Amitriptyline hydrochloride
- CAS No.
- 549-18-8
- Chemical Name:
- Amitriptyline hydrochloride
- Synonyms
- AMITRIPTYLINE HCL;amitid;endep;Amitriptyline Hydrochloride (200 mg);deprex;Normaln;Amiplin;domical;etrafon;saroten
- CBNumber:
- CB1252307
- Molecular Formula:
- C20H24ClN
- Molecular Weight:
- 313.86
- MOL File:
- 549-18-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/3/16 7:03:48
| Melting point | 196-197°C |
|---|---|
| Flash point | 11 °C |
| storage temp. | 2-8°C |
| solubility | H2O: soluble |
| form | powder |
| pka | 9.4(at 25℃) |
| color | white to off-white |
| PH | 4.5～6.0 (10g/l, 25℃) |
| Water Solubility | almost transparency |
| Merck | 14,487 |
| BCS Class | 1 |
| CAS DataBase Reference | 549-18-8(CAS DataBase Reference) |
| EPA Substance Registry System | Amitriptyline hydrochloride (549-18-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS06,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H319-H361d-H410 | |||||||||
| Precautionary statements | P202-P264-P270-P273-P301+P310-P305+P351+P338 | |||||||||
| Hazard Codes | T,F,N,Xn | |||||||||
| Risk Statements | 23/24/25-36/37/38-42/43-63-39/23/24/25-11-50/53-36-22 | |||||||||
| Safety Statements | 22-26-36/37/39-45-36/37-16-61-60-7 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | HO9450000 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29214990 | |||||||||
| Toxicity | LD50 in mice, rats (mg/kg): 350, 380 orally; 65, 75 i.p. (Tobe) | |||||||||
| NFPA 704 |
|
Amitriptyline hydrochloride price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | A8404 | Amitriptyline hydrochloride ≥98% (TLC), powder | 549-18-8 | 10G | ₹5304.25 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1384 | Amitriptyline hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material | 549-18-8 | 1G | ₹7609.98 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A8404 | Amitriptyline hydrochloride ≥98% (TLC), powder | 549-18-8 | 25G | ₹10662.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A8404 | Amitriptyline hydrochloride ≥98% (TLC), powder | 549-18-8 | 100G | ₹28578 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A-923 | Amitriptyline hydrochloride solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? | 549-18-8 | 1ML | ₹2407.3 | 2022-06-14 | Buy |
Amitriptyline hydrochloride Chemical Properties,Uses,Production
Description
Amitriptyline (hydrochloride) (CRM) (Item No. 19031) is a certified reference material categorized as a tricyclic antidepressant. This product is intended for analytical forensic applications. This product is also available as a general research tool .
Chemical Properties
White to Off-White Solid
Uses
Amitriptyline hydrochloride is a tricyclic antidepressant drug. Amitriptyline hydrochloride inhibits the norepinephrine and serotonin transporters but has a high affinity for α1-adrenergic, serotonin and muscarinic acetylcholine receptors.
General Description
Amitriptyline, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine hydrochloride,5-(3-dimethylaminopropylidene)-10,11-dihydro-5Hdibenzo[a,d]cycloheptene hydrochloride (Elavil), is one ofthe most anticholinergic and sedative of the TCAs. Becauseit lacks the ring-electron–enriching nitrogen atom ofimipramine, metabolic inactivation mainly proceeds not at theanalogous 2-position but at the benzylic 10-position (i.e.,toluene-like metabolism predominates). Because of the 5-exocyclic double bond, E- and Z-hydroxy isomers are producedby oxidation metabolism. Conjugation produces excretablemetabolites. As is typical of the dimethyl compounds,N-demethylation occurs, and nortriptyline is produced, whichhas a less anticholinergic, less sedative, and more stimulantaction than amitriptyline. Nortriptyline is a SNERI; thecomposite action of drug and metabolite is nonselective.
Safety Profile
Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Human systemic effects by ingestion: convulsions, respiratory depression, changes in sleep, hallucinations, muscle contractions, somnolence, blood pressure decrease, coma, cyanosis, dyspnea, and ataxia. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. Used in the treatment of depression. When heated to decomposition it emits very toxic fumes of HCl and NOx. See also ELAVIL.
Amitriptyline hydrochloride Preparation Products And Raw materials
Raw materials
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| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| R L Fine Chem Pvt. Ltd | +91-8042488999 +91-8042488999 | Karnataka, India | 74 | 58 | Inquiry |
| Mankind Pharma Limited | +91-1146541111 +91-1146541111 | New Delhi, India | 23 | 58 | Inquiry |
| HRV Global Life Sciences | +91-9820219686 +91-9820219686 | Telangana, India | 379 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | +91-26463395 +91-7926462688 | Gujarat, India | 1615 | 58 | Inquiry |
| S D Fine Chem Limited | +91-9323715856 +91-9323715856 | Maharashtra, India | 368 | 58 | Inquiry |
| SL Drugs and Pharmaceuticals Pvt. Ltd. | +91 (40) 6661-1133 | New Delhi, India | 2688 | 50 | Inquiry |
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |
| Medilink Pharmachem | +91 (79) 3007-0133 | New Delhi, India | 424 | 50 | Inquiry |
| SUN PHARMACEUTICAL INDUSTRIES LTD | (+91 22) 4324 4324 | New Delhi, India | 175 | 58 | Inquiry |
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