N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE

CAS No.: 127243-85-0

Chemical Name:: N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE

Synonyms: H-89;CS-2385;H-89 hcl;H89 DIHCL;H-89 free base;H-89 ＆ H-89 2HCl;H-89 HYDROCHLORIDE;H-89 DIHYDROCHLORIDE;H-89 dihydrochloride,98%;Protein kinase inhibitor H-89

CBNumber:: CB1853005

Molecular Formula:: C20H20BrN3O2S

Molecular Weight:: 446.36

MOL File:: 127243-85-0.mol

MSDS File:: SDS

Modify Date:: 2023/5/18 11:31:20

Request For Quotation

N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE Properties

Melting point	195-200°C
Boiling point	639.7±65.0 °C(Predicted)
Density	1.436
storage temp.	2-8°C
solubility	H₂O: ≥10 mg/mL
form	powder
pka	10.43±0.50(Predicted)
color	off-white
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
CAS DataBase Reference	127243-85-0(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H335-H315-H302-H312-H319-H332
Precautionary statements	P264-P270-P301+P312-P330-P501-P280-P302+P352-P312-P322-P363-P501-P264-P280-P305+P351+P338-P337+P313P-P261-P271-P304+P340-P312-P264-P280-P302+P352-P321-P332+P313-P362
Safety Statements	22-24/25
WGK Germany	3
HS Code	29350090

N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE Chemical Properties,Uses,Production

Chemical Properties

White Solid

Definition

ChEBI: A member of the class of isoquinolines that is the sulfonamide obtained by formal condensation of the sulfo group of isoquinoline-5-sulfonic acid with the primary amino group of N1-[3-(4-bromophenyl)prop-2-en-1-yl]et ane-1,2-diamine.

General Description

A cell-permeable, selective, reversible, ATP-competitive and potent inhibitor of protein kinase A (K_i = 48 nM). Inhibits other kinases at several fold higher concentrations: myosin light chain kinase (K_i = 28.3 μM), Ca²⁺/calmodulin-dependent protein kinase II (K_i = 29.7 μM), protein kinase C (K_i = 31.7 μM), casein kinase I (K_i = 38.3 μM), and Rho Kinase II (IC₅₀ = 270 nM). May be used to discriminate between the effects of PKA and cAMP-regulated guanine-nucleotide-exchange factors (GEFs), such as GEFI or Epac (exchange protein directly activated by cAMP) and GEFII. Reported to induce neurite formation in NG 108-15 cells (~1 mM) by blocking the action of Rho kinase II.

Biological Activity

Protein kinase A inhibitor that also inhibits several other kinases (IC 50 values are 80, 120, 135, 270, 2600 and 2800 nM for S6K1, MSK1, PKA, ROCKII, PKB α and MAPKAP-K1b).

N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE Suppliers

Global( 129)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49391	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29826	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
Finetech Industry Limited	+86-27-87465837 +8618971612321	China	9626	58	Inquiry
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	China	52861	58	Inquiry
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6393	58	Inquiry
Coresyn Pharmatech Co., Ltd.	+86-571-86626709 +86-18157142896	China	9991	58	Inquiry
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	China	3136	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
ATK CHEMICAL COMPANY LIMITED	60
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
Finetech Industry Limited	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
InvivoChem	58
Coresyn Pharmatech Co., Ltd.	58
Nantong HI-FUTURE Biology Co., Ltd.	58

127243-85-0(N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE)Related Search:

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Propylamine H-89 DIHYDROCHLORIDE HYDRATE N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE

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H-89 H-89 DIHYDROCHLORIDE H-89 HYDROCHLORIDE N-[2-(P-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE N-[2-(P-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE 2HCL N-[2-(P-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE, DIHYDROCHLORIDE N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE N-[2-[P-BROMOCINNAMYLAMINO]-ETHYL]-5-ISOQUINOLINESULFONMIDE H-89 dihydrochloride,98% H89 DIHCL N-[2-[[3-(4-Bromophenyl)-2-propenyl]amino]ethyl]-5-isoquinolinesulfonamidedihydrochloride H-89, Dihydrochloride Salt >99% N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinoline sulfonamide, Di-HCl Salt N-[2-[[3-(4-Bromophenyl)-2-propen-1-yl]amino]ethyl]-5-isoquinolinesulfonamide N-(2-((3-(4-BroMophenyl)allyl)aMino)ethyl)isoquinoline-5-sulfonaMide dihydrochloride 5-IsoquinolinesulfonaMide,N-[2-[[3-(4-broMophenyl)-2-propen-1-yl]aMino]ethyl]- Protein kinase inhibitor H-89 H-89 hcl H-89 ＆ H-89 2HCl N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide (E)-N-(2-((3-(4-bromophenyl)allyl)amino)ethyl)isoquinoline-5-sulfonamide H-89 dihydrochloride, 98%, a potent and selective inhibitor of PKA H 89 2HCl,H 89 dihydrochloride H-89, Dihydrochloride - CAS 127243-85-0 - Calbiochem CS-2385 H 89 (Protein kinase inhibitor H-89 N-[2-[3-(4-bromophenyl)prop-2-enylamino]ethyl]-5-isoquinolinesulfonamide dihydrochloride N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLI H-89 free base 127243-85-0 C20H22BrN3O2SCl2 C20H22BrCl2N3O2S C20H20BrN3O2S2HCl C20H20BrN3O2S C20H20BrN3O2S2ClH Kinase/Phosphatase Biology Protein Kinase A (PKA) Serine/Threonine Kinase Inhibitors BioChemical Cell Biology Cell Signaling and Neuroscience Inhibitor Protein Kinase Inhibitors and Activators