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tipepidine

tipepidine Structure
CAS No.
5169-78-8
Chemical Name:
tipepidine
Synonyms
Cr/662;At 327;Bitiodin;tipepidine;Brn 0212554;tipepidine USP/EP/BP;14698-07-8 (Citrate[1:1]);3-(Dithien-2-ylmethylene)-1-methylpiperidine;3-(Di-2-thienylmethylene)-1-methyl-piperidine;1-Methyl-3-piperidylidenedi(2-thienyl)methane
CBNumber:
CB1875368
Molecular Formula:
C15H17NS2
Molecular Weight:
275.43
MOL File:
5169-78-8.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:01

tipepidine Properties

Melting point 64-65°
Boiling point bp4-5 178-184°
Density 1.1947 (rough estimate)
refractive index 1.5300 (estimate)
pka 8.23±0.20(Predicted)
form Solid
color White to light yellow

SAFETY

Risk and Safety Statements

Toxicity LD50 in mice (mg/kg): 294 i.p.; 308 i.m.; 867 orally (Higaki)

tipepidine Chemical Properties,Uses,Production

Originator

Sotal,G. Ramon

Manufacturing Process

From ethyl 1-methylpiperidine-3-carboxylate (which was prepared by hydrogenation of ethyl nicotinate with Ni-catalyst and then by methylation by action dimethyl sulfate) and 2-thienyl magnesium bromide was synthesized 1,1-di(thiophen-2-yl)-2-(3'-N-methylpiperidine), 3-(di-2-thienylmethylene)-1- methylpiperidine was obtained by dehydration of 1,1-di(thiophen-2-yl)-2-(3'- N-methylpiperidine) by action of base.

Therapeutic Function

Antitussive, Expectorant

tipepidine Preparation Products And Raw materials

Raw materials

Preparation Products

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14698-07-8 (Citrate[1:1]) 1-Methyl-3-piperidylidenedi(2-thienyl)methane 3-(Di-2-thienylmethylene)-1-methyl-piperidine At 327 Bitiodin Brn 0212554 Cr/662 3-(Dithien-2-ylmethylene)-1-methylpiperidine 3-(dithiophen-2-ylmethylidene)-1-methylpiperidine tipepidine 3-( di-2-thienylmethylene)-1-methylpiperidine hydrochloride Piperidine, 3-(di-2-thienylmethylene)-1-methyl- tipepidine USP/EP/BP 5169-78-8 C15H17NS2