4-Chloro-1-butanol
- CAS No.
- 928-51-8
- Chemical Name:
- 4-Chloro-1-butanol
- Synonyms
- 4-chlorobutan-1-ol;4-CHLOROBUTANOL;oro-1-butanoL;4-Chlorolbutanol;4-Choro-1-bytanol;4-CHLOROBUTANOL-1;4-Chlorbutan-1-ol;4-chloro-1-butano;4-ChIoro-1-butanoI;4-CHLORO-1-BUTANOL
- CBNumber:
- CB5100347
- Molecular Formula:
- C4H9ClO
- Molecular Weight:
- 108.57
- MOL File:
- 928-51-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/25 20:04:51
| Boiling point | 84-85 °C/16 mmHg (lit.) |
|---|---|
| Density | 1.088 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 97 °F |
| storage temp. | 2-8°C |
| solubility | Soluble in methanol, chloroform, and dimethyl sufoxide. |
| form | Liquid |
| pka | 15.01±0.10(Predicted) |
| color | Clear colorless to light yellow |
| BRN | 1731408 |
| InChIKey | HXHGULXINZUGJX-UHFFFAOYSA-N |
| CAS DataBase Reference | 928-51-8(CAS DataBase Reference) |
| NIST Chemistry Reference | 4-Chloro-1-butanol(928-51-8) |
| EPA Substance Registry System | 1-Butanol, 4-chloro- (928-51-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |     GHS02,GHS05,GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H226-H290-H302-H315-H319-H335-H351 | |||||||||
| Precautionary statements | P202-P210-P301+P312-P303+P361+P353-P305+P351+P338-P308+P313 | |||||||||
| Hazard Codes | Xn,C,F | |||||||||
| Risk Statements | 10-22-36/37/38-20/21/22-34-40 | |||||||||
| Safety Statements | 23-24/25-36/37/39-26-16-36/37 | |||||||||
| RIDADR | UN 2920 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | EL1325000 | |||||||||
| Hazard Note | Harmful | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 3.2 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29055910 | |||||||||
| NFPA 704 |
|
4-Chloro-1-butanol price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemicals (India) | C0144 | 4-Chloro-1-butanol (contains varying amounts of Tetrahydrofuran) min. 85.0 % | 928-51-8 | 25G | ₹4000 | 2022-05-26 | Buy |
| TCI Chemicals (India) | C0144 | 4-Chloro-1-butanol (contains varying amounts of Tetrahydrofuran) min. 85.0 % | 928-51-8 | 500G | ₹41600 | 2022-05-26 | Buy |
4-Chloro-1-butanol Chemical Properties,Uses,Production
Chemical Properties
CLEAR COLOURLESS LIQUID
Uses
4-Chloro-1-butanol is employed as an internal standard in the analysis of genotoxic impurities in active pharmaceutical ingredients by GC-MS technique.
Definition
ChEBI: A primary alcohol that is butan-1-ol substituted by a chloro group at position 4.
General Description
4-Chloro-1-butanol, an alkylating agent, is one of the genotoxic impurity in active pharmaceutical ingredients. Reaction of 4-chloro-1-butanol and Reichardt′s dye has been monitored spectrophotometrically for the determination of genotoxic impurities in pharmaceuticals.
Health Hazard
The toxicity of this compound is low. How ever, the acute toxic symptoms are those ofethylene and propylene chlorohydrins. Oralintake of this compound caused muscle con traction, gastrointestinal pain, ulceration, andliver injury in test animals.
LD50 value, oral (mice): 990 mg/kg
Tetramethylene chlorohydrin caused tumorsin lungs in test animals. Its carcinogenicity,however, is not yet fully established.
Fire Hazard
Flammable; flash point 36°C (97°F); vapor density 3.7 (air = 1); the vapor forms an explosive mixture with air, range is not reported. Fire-extinguishing agent: “alcohol” foam; a water spray may be used to cool fire-exposed containers and to flush any spill. It decomposes to HCl and tetrahydrofuran on heating.
Safety Profile
Moderately toxic by ingestion. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of Cl-. See also CHLORIDES and ALCOHOLS.
Waste Disposal
Tetramethylene chlorohydrin is burned ina chemical incinerator equipped with anafterburner and scrubber.
4-Chloro-1-butanol Preparation Products And Raw materials
Raw materials
Preparation Products
1of2
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| Sris Synthesis Pvt Ltd., | +91-9989522441 +91-9989522441 | Hyderabad, India | 282 | 58 | Inquiry |
| Aurazia Chem Laboratories Private Limited | +91-9840924287 +91-8754492844 | Tamil Nadu, India | 29 | 58 | Inquiry |
| LOBA CHEMIE PVT.LTD. | 91-22-6663 6699 | Mumbai, India | 3077 | 58 | Inquiry |
| Yogi Dye Chem Pvt Ltd. (Unit Of Forbes... | 08047637783 | Mumbai, India | 43 | 58 | Inquiry |
| Forbes Pharmaceuticals | 08048954143 | Mumbai, India | 59 | 58 | Inquiry |
| HiMedia Laboratories | 91-22-61471919 | Maharashtra, India | 1843 | 58 | Inquiry |
| Manus Aktteva Biopharma LLP | 08048250218Ext 800 | Ahmedabad, India | 655 | 58 | Inquiry |
| Kps Chemicals | 09423368779 | Maharashtra, India | 3 | 58 | Inquiry |
| Auraziachem Laboraotories Private Limited | 91-8754492844 | Tamil Nadu, India | 20 | 58 | Inquiry |
| Spectrochem Private Limited | 08048372608Ext 246 | Maharashtra, India | 1056 | 58 | Inquiry |