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SANT-1

SANT-1 Structure
CAS No.
304909-07-7
Chemical Name:
SANT-1
Synonyms
SANT-1;CS-1685;SANT1 10MG;SANT1;SANT 1;SANT-1 USP/EP/BP;SANT-1; SANT1;SANT 1;SANT-1 - CAS 304909-07-7 - Calbiochem;SANT-1 (This product is only available in Japan.);SANT1,Smoothened,Hedgehog,Inhibitor,Smo,SANT-1,inhibit;(E)-N-(4-benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenylpyrazol-4-yl)methanimine
CBNumber:
CB2141123
Molecular Formula:
C23H27N5
Molecular Weight:
373.49
MOL File:
304909-07-7.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:02
Request For Quotation

SANT-1 Properties

Melting point 104-106°C
Boiling point 547.4±50.0 °C(Predicted)
Density 1.13±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility Soluble in DMSO with warming
form White solid
pka 7.35±0.10(Predicted)
color White to off-white
Sensitive Moisture & Light Sensitive
CAS DataBase Reference 304909-07-7

SAFETY

Risk and Safety Statements

WGK Germany  3

SANT-1 price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) S4572 SANT-1 ≥98% (HPLC), powder 304909-07-7 5MG ₹17731.35 2022-06-14 Buy
Sigma-Aldrich(India) S4572 SANT-1 ≥98% (HPLC), powder 304909-07-7 25MG ₹78719.4 2022-06-14 Buy
Sigma-Aldrich(India) 559303 SANT-1 - CAS 304909-07-7 - Calbiochem A potent, cell-permeable antagonist of the Shh signaling pathway by binding directly to Smoothened, a distant relative of G protein-coupled receptors. 304909-07-7 5MG ₹20250 2022-06-14 Buy
Product number Packaging Price Buy
S4572 5MG ₹17731.35 Buy
S4572 25MG ₹78719.4 Buy
559303 5MG ₹20250 Buy

SANT-1 Chemical Properties,Uses,Production

Description

Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. SANT 1 is a potent inhibitor of hedgehog signaling that acts by directly antagonizing SMO (IC50 = 20 nM). It counteracts SMO activation by the SMO agonist SAG but only partially competes with SAG binding to SMO. SANT 1 targets inactive SMO while it is in the cytoplasm, before it relocates to the primary cilium and is activated. Through antagonism of SMO, SANT 1 represses Gli-mediated transcription in a variety of cell types.

Chemical Properties

Pale Yellow Solid

Uses

Treatment of Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma cells2 and chronic lymphocytic leukemia cells3 with SANT-1 induced cell death.

Biological Activity

Potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (K D = 1.2 nM). Inhibits smoothened agonist effects with an IC 50 of 20 nM (in Shh-LIGHT2 cells).

SANT-1 Preparation Products And Raw materials

Raw materials

Preparation Products

SANT-1 Suppliers

Global( 86)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 26216 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 China 11681 58 Inquiry
LEAPCHEM CO., LTD. +86-852-30606658 China 43348 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Supplier Advantage
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
ATK CHEMICAL COMPANY LIMITED 60
TargetMol Chemicals Inc. 58
Dideu Industries Group Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58
LEAPCHEM CO., LTD. 58
Aladdin Scientific 58

SANT-1 Spectrum

SANT-1(304909-07-7)1HNMR

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N-[(3,5-DIMETHYL-1-PHENYL-1H-PYRAZOL-4-YL)METHYLENE]-4-(PHENYLMETHYL)-1-PIPERAZINAMINE SANT-1 (4-Benzyl-piperazin-1-yl)-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-ylmethylene)-amine 1-Piperazinamine, N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)- (E)-N-(4-benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenylpyrazol-4-yl)methanimine SANT1 10MG SANT1;SANT 1 SANT-1 - CAS 304909-07-7 - Calbiochem CS-1685 SANT-1; SANT1;SANT 1 SANT-1 (This product is only available in Japan.) N-(4-Benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methanimine SANT-1 USP/EP/BP SANT1,Smoothened,Hedgehog,Inhibitor,Smo,SANT-1,inhibit 304909-07-7 C23H27N5 Lipid signaling Inhibitors All Inhibitors API