Uridine-5'-diphosphate disodium salt
- CAS No.
- 27821-45-0
- Chemical Name:
- Uridine-5'-diphosphate disodium salt
- Synonyms
- UDP 2NA;UDP.Na2;5′-UDP,2Na;5'-UDP-Na2;Einecs 248-678-9;5'-UDP 2Na Hydrate;Diquafosol Impurity 17;Uridine 5’-diphosphate;Sodium 1-((2R,3R,4S,5R);UDP(URIDINE-5''-DIPHOSPHATE)
- CBNumber:
- CB2143213
- Molecular Formula:
- C9H15N2NaO12P2
- Molecular Weight:
- 428.16
- MOL File:
- 27821-45-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/12 15:32:57
| storage temp. | -20°C |
|---|---|
| form | Powder |
| color | White to Off-white |
| Water Solubility | Slightly soluble in water. |
| Sensitive | Moisture Sensitive |
| BRN | 8817400 |
| InChIKey | KWDGQJWFEYTPBN-IBOJMDDDSA-L |
| SMILES | O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP(O)(O)=O)O[C@H]1N1C=CC(=O)NC1=O)O.[NaH] |&1:1,2,3,15,r| |
| CAS DataBase Reference | 27821-45-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| F | 10-21 |
| HS Code | 29349990 |
Uridine-5'-diphosphate disodium salt price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 94330 | Uridine 5′-diphosphate disodium salt hydrate ≥96.0% (HPLC) | 27821-45-0 | 100MG | ₹11615.23 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 94330 | Uridine 5′-diphosphate disodium salt hydrate ≥96.0% (HPLC) | 27821-45-0 | 500MG | ₹42585.55 | 2022-06-14 | Buy |
Uridine-5'-diphosphate disodium salt Chemical Properties,Uses,Production
Uses
Uridine-5'-diphosphate disodium salt (UDP-Na2) is an organometallic compound, It is a P2Y6 receptor agonist and GPR105 receptor inhibitor. It is used in studies on nucleic acid (RNA) biosynthesis and cell signaling. UDP is a nucleotide that upon phosphorylation to UTP becomes a substrate for enzymes such as RNA polymerase(s) and GTPases. These enzymes are involved in a wide range of applications from the synthesis of RNA to the regulation of G-coupled Protein Receptors (GPCR) and cell signaling molecules such as Rho-signaling via Guanine Nucleotide Exchange Factors (GEF).
Application
Uridine 5′-diphosphate disodium salt hydrate has been used:
as a standard for quantification of metabolite levels in murine tumor interstitial fluid by liquid chromatography-mass spectrometry (LC/MS)
as a UDP standard for nucleotide analysis by liquid chromatography-high resolution mass spectrometry (LC-HRMS)
to treat E6.5 retina explants in vitro, to study its effect on the entry and elongation of microglial cells into the embryonic quail retina
Purification Methods
Crystallise it from MeOH. It may contain some Ba salt(s); hence stir it with Amberlite IR-120 cation exchanger (25mL, wet resin, 15-50 mesh in H+ form) in H2O (50mL) until the nucleotide dissolves. Filter, wash resin with H2O until the eluate is neutral. Combine the filtrate and washings, and adjust the pH to 8.0 with 2.0 M aqueous NaOH. Concentrate it in vacuo to a small volume (~ 20mL), and add Me2CO dropwise until crystallisation begins. Cool to 0o, and the shiny plates of di Na uridine-5’-phosphate dihydrate are filtered off and dried over P2O5 at 25o/0.1mm for 24hours (>76% recovery). UV: max at 262nm ( 10,000 M-1cm -1) in 0.1 M HCl. [Boon et al. J Chem Soc 408 1950, Smith Biochemical Preparations 8 130 1960.] [Beilstein 24 IV 1214.]
Uridine-5'-diphosphate disodium salt Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CD Chemical Group Limited | +8615986615575 | China | 20356 | 58 | Inquiry |
| Hangzhou Weitai Biological Pharmaceutical Co.,Ltd. | +8613282012786 | China | 61 | 58 | Inquiry |
| HangZhou RunYan Pharma Technology Co.,LTD. | +86-88660901 +86-18112526015 | China | 326 | 58 | Inquiry |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | China | 10978 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81148696 +8615536356810 | China | 1418 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12460 | 58 | Inquiry |
| Hebei Duling International Trade Co. LTD | +8617333973358 | China | 15437 | 58 | Inquiry |
| Hangzhou Meiya Pharmaceutical Co Ltd | +86-021-33686691 +8618001850931 | China | 58 | 58 | Inquiry |