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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >TGF-beta / Smad >TGF-beta / Smad inhibitors >LDN-193189 HCl

LDN-193189 HCl

LDN-193189 HCl Structure
  • ₹0
  • Product name: LDN-193189 HCl
  • CAS: 1062368-62-0
  • MF: C25H23ClN6
  • MW: 442.94332
  • EINECS:
  • MDL Number:MFCD17392570
  • Synonyms:4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline hydrochloride;4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyriMidin-3-yl)quinoline HCl;LDN193189 (Hydrochloride);4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline hydrochloride (1:1);LDN-193189 HCl;LDN-193189 4HCl;LDN-193189 HCl USP/EP/BP;CS-1451
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :>240°C (dec.)
storage temp. :Inert atmosphere,Store in freezer, under -20°C
solubility :Methanol (Slightly), DMSO (Very Slightly, Heated)
form :Solid
color :Dark Orange
CAS DataBase Reference :1062368-62-0

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

LDN-193189 inhibits SMAD1/5/8 phosphorylation by the bone morphogenetic protein (BMP) type I receptors, which are known as activin receptor-like kinases (ALKs), with an IC50 value of 4.9 nM. In in vitro kinase assays, it shows specificity for ALK1, 2, 3, and 6 (IC50s = 0.8, 0.8, 5.3, and 16.7 nM, respectively) over ALK4 and 5 (IC50s = 101 and 350 nM, respectively). LDN-193189 has been used to inhibit BMP type I receptor activity to study the pathogenesis of fibrodysplasia ossificans progressive, a congenital hyperossification disorder, and to examine the role of osteogenesis in prostate tumor metastases in bone.

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Suppliers and manufacturers

career henan chemical co
LDN-193189 HCl
₹1.00 /1g
LDN-193189 HCl CAS:1062368-62-0
A.J Chemicals
ATK CHEMICAL COMPANY LIMITED
BOC Sciences
Dideu Industries Group Limited
InvivoChem
Nantong HI-FUTURE Biology Co., Ltd.
TargetMol Chemicals Inc.
ShenZhen Trendseen Biological Technology Co.,Ltd.
Shanghai Acmec Biochemical Technology Co., Ltd.