4-Amino-3-methylphenol
- CAS No.
- 2835-99-6
- Chemical Name:
- 4-Amino-3-methylphenol
- Synonyms
- 4-AMINO-3-METHYLPHENOL;4-AMINO-3-CRESOL;Phenol, 4-amino-3-methyl-;p-Hydroxy-o-toluidine;3-Methyl-4-aminophenol;JAROCOL 4A3MP;4-amino-meta-;Amino-M-Cresol;4-amino-cresol;4-amino-m-creso
- CBNumber:
- CB1365623
- Molecular Formula:
- C7H9NO
- Molecular Weight:
- 123.15
- MOL File:
- 2835-99-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/26 15:15:06
| Melting point | 176-179 °C (lit.) |
|---|---|
| Boiling point | 229.26°C (rough estimate) |
| Density | 1.0877 (rough estimate) |
| refractive index | 1.5380 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | soluble in Methanol |
| form | Powder |
| pka | 10.34±0.18(Predicted) |
| color | Brown |
| Water Solubility | insoluble |
| BRN | 2078803 |
| InChIKey | QGNGOGOOPUYKMC-UHFFFAOYSA-N |
| LogP | 0.51 at 22℃ |
| CAS DataBase Reference | 2835-99-6(CAS DataBase Reference) |
| NIST Chemistry Reference | 4-Amino-3-methyl phenol(2835-99-6) |
| EPA Substance Registry System | Phenol, 4-amino-3-methyl- (2835-99-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H400 | |||||||||
| Precautionary statements | P273-P301+P312+P330-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38-20/21/22 | |||||||||
| Safety Statements | 26-37/39-36/37/39-36-24/25 | |||||||||
| RIDADR | UN3077 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | GO6826000 | |||||||||
| F | 8-10-23 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 9 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29222900 | |||||||||
| NFPA 704 |
|
4-Amino-3-methylphenol price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 144894 | 4-Amino-3-methylphenol 97% | 2835-99-6 | 5G | ₹5758.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 144894 | 4-Amino-3-methylphenol 97% | 2835-99-6 | 25G | ₹11258 | 2022-06-14 | Buy |
| TCI Chemicals (India) | A0288 | 4-Amino-m-cresol min. 98.0 % | 2835-99-6 | 25G | ₹3700 | 2022-05-26 | Buy |
4-Amino-3-methylphenol Chemical Properties,Uses,Production
Description
4-Amino-3-methylphenol is a metabolite of 3-methyl-4-nitrophenol. It is a major metabolite of carcinogenic o-toluidine and causes DNA damage in the presence of Cu(II).
Chemical Properties
Light gray powder
Uses
4-Amino-3-methylphenol is a useful reagent for the synthesis of piperidine (piperazine)-amide substituted derivatives as multi-target antipsychotics.
4-Amino-3-methylphenol was used in synthesis of a new type of tweezer-molecule in which a strongly preferred binding conformation is generated by convergent, intramolecular hydrogen bonding.
Application
4-Amino-m-cresol is used as an oxidative hair dye at a maximum concentration of 1.5% after mixing with peroxide.
Definition
ChEBI: 4-hydroxy-6-methylaniline is a substituted aniline in which the aniline ring carries 4-hydroxy and 6-methyl substituents; a urinary metabolite of lidocaine. It has a role as a drug metabolite. It is a member of phenols and a substituted aniline.
General Description
4-Amino-3-methylphenol is a metabolite of 3-methyl-4-nitrophenol. It is a major metabolite of carcinogenic o-toluidine and causes DNA damage in the presence of Cu(II).
Synthesis
The synthesis of 4-Amino-3-methylphenol is as follows:A mixture of the para-benzoquinone mono-oxime (1.26 mmol),SnCl2 (0.72 g, 3.80 mmol), 20 mL of CH2Cl2, and 0.2 mL of concentrated HCl, was heated to reflux for 16 h. The CH2Cl2 was removed under reduced pressure, and the residue was dissolved in ethyl acetate and washed with concentrated aqueous NaHCO3. The organic layer was dried over anhydrous Na2SO4 and the filtrate was concentrated under reduced pressure to afford the solid product.
Purification Methods
Crystallise it from 50% EtOH. [Beilstein 13 H 593, 13 IV 1698.]
4-Amino-3-methylphenol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Vignasai Laboratories Pvt Ltd | +91-9390048212 +91-9030998889 | Telangana, India | 99 | 58 | Inquiry |
| Krishna Industries | +91-7922822554 +91-7922822554 | Gujarat, India | 235 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Dhruvtara Chemicals Pvt. Ltd. | 91 40 27154607 | New Delhi, India | 180 | 56 | Inquiry |
| Metropolitan Eximchem Pvt., Ltd. (Metropolitan Group) | 91-22-24081528 | Maharashtra, India | 70 | 58 | Inquiry |
| Dhruvtara Chemicals Private Limited | 08048361362Ext 107 | Hyderabad, India | 84 | 58 | Inquiry |
| BLACK ROSE Industries Ltd | +91 43337200 22873022 | Mumbai, India | 28 | 58 | Inquiry |
| Metropolitan Eximchem Limited | +91 22 2408 1528 | Mumbai, India | 48 | 58 | Inquiry |
| Innovative Synthetic Molecules | +91 40-24111684 | Hyderabad, India | 527 | 58 | Inquiry |
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