ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >TGF-beta / Smad >TGF-beta / Smad inhibitors >LDN-193189

LDN-193189

CAS No.: 1062368-24-4

Chemical Name:: LDN-193189

Synonyms: LDN193189;CS-205;DM-3189;DM 3189;LDN193189(DM3189);LDN-193189, >=98%;LDN193189 free base;LDN-193189;LDN 193189;LDN193189 LDN193189 HCl;LDN-193189;LDN 193189;DM-3189;DM 3189

CBNumber:: CB22512071

Molecular Formula:: C25H22N6

Molecular Weight:: 406.48

MOL File:: 1062368-24-4.mol

MSDS File:: SDS

Modify Date:: 2023/5/18 11:31:16

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LDN-193189 Properties

Density	1.33
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	H2O: soluble5mg/mL, clear (warmed)
form	powder
pka	8.79±0.10(Predicted)
color	yellow to orange
InChIKey	XHBVYDAKJHETMP-UHFFFAOYSA-N

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
WGK Germany	3
HS Code	29339900

LDN-193189 price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	SML0559	LDN193189 hydrochloride ≥98% (HPLC)	1062368-24-4	5MG	₹12609.6	2022-06-14	Buy
Sigma-Aldrich(India)	SML0559	LDN193189 hydrochloride ≥98% (HPLC)	1062368-24-4	25MG	₹50849.1	2022-06-14	Buy

Product number	Packaging	Price	Buy
SML0559	5MG	₹12609.6	Buy
SML0559	25MG	₹50849.1	Buy

LDN-193189 Chemical Properties,Uses,Production

Description

Normal development and tissue repair are controlled in part by SMADs, a family of intracellular proteins that are activated by signaling via serine/threonine kinase receptors of the TGF-β superfamily. LDN-193189 inhibits SMAD1/5/8 phosphorylation by the bone morphogenetic protein (BMP) type I receptors, which are known as activin receptor-like kinases (ALKs), with an IC₅₀ value of 4.9 nM. In in vitro kinase assays, it shows specificity for ALK1, 2, 3, and 6 (IC₅₀s = 0.8, 0.8, 5.3, and 16.7 nM, respectively) over ALK4 and 5 (IC₅₀s = 101 and 350 nM, respectively). LDN-193189 has been used to inhibit BMP type I receptor activity to study the pathogenesis of fibrodysplasia ossificans progressive, a congenital hyperossification disorder, and to examine the role of osteogenesis in prostate tumor metastases in bone.

Uses

4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline, is a selective inhibitor of bone morphogenetic protein (BMP) pathway, useful in the treatment of diseases. Potent BMP Inhibitor?, Promotes hPSC Neural Induction?.

Biochem/physiol Actions

Although LDN193189 is a structural analog of dorsomorphin, these two drugs are found to establish different cellular responses. In vitro analysis reveals that LDN193189 inhibits a number of intracellular kinases such as, mitogen activated protein kinase 14 and 8 ( p38and c-Jun N-terminal kinase respectively), as well as those associated with AKT (serine/threonine kinase) and mTOR (mammalian target of rapamycin) signaling mechanisms. LDN193189 is known to elevate the levels hemoglobin and thus helps to prevent the onset of anemia of inflammation.

LDN-193189 Preparation Products And Raw materials

Raw materials

4-(quinolin-4-yl)-1H-pyrazol-5-aMine 4-quinolylmethanol 4-Chloromethylquinoline 2-(quinolin-4-yl)acetonitrile 4-Quinolinecarboxaldehyde

Preparation Products

LDN-193189 Suppliers

Global( 161)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	China	29798	60	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49391	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29826	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	25247	58	Inquiry
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	China	10522	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
BOC Sciences	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58

LDN-193189 Spectrum

LDN-193189(1062368-24-4)¹HNMR

1062368-24-4(LDN-193189)Related Search:

LDN-212320 LDN-193189 HCl 2,5-Dimethoxyaniline tert-Butyl 1-piperazinecarboxylate Piperazine

LDN-214117 Y27632 (hydrochloride) 1,9-Pyrazoloanthrone SB 431542 LY2109761

ICG-001 LDN212854 Ldn193189

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LDN193189 LDN193189 HCl 4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline LDN193189(DM3189) 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline DM 3189 DM-3189 6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyriMidine LDN 193189(DM3189) 4-{6-[4-(piperazin-1-yl)phenyl]pyrazolo[ 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline LDN 193189 LDN 193189 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline hydrochloride LDN-193189, >=98% 6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine USP/EP/BP Quinoline, 4-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]- LDN-193189, 98%, a selective BMP signaling inhibitor LDN193189 free base CS-205 LDN-193189;LDN 193189 LDN-193189;LDN 193189;DM-3189;DM 3189 LDN193189 1062368-24-4 C25H22N6 Smad TGF-beta Inhibitors TGF-beta/Smad