LDN-193189
- ₹12609.6 - ₹50849.1
- Product name: LDN-193189
- CAS: 1062368-24-4
- MF: C25H22N6
- MW: 406.48
- EINECS:
- MDL Number:MFCD17169988
- Synonyms:LDN193189 LDN193189 HCl;4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline;LDN-193189;LDN 193189;DM-3189;DM 3189;LDN-193189;LDN 193189;CS-205;LDN193189 free base;LDN193189(DM3189);LDN193189
2 prices
Selected condition:
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML0559
- Product descriptionLDN193189 hydrochloride ≥98% (HPLC)
- Packaging5MG
- Price₹12609.6
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML0559
- Product descriptionLDN193189 hydrochloride ≥98% (HPLC)
- Packaging25MG
- Price₹50849.1
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | SML0559 | LDN193189 hydrochloride ≥98% (HPLC) | 5MG | ₹12609.6 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | SML0559 | LDN193189 hydrochloride ≥98% (HPLC) | 25MG | ₹50849.1 | 2022-06-14 | Buy |
Properties
Density :1.33
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :H2O: soluble5mg/mL, clear (warmed)
form :powder
pka :8.79±0.10(Predicted)
color :yellow to orange
InChIKey :XHBVYDAKJHETMP-UHFFFAOYSA-N
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :H2O: soluble5mg/mL, clear (warmed)
form :powder
pka :8.79±0.10(Predicted)
color :yellow to orange
InChIKey :XHBVYDAKJHETMP-UHFFFAOYSA-N
Safety Information
Symbol(GHS): | ||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Signal word: | Warning | |||||||||||||||||||||||||||||||||||
Hazard statements: |
|
|||||||||||||||||||||||||||||||||||
Precautionary statements: |
|
Description
Normal development and tissue repair are controlled in part by SMADs, a family of intracellular proteins that are activated by signaling via serine/threonine kinase receptors of the TGF-β superfamily. LDN-193189 inhibits SMAD1/5/8 phosphorylation by the bone morphogenetic protein (BMP) type I receptors, which are known as activin receptor-like kinases (ALKs), with an IC50 value of 4.9 nM. In in vitro kinase assays, it shows specificity for ALK1, 2, 3, and 6 (IC50s = 0.8, 0.8, 5.3, and 16.7 nM, respectively) over ALK4 and 5 (IC50s = 101 and 350 nM, respectively). LDN-193189 has been used to inhibit BMP type I receptor activity to study the pathogenesis of fibrodysplasia ossificans progressive, a congenital hyperossification disorder, and to examine the role of osteogenesis in prostate tumor metastases in bone.Related product price
- LDN212854
₹17815.5-71606.1 - SB 431542
₹7400-17947.85 - 1,9-Pyrazoloanthrone
₹6100-60295.25
Suppliers and manufacturers
career henan chemical co
CLEARSYNTH LABS LTD.
A.J Chemicals
Capot Chemical Co.,Ltd.
ATK CHEMICAL COMPANY LIMITED
BOC Sciences
CONIER CHEM AND PHARMA LIMITED
TargetMol Chemicals Inc.
Dideu Industries Group Limited
Zhejiang J&C Biological Technology Co.,Limited
₹9.80 /1.79999995231628KG
6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine CAS:1062368-24-4
6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine CAS:1062368-24-4