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ChemicalBook > Product Catalog >Pharmaceutical intermediates >Bulk Drug Intermediates >(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran

(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran

(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Structure
CAS No.
915095-94-2
Chemical Name:
(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran
Synonyms
EMpagliflozin iMpurity C;(S)-4-iodo-1-chloro-2-(4-tetrahydrofuran-3-yloxy-benzyl)-benzene;]phenoxy}oxoL;oro-5-iodophenyL;(3S)-3-{4-[(2-chL;Englitin Impurity 28;Empagliflozin Impurity 110;Empagliflozin Intermediate1;(3S)-3-[4-[(2-Chloro-5-iodophenyl) methyl] phenc;1-chloro-2-(4-(cyclopentyloxy)benzyl)-4-iodobenzene
CBNumber:
CB12657939
Molecular Formula:
C17H16ClIO2
Molecular Weight:
414.67
MOL File:
915095-94-2.mol
MSDS File:
SDS
Modify Date:
2024/7/9 21:58:15
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(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Properties

Boiling point 476.0±45.0 °C(Predicted)
Density 1.578±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. 2-8°C(protect from light)
solubility DMSO, Methanol (Slightly, Sonicated)
form Solid
color White to Off-White
InChI InChI=1S/C17H16ClIO2/c18-17-6-3-14(19)10-13(17)9-12-1-4-15(5-2-12)21-16-7-8-20-11-16/h1-6,10,16H,7-9,11H2/t16-/m0/s1
InChIKey YLUHNGIWRCCQMQ-INIZCTEOSA-N
SMILES O1CC[C@H](OC2=CC=C(CC3=CC(I)=CC=C3Cl)C=C2)C1
CAS DataBase Reference 915095-94-2

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Chemical Properties,Uses,Production

Description

(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran is a pharmaceutical intermediate compound that is used in the preparation of empagliflozin. Empagliflozin is an inhibitor of sodium-glucose co-transporter protein-2 (SGLT2), which is used in the treatment of type 2 diabetes.

Preparation

0.5 mol of raw material and 0.6 mol of aluminum chloride were added to 2 mol of methanol at a temperature of 20° C, and then 0.6 mol of triethylsilane was added to the mixed solution. The mixture was stirred at 25° C for 1 h.The conversion is determined by HPLC analysis. After the reaction is complete, it is extracted and distilled under reduced pressure.Finally, (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan was obtained through purification.  
(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan

(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Preparation Products And Raw materials

Raw materials

4-Hydroxybenzyl chloride 4-(2-chloro-5-iodobenzyl)phenol 2-Chloro-5-iodobenzoic acid 2-Chloro-5-iodo-benzoyl chloride Empagliflozin Impurity 35
(2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone (S)-3-P-MESYLOXYTETRAHYDROFURAN (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone 4-Methoxybenzylchloride 4-Iodoaniline
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Preparation Products

1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((S)-tetrahydrofuran-3-yloxy)benzyl]benzene

(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Suppliers

Global( 375)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Dynarx Technology India Limited +91-9960099480 +91-9960099480 Bangalore, India 71 58 Inquiry
Aastrid Life Sciences Private Limited +91-91-22-40072626 +91-7304494278 Mumbai, India 95 58 Inquiry
A.R. LIFE SCIENCES PVT. LTD. +91-914040267679 +91-8519993257 Hyderabad, India 100 58 Inquiry
Shree Jaya Laboratories Pvt. Ltd. +91-91-40-29881167 +91-9966167167 Hyderabad, India 78 58 Inquiry
PALEM ORGANICS PVT LTD +91-9573728990 +91-9573728990 Hyderabad, India 30 58 Inquiry
Viyash Life Sciences Pvt Ltd +91-4023635052 +91-4023635052 Telangana, India 213 58 Inquiry
Aarti Industries Limited (AIL) +91-84596144931 +91-9920899935 Maharashtra, India 235 58 Inquiry
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Stereokem Pvt Ltd +91-4029706929 +91-9394224843 Telangana, India 350 58 Inquiry
Bakul Pharma Private Limited +91-2261697900 +91-2261697900 Maharashtra, India 66 58 Inquiry
Supplier Advantage
Dynarx Technology India Limited 58
Aastrid Life Sciences Private Limited 58
A.R. LIFE SCIENCES PVT. LTD. 58
Shree Jaya Laboratories Pvt. Ltd. 58
PALEM ORGANICS PVT LTD 58
Viyash Life Sciences Pvt Ltd 58
Aarti Industries Limited (AIL) 58
Lakshmi Farmachem 58
Stereokem Pvt Ltd 58
Bakul Pharma Private Limited 58

(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Spectrum

(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan(915095-94-2)1HNMR

915095-94-2((S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran)Related Search:

(S)-(5-broMo-2-chlorophenyl)(4-(tetrahydrofuran-3-yloxy)phenyl)Methanone (3S,4R)-4-(4-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine Thiazole Copper(II) chloride dihydrate Tetrahydrofuran
Dimethyl fumarate 1-Propanol Brexpiprazole Intermediate 1 (R)-3-(p-toluenesulfonyl) oxytetrahydrofuran Empagliflozin
(S)-(+)-3-Hydroxytetrahydrofuran 4-(5-broMo-2-chlorobenzyl)phenol (3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]- (2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone
(2S,3R,4S,5S,6R)-2-(3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)-4-chlorophenyl)-tetrahydro-6-(hydroxyMethyl)-2-Methoxy-2H-pyran-3,4,5-triol 2,3,4,6-Tetra-O-benzyl-a-D-glucopyranosylbromide (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
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(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan (S)-3-(4-(2-chloro-5-iodobenzyl)phenoxy)-tetrahydrofuran (S)-3-(4-(2-chloro-5-fluorobenzyl)phenoxy)-tetrahydrofuran (3S)-3-{4-[(2-chloro-5-iodophenyl)methyl]phenoxy}oxolane (3S)-3-[4-(2-chloro-5-iodobenzyl)-phenoxy]-tetrahydrofuran Furan, 3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-, (3S)- Empagliflozin Intermediate1 3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan (3S-3-(4)Chloro-5-Iodophenyl)Methyl)Phenoxy)Tetrahydro-Furan 1-chloro-2-(4-(cyclopentyloxy)benzyl)-4-iodobenzene Englitin Impurity 28 (3S)-3-{4-[(2-chL ]phenoxy}oxoL oro-5-iodophenyL (3S)-3-[4-[(2-CHLORO-5-IODOPHENYL)METHYL]PHENOXY]TETRAHYDRO-FURAN 915095-94-2 (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan(For export only) (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan ISO 9001：2015 REACH Empagliflozin Impurity 110 (3S)-3-[4-[(5-Iodo-2- Chlorophenyl) Methyl] Phenoxy] Tetrahydrofuran (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-... EMpagliflozin iMpurity C (S)-4-iodo-1-chloro-2-(4-tetrahydrofuran-3-yloxy-benzyl)-benzene Empagliflozin Intermediate/ (3S)-3-[4-[(2-Chloro-5-Iodophenyl)Methyl]Phenoxy]Tetrahydro-Furan (3S)-3-[4-4(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan (3S)-3-[4-[(2-Chloro-5-iodophenyl) methyl] phenc 915095-94-2 C17H16ClIO2 Empagliflozin Empagliflozin Intermediate 915095-94-2