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NORTRIPTYLINE

CAS No.: 72-69-5

Chemical Name:: NORTRIPTYLINE

Synonyms: Aventyl;nortryptyline;C07274;Ateben;Sesaval;Avantyl;lambeck;Lumbeck;Noritren;allegron

CBNumber:: CB1317147

Molecular Formula:: C19H21N

Molecular Weight:: 263.38

MOL File:: 72-69-5.mol

Modify Date:: 2024/7/2 8:55:00

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NORTRIPTYLINE Properties

Melting point	58 °C
Boiling point	396.62°C (rough estimate)
Density	0.9790 (rough estimate)
refractive index	1.4900 (estimate)
storage temp.	4°C, protect from light
pka	pKa 9.7 (Uncertain)
form	Solid
color	White to off-white
BCS Class	1
EPA Substance Registry System	Nortriptyline (72-69-5)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P264-P270-P301+P312-P330-P501
Toxicity	LD50 orl-rat: 502 mg/kg HEPHD2 55,527,80

NORTRIPTYLINE Chemical Properties,Uses,Production

Uses

Nortriptyline is a drug with a relatively short latent period of action. It is practically devoid of sedative effects. It is used in manic-depressive psychoses, in all forms of endogenous depression, and also in major depressive conditions.

Definition

ChEBI: An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline.

Safety Profile

Poison by ingestion,intraperitoneal, and intravenous routes. When heated todecomposition it emits toxic fumes of NOx.

Metabolism

Nortriptyline is a secondary amine dibenzocycloheptene TCA as well as the major metabolite of amitriptyline. Similar to desipramine, nortriptyline appears in mother's milk and is metabolized by CYP2D6 to the primary amine and by ring hydroxylation to its E-10-hydroxy metabolite. Approximately one-third of a dose of nortriptyline is excreted in urine as metabolites within 24 hours, and small amounts are excreted in feces via biliary elimination.

NORTRIPTYLINE Preparation Products And Raw materials

Raw materials

Methylamine

Preparation Products

NORTRIPTYLINE Suppliers

Global( 46)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
AKASH PHARMA EXPORTS	+91-9388123451 +91-9846039283	Kerela, India	470	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6522	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Indexim International	08048971004	Gujarat, India	112	58	Inquiry
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	China	5873	58	Inquiry
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	China	9343	55	Inquiry
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	China	2931	58	Inquiry
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	China	30250	58	Inquiry
AFINE CHEMICALS LIMITED	+86-0571-85134551	China	15395	58	Inquiry

Supplier	Advantage
AKASH PHARMA EXPORTS	58
CLEARSYNTH LABS LTD.	58
SynZeal Research Pvt Ltd	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Indexim International	58
Hebei Yanxi Chemical Co., Ltd.	58
Hangzhou FandaChem Co.,Ltd.	55
SHANDONG ZHI SHANG CHEMICAL CO.LTD	58
Career Henan Chemica Co	58
AFINE CHEMICALS LIMITED	58

72-69-5(NORTRIPTYLINE)Related Search:

Cotriptyline Amitriptyline hydrochloride NORTRIPTYLINE PIROHEPTINE nortriptyline hydrochloride methanol*solution,NORTRIPTYLINE HCL USP,Nortriptyline solution hydrochloride,NORTRIPTYLINE HYDROCHLORIDE,NORTRIPTYLINE HCL

Amitriptyline AMITRIPTYLINE HCL (D6) AMITRIPTYLINE-D3 HCL (N-METHYL-D3) cyproheptadine 10,11-epoxide NORTRIPTYLINE METABOLITE (+/-)-(Z),NORTRIPTYLINE METABOLITE (+/-)-Z-10-HYDR OXYLAT

AMITRIPTYLINE METABOLITE (+/-)- amitriptyline N-oxide Piroheptine NORTRIPTYLINE-D3 HYDROCHLORIDE NORTRIPTYLINE HCL (METHYL-D3),NORTRIPTYLINE-D3 HYDROCHLORIDE,NORTRIPTYLINE HCL (D3),NORTRIPTYLINE-D3 HCL (N-METHYL-D3)

Nortriptyline-d3 HCl cis-10,11-Dihydroxy Nortriptyline 10,11-DIHYDRO-5 H-DIBENZO[A,D]CYCLOHEPTENE

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5-(alpha-methylaminopropylidene)dibenzo[a,d]cyclohepta[1,4]diene 5-[3-(Methylamino)propylidene]dibenzo[a,E]cyclohepta[1,5]diene Noramitriptyline Noritren Nortryptiline Psychostyl Sesaval NORTRIPTYLINE N-[3-(10,11-DIHYDRO-5H-DIBENZO[A,D][7]ANNULEN-5-YLIDENE)PROPYL]-N-METHYLAMINE HYDROCHLORIDE 10,11-dihydro-5-(3-methylaminopropylidene)dibenzo(a,d)cycloheptene demethylamitryptylene demethyl-amitryptylin Demethylamitryptyline Desitriptilina Desmethylamitriptyline 10,11-dihydro-5-(3-methylaminopropylidene)-5h-dibenzo[a,d][1,4]cycloheptene 10,11-Dihydro-N-methyl-5H-dibenzo(a,d)cycloheptane-delta,gamma-propylamine 10,11-dihydro-n-methyl-5h-dibenzo(a,d)cycloheptene-delta(5,gamma)-propylamin 10,11-dihydro-n-methyl-5h-dibenzo[a,d]cycloheptene-delta(5,gamma)-propylamine 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl- 1-propanamine,3-(10,11-dihydro-5h-dibenzo(a,d)cycloheptene-5-ylidene)-n-methyl Nortrityline C07274 5h-dibenzo(a,d)cycloheptene-delta(5,gamma)-propylamine,10,11-dihydro-n-methyl 5H-Dibenzo[a,d]cycloheptene-delta5,gamma-propylamine, 10,11-dihydro-N-methyl- allegron Amitryptyline, demethyl- Ateben Avantyl Demethylamitriptylene Demethylamitriptyline 3-(10,11-dihydro-5h-dibenzo[a,d]-cyclohepten-5-ylidene)-n-methyl-1-propanamine 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine 3-(10,11-dihydro-5h-dibenzo[a,d]cyclohepten-5-ylidene)-n-methylpropylamine 5-(3-(methylamino)propylidene)dibenzo(a,e)cyclohepta(1,5)diene 5-(3-Methylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene lambeck Lumbeck Amitriptyline EP Impurity C NORTRIPTYLINE USP/EP/BP nortryptyline Aventyl Nortriptylene c.3-(10,11-dihydro-5h-dibenzo[a,d][7]annulen-5-ylidene)-N-methylpropan-1-amine(nortriptyline), 72-69-5 84-71-3