LDN-193189
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- ₹12609.6 - ₹50849.1
- Product name: LDN-193189
- CAS: 1062368-24-4
- MF: C25H22N6
- MW: 406.48
- EINECS:
- MDL Number:MFCD17169988
- Synonyms:LDN193189 LDN193189 HCl;4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline;LDN193189(DM3189);4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline;DM 3189;DM-3189;6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyriMidine LDN 193189(DM3189);4-{6-[4-(piperazin-1-yl)phenyl]pyrazolo[
2 prices
Selected condition:
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML0559
- Product descriptionLDN193189 hydrochloride ≥98% (HPLC)
- Packaging5MG
- Price₹12609.6
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML0559
- Product descriptionLDN193189 hydrochloride ≥98% (HPLC)
- Packaging25MG
- Price₹50849.1
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | SML0559 | LDN193189 hydrochloride ≥98% (HPLC) | 5MG | ₹12609.6 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | SML0559 | LDN193189 hydrochloride ≥98% (HPLC) | 25MG | ₹50849.1 | 2022-06-14 | Buy |
Properties
Density :1.33
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :H2O: soluble5mg/mL, clear (warmed)
form :powder
pka :8.79±0.10(Predicted)
color :yellow to orange
InChIKey :XHBVYDAKJHETMP-UHFFFAOYSA-N
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :H2O: soluble5mg/mL, clear (warmed)
form :powder
pka :8.79±0.10(Predicted)
color :yellow to orange
InChIKey :XHBVYDAKJHETMP-UHFFFAOYSA-N
Safety Information
Symbol(GHS): |
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Precautionary statements: |
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Description
Normal development and tissue repair are controlled in part by SMADs, a family of intracellular proteins that are activated by signaling via serine/threonine kinase receptors of the TGF-β superfamily. LDN-193189 inhibits SMAD1/5/8 phosphorylation by the bone morphogenetic protein (BMP) type I receptors, which are known as activin receptor-like kinases (ALKs), with an IC50 value of 4.9 nM. In in vitro kinase assays, it shows specificity for ALK1, 2, 3, and 6 (IC50s = 0.8, 0.8, 5.3, and 16.7 nM, respectively) over ALK4 and 5 (IC50s = 101 and 350 nM, respectively). LDN-193189 has been used to inhibit BMP type I receptor activity to study the pathogenesis of fibrodysplasia ossificans progressive, a congenital hyperossification disorder, and to examine the role of osteogenesis in prostate tumor metastases in bone.Related product price
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₹9.80 /1.79999995231628KG
6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine CAS:1062368-24-4
6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine CAS:1062368-24-4