Phenyl dichlorophosphate
- CAS No.
- 770-12-7
- Chemical Name:
- Phenyl dichlorophosphate
- Synonyms
- PHENYL PHOSPHORODICHLORIDATE;MPCP;O-phenyl phosphorodichloridate;PCDP;orophosphate;Phenyl dichlorophosp;Picaridin Impurity 7;Phenyl dichlorophosphat;PHENYL DICHLOROPHOSPHATE;PHYENYL DICHLOVOPHOSPHATE
- CBNumber:
- CB1669062
- Molecular Formula:
- C6H5Cl2O2P
- Molecular Weight:
- 210.98
- MOL File:
- 770-12-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/31 17:33:32
| Melting point | -1 °C |
|---|---|
| Boiling point | 241-243 °C (lit.) |
| Density | 1.412 g/mL at 25 °C (lit.) |
| vapor pressure | 2.33Pa at 25℃ |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | 2-8°C |
| solubility | soluble in Chloroform |
| form | Liquid |
| color | Clear colorless to very slightly brown |
| Water Solubility | Decomposes |
| Sensitive | Moisture Sensitive |
| Merck | 14,7282 |
| BRN | 511863 |
| Stability | Moisture Sensitive |
| InChIKey | TXFOLHZMICYNRM-UHFFFAOYSA-N |
| CAS DataBase Reference | 770-12-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Phosphorodichloridic acid, phenyl ester(770-12-7) |
| EPA Substance Registry System | Phosphorodichloridic acid, phenyl ester (770-12-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405 | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34-37 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| RIDADR | UN 3265 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TD4393000 | |||||||||
| F | 10 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29209085 | |||||||||
| NFPA 704 |
|
Phenyl dichlorophosphate price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | P22389 | Phenyl dichlorophosphate ≥95% | 770-12-7 | 25G | ₹4416.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P22389 | Phenyl dichlorophosphate ≥95% | 770-12-7 | 100G | ₹9850.75 | 2022-06-14 | Buy |
| ALFA India | ALF-A10479-36 | Phenyl phosphorodichloridate, 97% | 770-12-7 | 500g | ₹20500 | 2022-05-26 | Buy |
| ALFA India | ALF-A10479-22 | Phenyl phosphorodichloridate, 97% | 770-12-7 | 100g | ₹6889 | 2022-05-26 | Buy |
| ALFA India | ALF-A10479-14 | Phenyl phosphorodichloridate, 97% | 770-12-7 | 25g | ₹2839 | 2022-05-26 | Buy |
Phenyl dichlorophosphate Chemical Properties,Uses,Production
Chemical Properties
clear colourless to very slightly brown liquid
Uses
Reagent for preparation of phosphate diesters. Phenyl dichlorophosphate is used in the preparation of symmetrical phosphate diesters. It is used as a phosphorylating agent for alcohols and amines. It is also involved in the preparation of phenylphosphoro di-(1-imidazolidate) and 2-phenyl-bis-triazoloylphosphate, which is used in peptide synthesis. It plays a vital role in the Pfitzner-Moffatt oxidation which involves oxidation of alcohols to the corresponding aldehydes and ketones. Furthermore, it is utilized in Beckmann rearrangement for the preparation of N-phenylacetamide from acetophenone oxime.
Uses
In organic synthesis for preparation of lactams, phosphate diesters and for oxidation reactions.
Preparation
The preparation of Phenyl dichlorophosphate is as follows:160 g (1 mol) of phosphorus oxychloride and 1 g of titanium tetrachloride were respectively added to a four-necked flask to carry out the reaction, and the temperature was raised to 70-80° C., and phenol (94 g, 1 mol) was slowly added dropwise. The phenol addition time was about 2- 3 hours,After completion of the dropwise addition, the reaction is maintained at 80-90° C. for 3-5 hours. After no hydrogen chloride is evolved, the reaction is completed. After the reaction, the phosphorus oxychloride is distilled under reduced pressure, the vacuum degree is 30-100 KPa, and the distillation temperature is 30-100° C. Distillation under reduced pressure to obtain the intermediate of the mixture, a mono-substituted and di-substituted mixture of phosphorus oxychloride, the ratio of the mixture is 5:5, gas phase analysis to obtain the intermediate of the mixture, the yield of the intermediate is 95%, phosphorus oxychloride The recovery rate is 95% (calculated as phosphorus oxychloride).
General Description
A liquid. May severely irritate skin, eyes and mucous membranes.
Air & Water Reactions
About the same density as water and moderately soluble in water.
Reactivity Profile
An hologenated organophosphate. Organophosphates are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.
Hazard
May cause severe skin, eye, and mucous membrane irritation; Reacts violently with water; Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; Toxic by ingestion; Highly toxic by skin absorption; Dermal LD50 (guinea pig) = 14-400 mg/kg.
Health Hazard
TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire Hazard
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.
Phenyl dichlorophosphate Preparation Products And Raw materials
Raw materials
Preparation Products
1of2
chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SYNOVA CHEMICALS | +91-9920741772 +91-9920741772 | Mumbai, India | 428 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| Adishank Chemicals Pvt Ltd | +91-9821112126 +91-9324787427 | Maharashtra, India | 7 | 58 | Inquiry |
| Otto Chemie Pvt Ltd | +91-2222070099 +91-2266382599 | Maharashtra, India | 429 | 58 | Inquiry |
| Horizon Chemicals | +undefined-9426020080 +undefined-9717770497 | Gujarat, India | 12 | 58 | Inquiry |
| Pharmaffiliates Analytics & Synthetics (P) Ltd. | 91-172-5066494 | Haryana, India | 631 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| SYNOVA CHEMICALS | 58 |
| JSK Chemicals | 58 |
| Adishank Chemicals Pvt Ltd | 58 |
| Otto Chemie Pvt Ltd | 58 |
| Horizon Chemicals | 58 |
| Pharmaffiliates Analytics & Synthetics (P) Ltd. | 58 |
| A.J Chemicals | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Alfa Aesar | 58 |
| Otto Chemie Pvt. Ltd. | 58 |