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Gefitinib-d6

Gefitinib-d6 Structure
CAS No.
1228664-49-0
Chemical Name:
Gefitinib-d6
Synonyms
Gefitinib-d6;[2H6]-Gefitinib;Hexadeuterated gefitinib;N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy-1,1,2,2,3,3-d6]-4-quinazolinamine
CBNumber:
CB12674404
Molecular Formula:
C22H24ClFN4O3
Molecular Weight:
446.91
MOL File:
1228664-49-0.mol
Modify Date:
2024/7/2 8:55:00
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Gefitinib-d6 Properties

storage temp. Store at -20°C
solubility DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 0.3 mg/ml
form A solid
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319
Precautionary statements  P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P501
NFPA 704
0
3 0

Gefitinib-d6 Chemical Properties,Uses,Production

Description

Gefitinib-d6 is intended for use as an internal standard for the quantification of gefitinib by GC- or LC-MS. Gefitinib is an EGFR inhibitor (IC50s = 0.023-0.079 μM). It inhibits colony formation of GEO colon, ZR-75-1 and MCF-10A breast, and OVCAR-3 ovarian cancer cell lines in soft agar assays (IC50s = 0.2-0.4 μM). Gefitinib (0.1 to 1 μM) induces apoptosis and inhibits EGFR autophosphorylation in the same cells. In vivo, gefitinib (1.25, 2.5, and 5 mg/kg) reduces tumor volume and increases survival in a GEO mouse xenograft model. Formulations containing gefitinib have been used in the treatment of non-small cell lung cancer (NSCLC).

Uses

Gefitinib-d6 is the labeled version of Gefitinib (G304000), which is an antineoplastic.

Gefitinib-d6 Preparation Products And Raw materials

Raw materials

Preparation Products

Gefitinib-d6 Suppliers

Global( 15)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 13028896684 China 56070 58 Inquiry
Shanghai Hao Zhun Biological Technology Co., Ltd. 15800340161 CHINA 6846 58 Inquiry
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 China 11289 58 Inquiry
United States Biological 800.520.3011 or 781.639.5092 United States 6256 80 Inquiry
Nanjing XiZe Biotechnology CO., Ltd. 025-58362220 15250997978 China 7774 55 Inquiry
Shanghai isotope chemical co.,ltd 021-021-51600108 13062666369 China 4274 58 Inquiry
S.Z. PhyStandard Bio-Tech. Co., Ltd. 0755-4000505016 13380397412 China 5059 50 Inquiry
Cayman Chemical Company (800) 364-9897 United States 6618 81 Inquiry
Shanghai Beiwanta Biotechnology Co., Ltd. 021-67187366 19901745723 China 9255 58 Inquiry
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 China 8739 58 Inquiry
Supplier Advantage
Shenzhen Polymeri Biochemical Technology Co., Ltd. 58
Shanghai Hao Zhun Biological Technology Co., Ltd. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
United States Biological 80
Nanjing XiZe Biotechnology CO., Ltd. 55
Shanghai isotope chemical co.,ltd 58
S.Z. PhyStandard Bio-Tech. Co., Ltd. 50
Cayman Chemical Company 81
Shanghai Beiwanta Biotechnology Co., Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58

1228664-49-0(Gefitinib-d6)Related Search:

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Gefitinib-d6 Hexadeuterated gefitinib [2H6]-Gefitinib N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy-1,1,2,2,3,3-d6]-4-quinazolinamine 1228664-49-0