Diosmetin
- CAS No.
- 520-34-3
- Chemical Name:
- Diosmetin
- Synonyms
- Diosmetine;Diosmetin (1.0 mg/mL in Methanol);5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone;Pillon;iosmetin;DIOSMETIN;Diosmetol;DIOSMETIN(P);Xiangye Lignin;Diosmetin, 97%+
- CBNumber:
- CB2380858
- Molecular Formula:
- C16H12O6
- Molecular Weight:
- 300.26
- MOL File:
- 520-34-3.mol
- Modify Date:
- 2024/7/2 8:55:03
| Melting point | 256-258°C |
|---|---|
| Boiling point | 576.7±50.0 °C(Predicted) |
| Density | 1.512±0.06 g/cm3(Predicted) |
| vapor pressure | 0Pa at 20℃ |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Soluble in acetonitrile, DMSO (60 mg/ml), and ethanol (17 mg/ml), clear, light yellow to yellow. |
| form | Solid |
| pka | 6.50±0.40(Predicted) |
| color | light yellow to yellow |
| Water Solubility | 19μg/L at 20℃ |
| BRN | 294492 |
| Stability | Hygroscopic |
| InChIKey | MBNGWHIJMBWFHU-UHFFFAOYSA-N |
| LogP | 3.1 at 20℃ |
| CAS DataBase Reference | 520-34-3(CAS DataBase Reference) |
Diosmetin price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | D7321 | Diosmetin | 520-34-3 | 10MG | ₹7707.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D7321 | Diosmetin | 520-34-3 | 100MG | ₹23338.7 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D7321 | Diosmetin | 520-34-3 | 500MG | ₹43657.23 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 90985 | Diosmetin analytical standard | 520-34-3 | 10MG | ₹22353.63 | 2022-06-14 | Buy |
| ottokemi | D 2228 | Diosmetin+ 97% | 520-34-3 | 10mg | ₹8019 | 2022-05-26 | Buy |
Diosmetin Chemical Properties,Uses,Production
Chemical Properties
Diosmetin is a flavonoid compound that appears as a yellow powder. It is extracted from lemon and also found in various other natural plants, including spearmint and spider incense. Diosmetin is slightly soluble in methanol but readily dissolves in DMSO.
Uses
Diosmetin (Diosmin EP Impurity F) is a metabolite of Apigenin. It exhibits anticancer, antimicrobial, antioxidant, oestrogenic, and anti-inflamatory activities. Diosmetin can be used in the production of functional foods, cosmetics, and future drugs with antioxidant, anti-infective and anti-shock effects.
Definition
ChEBI: Diosmetin is a monomethoxyflavone that is the 4'-methyl ether derivative of luteolin. It is a natural product isolated from citrus fruits which exhibits a range of pharmacological activities. It has a role as an antioxidant, an antineoplastic agent, a plant metabolite, a tropomyosin-related kinase B receptor agonist, an apoptosis inducer, an angiogenesis inhibitor, a cardioprotective agent, a bone density conservation agent, an anti-inflammatory agent and a vasodilator agent. It is a monomethoxyflavone, a trihydroxyflavone and a 3'-hydroxyflavonoid. It is functionally related to a luteolin. It is a conjugate acid of a diosmetin-7-olate.
References
[1]. ciolino hp, wang tt and yeh gc. diosmin and diosmetin are agonists of the aryl hydrocarbon receptor that differentially affect cytochrome p450 1a1 activity. cancer res, 1998, 58(13):2754-60. PMID: 9661887
[2]. gonzalez fj and fernandez-salguero p. the aryl hydrocarbon rreceptor studies using the ahr-null mice. drug metabolism and disposition, 1998, 26(12): 1194-1198. PMID: 9860927
[3]. and routsopoulos vp and spandidos da. The flavonoids diosmetin and luteolin exert synergistic cytostatic effects in human hepatoma HepG2 cells via CYP1A-catalyzed metabolism, activation of JNK and ERK and P53/P21 up-regulation. j nutr biochem, 2013, 24(2):496-504. DOI:10.1016/j.jnutbio.2012.01.012
Diosmetin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Anant Pharmaceuticals Pvt. ltd | +91 8550986868 | Maharashtra, India | 736 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Changsha Staherb Natural Ingredients Co., Ltd. | +86-0731-84213302 +86-18374838656 | China | 1025 | 58 | Inquiry |
| Hebei baicao biology science and technology co., ltd | +86-19131911055 +8617824879454 | China | 1035 | 58 | Inquiry |
| Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 | China | 2989 | 58 | Inquiry |
| BINBO BIOLOGICAL CO.,LTD | +8618629063126 | China | 346 | 58 | Inquiry |
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