Zoledronate disodium tetrahydrate
- CAS No.
- 165800-07-7
- Chemical Name:
- Zoledronate disodium tetrahydrate
- Synonyms
- CGP-42446A;Disodium salt tetrahydrate;Zoledronate Disodium, CGP-42446A;ZOLEDRONATE DISODIUM, TETRAHYDRATE;Zoledronic acid disodium tetrahydrate;Zoledronate DisodiuM (C5H8N2Na2O7P24H2O);ZOLEDRONIC ACID, DISODIUM SALT, TETRAHYDRATE;Zoledronate disodium salt, bisphosphonate bone resorption inhibitor;Sodium (1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl)phosphonate tetrahydrate;(1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene)bisphosphonic acid disodium salt tetrahydrate
- CBNumber:
- CB2191764
- Molecular Formula:
- C5H13N2NaO8P2
- Molecular Weight:
- 314.1
- MOL File:
- 165800-07-7.mol
- Modify Date:
- 2024/10/28 23:16:16
Zoledronate disodium tetrahydrate Chemical Properties,Uses,Production
Description
Zoledronate was introduced in Canada as a lyophilized powder in vials for infusion as solution in the treatment of tumor-induced hypercalcemia. This third-generation bisphosphonate can be obtained by reaction of 2-(1-imidazolyl)acetic acid hydrochloride with phosphorous trichloride followed by hydrolysis in concentrated hydrochloric acid, Zoledronate originated from a medicinal chemistry program started at Novartis, Switzerland in 1986 and aimed at discovering a follow-up to pamidronate for the treatment of osteoporosis and metastatic bone disease. It has highly potent inhibitory effect on hypercalcemia induced by vitamin Ds both in vitro in mouse calvarial cultures and in viva in the thyroparathyroidectomized rat. It is respectively 100 and 850-fold more potent than pamidronate in the former and latter tests. Clinically, it was demonstrated that zoledronate achieved normalized serum calcium concentrations in a significantly higher percentage of cancer patients compared to pamidronate. The 5 minute infusion with zoledronate was more convenient than the 2 hour infusion necessary with pamidronate.
Chemical Properties
White Crystalline Powder
Uses
A biphosphonate bone resorption inhibitor.
Zoledronate disodium tetrahydrate Preparation Products And Raw materials
Raw materials
Preparation Products
Zoledronate disodium tetrahydrate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
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| TargetMol Chemicals Inc. | +8613564774135 | United States | 19881 | 58 | Inquiry |
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| Chengdu Peter-like Biotechnology Co., Ltd. | 028-81700200 13308200041 | China | 11183 | 58 | Inquiry |
| Abcam | +1 (877) 774-8286 | United States | 6001 | 50 | Inquiry |
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