Zileuton
- CAS No.
- 111406-87-2
- Chemical Name:
- Zileuton
- Synonyms
- ZYFLO;Zyfl;Leutml;ABT-077;Leutrol; A-64077;ZILEUTON;CGS-23622;Griluto-CR;AKOS 91253
- CBNumber:
- CB1344903
- Molecular Formula:
- C11H12N2O2S
- Molecular Weight:
- 236.29
- MOL File:
- 111406-87-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
| Melting point | 157-158°C |
|---|---|
| Boiling point | 449.4±47.0 °C(Predicted) |
| Density | 1.401±0.06 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | DMSO: ≥20mg/mL at ~60°C (warm up to 60 C for 5min) |
| pka | pKa 10.3(H2O t undefined I undefined) (Uncertain) |
| form | powder |
| color | white to off-white |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| CAS DataBase Reference | 111406-87-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H361d | |||||||||
| Precautionary statements | P202-P264-P270-P280-P301+P312-P308+P313 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 1 | |||||||||
| HS Code | 2934990002 | |||||||||
| NFPA 704 |
|
Zileuton price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | Z4277 | Zileuton ≥98% (HPLC) | 111406-87-2 | 10MG | ₹8746.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | Z4277 | Zileuton ≥98% (HPLC) | 111406-87-2 | 50MG | ₹34401.85 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR2555 | Zileuton | 111406-87-2 | 200MG | ₹15847.8 | 2022-06-14 | Buy |
Zileuton Chemical Properties,Uses,Production
Description
Zileuton is a reversible 5-lipoxygenase (5-LO) inhibitor. It inhibits 5-LO activity in rat basophilic leukemia-1 (RBL-1) cell supernatant with an IC50 value of 0.5 μM. Zileuton inhibits leukotriene B4 (LTB4; ) production induced by the calcium ionophore A23187 in purified human peripheral blood polymorphonuclear leukocytes (PMNLs; IC50 = 0.6 μM). Zileuton (10 mg/kg, p.o.) prevents antigen challenge-induced increases in specific lung resistance in a sheep model of asthma at 4 to 8 hours post-challenge following administration 2 hours pre-challenge. Formulations containing zileuton have been used in the prophylaxis and chronic treatment of asthma.
Chemical Properties
Crystalline Solid
Definition
ChEBI: A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogen at position 2 is replaced by a 1-[carbamoyl(hydroxy)amino]ethyl group. A selective 5-lipoxygenase inhibitor, it inhibits the formation of leukotrienes LTB4, LTC4, LDT , and LTE4. It is used for the management of chronic asthma.
Biological Activity
Orally active 5-lipoxygenase (5-LOX) inhibitor that inhibits LTB 4 synthesis (IC 50 values are 0.56, 2.3 and 2.6 μ M in dog, rat and human blood respectively). Inhibits antigen-induced contraction of tracheal strips in vitro (IC 50 = 6 μ M) and exhibits antiasthmatic activity in vivo . Also weakly inhibits CYP1A2 (K i = 66 - 98 μ M).
Zileuton Preparation Products And Raw materials
Raw materials
1of2
chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Sekhment pharmaventures | +91-9030088669 +91-9030088669 | Mumbai, India | 105 | 58 | Inquiry |
| Solara Active Pharma Sciences Ltd | +91-8046632100 +91-7075706520 | Bangalore, India | 65 | 58 | Inquiry |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | +91-26463395 +91-7926462688 | Gujarat, India | 1615 | 58 | Inquiry |
| Mylan Laboratories Ltd | +91-4023550543 +91-4030866666 | Telangana, India | 150 | 58 | Inquiry |
| Apicore Pharmaceuticals Pvt Ltd | +91-2662267177 +91-2662267166 | Gujarat, India | 181 | 58 | Inquiry |
| Biophore India Pharmaceuticals Pvt Ltd | +91-9100031592 +91-9030907714 | Telangana, India | 134 | 58 | Inquiry |
| Aspen Biopharma Labs Pvt Ltd | +91-9248058660 +91-9248058662 | Telangana, India | 234 | 58 | Inquiry |
| AKASH PHARMA EXPORTS | +91-9388123451 +91-9846039283 | Kerela, India | 470 | 58 | Inquiry |
| Asara Medi Pharma | 91-8652334554 | Mumbai, India | 124 | 58 | Inquiry |
| Emcure Pharmaceuticals Pvt., Ltd. | 91-20-39821350 Extn 1351 | Maharashtra, India | 18 | 58 | Inquiry |