Capecitabine
- CAS No.
- 158798-73-3
- Chemical Name:
- Capecitabine
- Synonyms
- Caxeta;Capiibine;Hsdb 7656;N(4)-Pentyloxycarbonyl-5'-deoxy-5-fluorocytidine;pentyl N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoro-2-oxopyrimidin-4-yl]carbamate;Pentyl N-[1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-methyl-oxolan-2-yl]-5-fluoro-2-oxo-pyrimidin-4-yl]carbamate;Carbamic acid, (1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-, pentyl ester
- CBNumber:
- CB21503999
- Molecular Formula:
- C15H22FN3O6
- Molecular Weight:
- 359.35
- MOL File:
- 158798-73-3.mol
Capecitabine Chemical Properties,Uses,Production
Originator
Xeloda,Hoffmann - La Roche Inc.,USA
Manufacturing Process
5-Deoxy-5-fluoro-N4-((n-pentyloxy)carbonyl)cytidine may be prepared
according to US Patent No. 6,114,520.
From 2',3'-bis-O-(tert-butyldimethylsilyl)-5'-deoxy-5-fluorocytidine and n-pentylchloroformate in dichloromethane and pyridine may be obtained 2',3'-
bis-O-(tert-butyldimethylsilyl)-5'-deoxy-5-fluoro-N4-((pentyloxy)carbonyl)
cytidine.From 2',3'-bis-O-(tert-butyldimethylsilyl)-5'-deoxy-5-fluoro-N4-
((pentyloxy)carbonyl)cytidineand tetrabutylammonium fluoride in
tetrahydrofuran at room temperature for 2 hours may be prepared the
product which by hydrolyses may be converted to 5-deoxy-5-fluoro-N4-
((pentyloxy)carbonyl)cytidine. Purification of the product may be carried out
by silica gel chromatography (using dichloromethane:methanol = 20:1 as an
eluent).
Therapeutic Function
Antitumor
Capecitabine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | China | 23556 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 26368 | 58 | Inquiry |
| NewCan Biotech Limited | +86-0571-86912261 +8613735419629 | China | 9980 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | China | 25363 | 58 | Inquiry |
| Suzhou Daolan Biomedical Technology Co., Ltd. | 13771737464 | China | 2810 | 58 | Inquiry |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | China | 8018 | 62 | Inquiry |
| CarboMer, Inc. | 858 552 0992 | United States | 4027 | 67 | Inquiry |
| Raw material medicin reagent co.,Ltd | China | 4534 | 58 | Inquiry | |
| Nanjing Sunlida Biological Technology Co., Ltd. | 025-57798810 | China | 3750 | 55 | Inquiry |
| Twochem Co.Ltd. | 021-58111628 15800915896 | China | 1841 | 58 | Inquiry |