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11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE

11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE Structure
CAS No.
102394-31-0
Chemical Name:
11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE
Synonyms
AF-DX 116;Brn 4212983;(100158-38-1) otenzepad;ethyl)-7-piperidinyl)acetyl)-;Muscarinic acetylcholine receptor,Otenzepad,Inhibitor,mAChR,inhibit,memory;6h-pyrido(2,3-b)(1,4)benzodiazepin-6-one,5,11-dihydro-11-((2-((diethylamino)m;11-(2-(2-((Diethylamino)methyl)piperidin-1-yl)acetyl)-5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one;11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE;11-[2-[2-[(Diethylamino)methyl]-1-piperidinyl]acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one;6H-Pyrido(2,3-B)(1,4)benzodiazepin-6-one, 5,11-dihydro-11-((2-((diethylamino)methyl)-7-piperidinyl)acetyl)-
CBNumber:
CB1242627
Molecular Formula:
C24H31N5O2
Molecular Weight:
421.54
MOL File:
102394-31-0.mol
MSDS File:
SDS
Modify Date:
2023/9/4 15:50:00
Request For Quotation

11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE Properties

Boiling point 573.2±45.0 °C(Predicted)
Density 1.171
storage temp. room temp
solubility DMSO: soluble5mg/mL (clear solution; warmed)
pka 11.29±0.20(Predicted)
form powder
color white to beige

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P233-P260-P261-P264-P271-P280-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3
NFPA 704
0
1 0

11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SML0435 AF-DX 116 ≥98% (HPLC) 102394-31-0 5MG ₹10846.65 2022-06-14 Buy
Sigma-Aldrich(India) SML0435 AF-DX 116 ≥98% (HPLC) 102394-31-0 25MG ₹43527.33 2022-06-14 Buy
Sigma-Aldrich(India) 5.05821 AF-DX 116 - CAS 102394-31-0 - Calbiochem 102394-31-0 10MG ₹18740 2022-06-14 Buy
Product number Packaging Price Buy
SML0435 5MG ₹10846.65 Buy
SML0435 25MG ₹43527.33 Buy
5.05821 10MG ₹18740 Buy

11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE Chemical Properties,Uses,Production

Uses

AF-DX 116 has been used as an M2 muscarinic acetylcholine receptor (M2AChR) selective antagonist to study the influence of M2AChR in the regulation of both basal and carbachol-stimulated long-term potentiation at the dentate gyrus (DG-LTP) and pro-nerve growth factor (proNGF) secretion in hippocampal cells of young diabetic rats.

Biological Activity

Selective M 2 muscarinic receptor antagonist. K i values are 64, 417, 786, 211 and 5130 nM for human recombinant M 2 , M 1 , M 3 , M 4 and M 5 muscarinic receptors, respectively.

Biochem/physiol Actions

AF-DX 116 raises blood pressure and heart rate in a rat model of hypotension induced by repeated cold stress. Thus, it may be used as a therapeutic for hypotension related to vagotonia type autonomic dysfunction.

11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE Suppliers

Global( 54)Suppliers
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ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Cayman Chemical Company (800) 364-9897 United States 6618 81 Inquiry
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 China 8740 58 Inquiry
BOC Sciences USA 0 65 Inquiry
HangZhou YuHao Chemical Technology Co., Ltd. 0571-82693216 China 2031 58 Inquiry
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136 China 9863 58 Inquiry
Shanghai Hao Biological Technology Co., Ltd. 021-58116080 18019263206 CHINA 6921 58 Inquiry
Beijing Taize Ruida Technology Co., Ltd. 400-800-8151 13651185998 CHINA 6536 58 Inquiry
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 60
CONIER CHEM AND PHARMA LIMITED 58
TargetMol Chemicals Inc. 58
Cayman Chemical Company 81
Shanghai Yifei Biotechnology Co. , Ltd. 58
BOC Sciences 65
HangZhou YuHao Chemical Technology Co., Ltd. 58
Shanghai Chaolan Chemical Technology Center 58
Shanghai Hao Biological Technology Co., Ltd. 58
Beijing Taize Ruida Technology Co., Ltd. 58

11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE Spectrum

11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE(102394-31-0)1HNMR

102394-31-0(11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE)Related Search:

Hexamethyldisilazane CHEMBRDG-BB 4015189 DIMETHYL-PIPERIDIN-2-YLMETHYL-AMINE 1-ethylpiperidine-2-methylamine C-(1-METHYL-PIPERIDIN-2-YL)-METHYLAMINE
Methyl[(1-methylpiperidin-2-yl)methyl]amine 3-Amino-2-phenylamino-pyridine ETHYL[(1-METHYLPIPERIDIN-2-YL)METHYL]AMINE 5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one ETHYL[(1-ETHYLPIPERIDIN-2-YL)METHYL]AMINE
2-(2-methylpiperidin-1-yl)ethanamine 2-amino-N-(3-pyridinyl)benzamide (1-ETHYL-2-PIPERIDINYL)-N-METHYLMETHANAMINE 2-(2-DIETHYLAMINOETHYL)PIPERIDINE 11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE
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11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE AF-DX 116 6h-pyrido(2,3-b)(1,4)benzodiazepin-6-one,5,11-dihydro-11-((2-((diethylamino)m ethyl)-7-piperidinyl)acetyl)- 11-((2-((Diethylamino)methyl)-1-piperidinyl)acetyl)-5,11-dihydro-(6H)-pyrido[2.3-b][1.4]benzodiazepin-6-one 6H-Pyrido(2,3-B)(1,4)benzodiazepin-6-one, 11-((2-((diethylamino)methyl)-1-piperidinyl)acetyl)-5,11-dihydro- 6H-Pyrido(2,3-B)(1,4)benzodiazepin-6-one, 5,11-dihydro-11-((2-((diethylamino)methyl)-7-piperidinyl)acetyl)- Brn 4212983 11-[2-[2-[(Diethylamino)methyl]-1-piperidinyl]acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one 11-(2-(2-((Diethylamino)methyl)piperidin-1-yl)acetyl)-5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one (100158-38-1) otenzepad 6H-Pyrido[2,3-b][1,4]benzodiazepin-6-one, 11-[2-[2-[(diethylamino)methyl]-1-piperidinyl]acetyl]-5,11-dihydro- Muscarinic acetylcholine receptor,Otenzepad,Inhibitor,mAChR,inhibit,memory 102394-31-0 C24H31N5O2 Acetylcholine receptor Muscarinic