-2-(Benzyloxymethyl)-1-hydroxy-3-cyclopentene (2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-(phenylmethoxy)-9H-purin-9-yl]-2-(benzyloxymethyl)cyclopentanol (1S,2S,3S,5S)-5-(2-Amino-6-(benzyloxy)-9H-purin-9-yl)-3-(benzyloxy)-2-(benzyloxymethyl)cyclopentanol Benzyl chloromethyl ether

Triethyl orthoformate

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Preparation Products

2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one Suppliers

Global( 200)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Trignokem International	+91 (40) 2717-0709	New Delhi, India	380	50	Inquiry
Manus Aktteva	+91 (79) 6512-3395	New Delhi, India	581	34	Inquiry
KKyemistry (India) Pvt. Ltd.	+91 (40) 2351-0950	New Delhi, India	197	50	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	China	20296	58	Inquiry
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	China	16920	58	Inquiry
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	China	21669	55	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry

Supplier	Advantage
Trignokem International	50
Manus Aktteva	34
KKyemistry (India) Pvt. Ltd.	50
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Henan Fengda Chemical Co., Ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60

142217-81-0(2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one)Related Search:

EC 2.6.1.2 TERT-AMYL METHYL ETHER Methyl salicylate Kresoxim-methyl 4-Methoxybenzylchloride

Methyl acetate Tribenuron methyl Thiophanate-methyl Cyclopentyl methyl ether Acetaminophen

METSULFURON METHYL (1S,2R,3S,5R)-3-(Phenymethyloxy)-2-(phenylmethoxy)methyl-6-oxabicyclo[3.1.0]hexane Methyl Entecavir hydrate 6-(Benzyloxy)-9-[(1S,3R,4S)-2-methylene-4-(phenylmethoxy)-3-[(phenylmethoxy)methyl]cyclopentyl]-9H-purine-2-amine

(1S,2S,3S,5S)-5-(2-Amino-6-(benzyloxy)-9H-purin-9-yl)-3-(benzyloxy)-2-(benzyloxymethyl)cyclopentanol 6-(Benzyloxy)-9-((1S,3S)-4-(benzyloxy)-3-((benzyloxy)methyl)-2-methylenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine 2-AMino-1,9-dihydro-9-[(1S,3R,4S)-4-(hydroxydiMethylsilyl)-3-(hydroxyMethyl)-2-Methylenecyclopentyl]-6H-purin-6-one

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Entecavir InterMediate VIII IsoMer Entecavir InterMediate N-1 [1S-(1α,3α,4β)]-2-AMino-1,9-dihydro-9-[2-Methylene-4-(phenylMethoxy)-3-[(phenylMethoxy)Methyl]cyclopentyl]-6H 2-AMino-1,9-dihydro-9-[(1S,3R,4S)-2-Methylene-4-(phenylMethoxy)-3-[(phenylMethoxy)Methyl]cyclopentyl]-6H-purin-6-one 3',5'-Di-O-benzyl Entecavir 2-AMino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxyMethyl)-2-Methylenecyclopentyl]-6H-purin-6-one (interMediate 7) 2-AMino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxyMethyl)-2-Methylenecyclopentyl]-6H-purin 2-Amino-9-((1S,3R,4S)-4-(benzyloxy)-3-((benzyloxy)-methyl)-2-methylenecyclopentyl)-1H-purin-6(9H) 6H-Purin-6-one,2-amino-1,9-dihydro-9[(1S,3R,4S)-2-methylene-4-(phenylmethoxy)-3-[([phenylmethoxy)methyl]cyclopentyl]- N-1 Entecavir API 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl]-6H-p Entecavir dibenzylated 2-Amino-9-((1S,3R,4S)-4-(benzyloxy)-3-((benzyloxy)-methyl)-2-methylenecyclopentyl)-1H-purin-6( (1S,3R,4S)-2-amino-9-[4-(benzyloxy)-3-(benzyloxymethyl)-2-methylidene-cyclopentyl]-3H-purin-6-one 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one Entecavir-9 2-amino-9-((1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl)-1H-purin-6(9H)-one Entecavir E8 2-AMINO-9-((1S,3R,4S)-4-(BENZYLOXY)-3-(BENZYLOXYMETHYL)-2-METHYLENECYCLOPHENTYL)-1H-PURIN-6(9H)-ONE 2-aMino-9-((1S,3R,4S)-4-(benzyloxy)-3-(benzyloxyMethyl)-2-Methylenecyclopentyl)-9H-purin-6-ol 2-aMino-9-((1S,3R,4S)-4-(benzyloxy)-3-(benzyloxyMethyl)-2-Methylenecyclopentyl)-1H-[(13)C4]purin-6(9H)-one Entecavir Impurity 4 Dibenzyl Entecavir Dibenzyl Entecavir (3',5'-Di-O-Benzyl Entecavir) 2-amino-9-[(1S,3R,4S)-4-(benzyloxy)-3-[(benzyloxy)methyl]-2-methylidenecyclopentyl]-9H-purin-6-ol ETA/ET1/N8 Entecavir impurity SRR Entecavir Dibenzyl Impurity 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-Chemicalbook(benzyloxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxy... US-DMF No.: 026257 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)- 2-methylenecyclopentyl]-6H- 2-aMino-1,9-dihydro-9-[(1S,3R,4S)-2-Methylene-4-(benzyloxy)-3-[(benzyloxy)Methyl]cyclopentyl]-6H-Purin-6-one DIBENZYLOXY GUANINE INTERMEDIATE 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4- (benzyloxy)-3- (benzyloxymethyl)-2-methylenecyclopentyl]}6H- purin-6-one(Ent-VIII) 2-Amino-1,9-dihydro-9- [(1S, 3R, 4S) -4-benzyloxy-3-benzyloxymethyl-2-methylenecyclopentyl] -6H-purine-6-one Dibenzyl Entecavir (3',5'-Di-O-Benzyl Entecavir) 142217-81-0 142271-81-0 142214-77-4