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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Stem Cells & Wnt >Hedgehog / Smoothened antagonist >SANT-1

SANT-1

SANT-1 Structure
  • ₹17731.35 - ₹78719.4
  • Product name: SANT-1
  • CAS: 304909-07-7
  • MF: C23H27N5
  • MW: 373.49
  • EINECS:
  • MDL Number:MFCD01827306
  • Synonyms:N-[(3,5-DIMETHYL-1-PHENYL-1H-PYRAZOL-4-YL)METHYLENE]-4-(PHENYLMETHYL)-1-PIPERAZINAMINE;SANT-1;(4-Benzyl-piperazin-1-yl)-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-ylmethylene)-amine;1-Piperazinamine, N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-;(E)-N-(4-benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenylpyrazol-4-yl)methanimine;SANT1 10MG;SANT1;SANT 1;SANT-1 - CAS 304909-07-7 - Calbiochem
Price3 Properties Safety Information Description
3 prices
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Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberS4572
  • Product descriptionSANT-1 ≥98% (HPLC), powder
  • Packaging5MG
  • Price₹17731.35
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number559303
  • Product descriptionSANT-1 - CAS 304909-07-7 - Calbiochem A potent, cell-permeable antagonist of the Shh signaling pathway by binding directly to Smoothened, a distant relative of G protein-coupled receptors.
  • Packaging5MG
  • Price₹20250
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberS4572
  • Product descriptionSANT-1 ≥98% (HPLC), powder
  • Packaging25MG
  • Price₹78719.4
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) S4572 SANT-1 ≥98% (HPLC), powder 5MG ₹17731.35 2022-06-14 Buy
Sigma-Aldrich(India) 559303 SANT-1 - CAS 304909-07-7 - Calbiochem A potent, cell-permeable antagonist of the Shh signaling pathway by binding directly to Smoothened, a distant relative of G protein-coupled receptors. 5MG ₹20250 2022-06-14 Buy
Sigma-Aldrich(India) S4572 SANT-1 ≥98% (HPLC), powder 25MG ₹78719.4 2022-06-14 Buy

Properties

Melting point :104-106°C
Boiling point :547.4±50.0 °C(Predicted)
Density :1.13±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO with warming
form :White solid
pka :7.35±0.10(Predicted)
color :White to off-white
Sensitive :Moisture & Light Sensitive
CAS DataBase Reference :304909-07-7

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. SANT 1 is a potent inhibitor of hedgehog signaling that acts by directly antagonizing SMO (IC50 = 20 nM). It counteracts SMO activation by the SMO agonist SAG but only partially competes with SAG binding to SMO. SANT 1 targets inactive SMO while it is in the cytoplasm, before it relocates to the primary cilium and is activated. Through antagonism of SMO, SANT 1 represses Gli-mediated transcription in a variety of cell types.

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