METHACHOLINE CHLORIDE
- CAS No.
- 62-51-1
- Chemical Name:
- METHACHOLINE CHLORIDE
- Synonyms
- amechol;mecholyl;Methacloline;MECHOLYL CHLORIDE;Mecholine chloride;methylacetylcholine;Methacoline chloride;METHACHOLINE CHLORIDE;methacholiniumchloride;MethacholineChloride>
- CBNumber:
- CB2316248
- Molecular Formula:
- C8H18ClNO2
- Molecular Weight:
- 195.69
- MOL File:
- 62-51-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/9/4 16:42:00
| Melting point | 171-173 °C(lit.) |
|---|---|
| Density | 1.1028 (rough estimate) |
| refractive index | 1.5790 (estimate) |
| storage temp. | -20°C |
| solubility | H2O: 50 mg/mL, clear, colorless |
| form | powder |
| color | White to Almost white |
| PH | 3.0～7.0 (50g/l, 25℃) |
| Water Solubility | almost transparency |
| Merck | 14,5940 |
| BRN | 4162373 |
| Stability | Unstable - moisture sensitive. Incompatible with oxidizing agents. |
| LogP | -3.957 (est) |
| CAS DataBase Reference | 62-51-1 |
| EPA Substance Registry System | 1-Propanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, chloride (62-51-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P301+P312+P330-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | BR5250000 | |||||||||
| F | 3-10-21 | |||||||||
| HS Code | 29239000 | |||||||||
| NFPA 704 |
|
METHACHOLINE CHLORIDE price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | A2251 | Acetyl-β-methylcholine chloride ≥98% (TLC), powder | 62-51-1 | 25G | ₹14711.18 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1943 | Methacholine Chloride Pharmaceutical Secondary Standard; Certified Reference Material | 62-51-1 | 1G | ₹15826.15 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A2251 | Acetyl-β-methylcholine chloride ≥98% (TLC), powder | 62-51-1 | 100G | ₹29444 | 2022-06-14 | Buy |
| TCI Chemicals (India) | M0073 | Methacholine Chloride | 62-51-1 | 25G | ₹6500 | 2022-05-26 | Buy |
| TCI Chemicals (India) | M0073 | Methacholine Chloride | 62-51-1 | 100G | ₹10800 | 2022-05-26 | Buy |
METHACHOLINE CHLORIDE Chemical Properties,Uses,Production
Chemical Properties
colourless to white crystalline powder with a slight
Uses
antihypertensive, antianginal
General Description
Methacholine chloride occurs as colorless or white crystalsor as a white crystalline powder. It is odorless or has aslight odor and is very deliquescent. It is freely soluble inwater, alcohol, or chloroform, and its aqueous solution isneutral to litmus and bitter. It is hydrolyzed rapidly in alkalinesolutions. Solutions are relatively stable to heat and willkeep for at least 2 or 3 weeks when refrigerated to delaygrowth of molds.
Clinical Use
Methacholine, acetyl β-methylcholine, is marketed as the racemic mixture. It is a selective muscarinic agonist with very little activity at nicotinic receptors. Although methacholine chloride is marketed as the racemic mixture, the S-(+)-enantiomer is 240-fold more potent than the R-(–)-isomer at muscarinic receptors. In addition, AChE hydrolyzes S-(+)–methacholine at approximately 54% the rate of acetylcholine, whereas the R-(–)–enantiomer is a weak inhibitor. Methacholine chloride is used via inhalation for the diagnosis of asthma. The resulting bronchospasm may be relieved with bronchodilators. Methacholine chloride is available as a powder that is reconstituted for inhalation.
Purification Methods
It forms white hygroscopic needles from Et2O and is soluble in H2O, EtOH and CHCl3. It decomposes readily in alkaline solutions and slowly in H2O. It should be handled and stored in a dry atmosphere. The bromide is less hygroscopic, and the picrate has m 129.5-131o (from EtOH). [racemate: Annis & Ely Biochem J 53 34 1953, IR of iodide: Hansen Acta Chem Scand 13 155 1959, Beilstein 4 IV 1670.]
METHACHOLINE CHLORIDE Preparation Products And Raw materials
Raw materials
1of2
chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Sign Pharma Trade Services Pvt., Ltd.(SPTS) | 91-22-23481235 | Mumbai, India | 160 | 58 | Inquiry |
| GANGWAL CHEMICALS PVT LTD | +91 22 28889000 | New Delhi, India | 75 | 58 | Inquiry |
| Manus Aktteva Biopharma LLP | 08048250218Ext 800 | Ahmedabad, India | 655 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24330 | 58 | Inquiry |
| Alfa Chemistry | United States | 2344 | 58 | Inquiry |
62-51-1(METHACHOLINE CHLORIDE)Related Search:
1of4
chevron_right