1,4-Butane sultone
- CAS No.
- 1633-83-6
- Chemical Name:
- 1,4-Butane sultone
- Synonyms
- butanesultone;1,4-BUTANE SULTON;-Sultone;1,4-Butane;butanesulfone;1,4-Butane suL;JACS-1633-83-6;δ-Valerosultone;1,4-Butylsultone;1,4-Butane sultone
- CBNumber:
- CB1497155
- Molecular Formula:
- C4H8O3S
- Molecular Weight:
- 136.17
- MOL File:
- 1633-83-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/30 14:17:11
| Melting point | 12-15 °C (lit.) |
|---|---|
| Boiling point | >165 °C/25 mmHg (lit.) |
| Density | 1.331 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | Store below +30°C. |
| solubility | 54g/l (decomposition) |
| form | Liquid |
| color | Clear colorless to yellow |
| Water Solubility | 54 g/L (20 ºC) decomposes |
| Sensitive | Moisture Sensitive |
| BRN | 110588 |
| InChIKey | MHYFEEDKONKGEB-UHFFFAOYSA-N |
| CAS DataBase Reference | 1633-83-6(CAS DataBase Reference) |
| EPA Substance Registry System | 1,2-Oxathiane, 2,2-dioxide (1633-83-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H317-H319-H335-H351 | |||||||||
| Precautionary statements | P201-P280-P301+P312-P302+P352-P305+P351+P338-P308+P313 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-40-68-20/21/22 | |||||||||
| Safety Statements | 22-36/37-45-36 | |||||||||
| RIDADR | 2810 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | RP4300000 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29349990 | |||||||||
| Toxicity | LD50 orally in Rabbit: 500 mg/kg | |||||||||
| NFPA 704 |
|
1,4-Butane sultone price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | B85501 | 1,4-Butane sultone ≥99% | 1633-83-6 | 25G | ₹2868.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | B85501 | 1,4-Butane sultone ≥99% | 1633-83-6 | 100G | ₹9277.03 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.20665 | 1,4-Butanesultone for synthesis | 1633-83-6 | 50ML | ₹12210.01 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.20665 | 1,4-Butanesultone for synthesis | 1633-83-6 | 250ML | ₹18720 | 2022-06-14 | Buy |
| ALFA India | ALF-L03992-22 | 1,4-Butanesultone, 99% | 1633-83-6 | 100g | ₹9351 | 2022-05-26 | Buy |
1,4-Butane sultone Chemical Properties,Uses,Production
Description
1,4-Butane sultone is an impurity in sulfobutyl ether β-cyclodextrin (SBE-β-CD), and has been reported to be a weak carcinogen. 1,4-Butane sultone can be used for preparation of Br?nsted acidic ionic liquids and the ionic liquid is green, highly water soluble, thermally stable, specific and catalytically stable, and can be used for the preparation of symmetrical 3,3'-diaryloxyoctanone compounds[1-2].
Chemical Properties
Butanesultone is a viscous, clear, colourless – or yellowish/brown – and odourless liquid. When heated, vapours of butanesultone are known to form explosive mixtures with air and are reported to cause explosion hazards.
Uses
1,4-Butane sultone can be employed as a reactant in the preparation of conjugated polymers which include polybetaine, poly[2-ethynyl-N-(4-sulfobutyl)pyridinium betaine] (PESPB).
It can also be used in the preparation of Bronsted acid catalysts such as 4-(succinimido)-1-butane sulfonic acid and poly(4-vinylpyridinium butane sulfonic acid) hydrogen sulfate. These catalysts facilitate the synthesis of 1-amidoalkyl-2-naphthols, substituted quinolines, and pyrano[4,3-b]pyran derivatives.
Uses
1,4-Butane Sultone is an alkylating agent with weak carcinogenic activity.
Application
1,4-Butane sultone is an intermediate widely used for sulfonated surfactants.It is also applied in photo development and electroplating.It is used as the Intermediate for the production of APIs.It used in sulfobutylether-β-cyclodextrin（SEBCD).
Safety Profile
Suspected carcinogen with experimental tumorigenic data. Poison by subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. Experimental reproductive effects. Human mutation data reported. See also SULFONATES. When heated to decomposition it emits toxic fumes of SOx
Synthesis
Performing sulfonation on 3-butylene-1-alcohol or 3-butylene-1-chlorine serving as a raw material and a sulfonating agent under the oxidation-reduction of an initiator;performing acidification after the reaction is finished;performing lactonization by high vacuum dehydration cyclization and azeotropic dehydration cyclization;and finally refining to obtain a 1,4-butane sultone finished product.
References
[1] LAYLA A. TAIB; Mosadegh K. Introduction of novel br?nsted acidic ionic liquids with perchlorate counter-anion for one-pot synthesis of symmetric 3,3′-diaryloxindoles[J]. Research on Chemical Intermediates, 2021. DOI:10.1007/s11164-021-04419-5.
[2] MENG WANG. Determination of Low-ppm Levels of 1,4-Butane Sultone in Sulfobutyl Ether β-Cyclodextrin Using Liquid–Liquid Extraction and GC–MS[J]. Chromatographia, 2012. DOI:10.1007/s10337-012-2275-8.
1,4-Butane sultone Preparation Products And Raw materials
Raw materials
1of3
chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Louis Pharmaceuticals Pvt Ltd | +91-8498087900 +91-8498087900 | Telangana, India | 23 | 58 | Inquiry |
| Varada Pharma Chem Pvt Ltd | +91-09000283007 +91-9000283007 | New Delhi, India | 17 | 58 | Inquiry |
| TEADUS PHARMA PRIVATE LIMITED | +91-9740077663 +91-9740077663 | Telangana, India | 242 | 58 | Inquiry |
| Blue Jet Healthcare Ltd | +91-02222071691 +91-9082861262 | Mumbai, India | 86 | 58 | Inquiry |
| GVSK Pharma Private Limited | 07942560916 | Hyderabad, India | 33 | 58 | Inquiry |
| Valiant Pharmatech | 08047649196 | Hyderabad, India | 16 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Louis Pharmaceuticals Pvt Ltd | 58 |
| Varada Pharma Chem Pvt Ltd | 58 |
| TEADUS PHARMA PRIVATE LIMITED | 58 |
| Blue Jet Healthcare Ltd | 58 |
| GVSK Pharma Private Limited | 58 |
| Valiant Pharmatech | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| A.J Chemicals | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Alfa Aesar | 58 |
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