Sesamol
- CAS No.
- 533-31-3
- Chemical Name:
- Sesamol
- Synonyms
- benzo[d][1,3]dioxol-5-ol;SesaMe phenol;1,3-BENZODIOXOL-5-OL;5-BENZODIOXOLOL;3,4-METHYLENEDIOXYPHENOL;SESAMOL;Sesamolr;NSC 59256;S**Sesamol;Sesamol>
- CBNumber:
- CB2413594
- Molecular Formula:
- C7H6O3
- Molecular Weight:
- 138.12
- MOL File:
- 533-31-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/21 22:41:43
| Melting point | 62-65 °C (lit.) |
|---|---|
| Boiling point | 113-116°C 2mm |
| Density | 1.2112 (rough estimate) |
| refractive index | 1.4850 (estimate) |
| Flash point | 113-116°C/2mm |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Chloroform, Methanol |
| form | crystalline |
| pka | 10.08±0.20(Predicted) |
| color | off-white to tan |
| Water Solubility | slightly soluble |
| Sensitive | Light Sensitive |
| BRN | 127405 |
| InChIKey | LUSZGTFNYDARNI-UHFFFAOYSA-N |
| LogP | 1.253 (est) |
| CAS DataBase Reference | 533-31-3(CAS DataBase Reference) |
| NIST Chemistry Reference | 1,3-Benzodioxol-5-ol(533-31-3) |
| EPA Substance Registry System | Sesamol (533-31-3) |
Sesamol price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | S3003 | Sesamol 98% | 533-31-3 | 5G | ₹2002.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | S3003 | Sesamol 98% | 533-31-3 | 25G | ₹5802.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 41557 | Sesamol analytical standard | 533-31-3 | 100MG | ₹6603.25 | 2022-06-14 | Buy |
| ALFA India | ALF-A10453-30 | Sesamol, 98% | 533-31-3 | 250g | ₹25929 | 2022-05-26 | Buy |
| ALFA India | ALF-A10453-18 | Sesamol, 98% | 533-31-3 | 50g | ₹9464 | 2022-05-26 | Buy |
Sesamol Chemical Properties,Uses,Production
Chemical Properties
off-white to beige crystalline powder
benefits
Sesamol, 5-hydroxy-1,3-benzodioxole or 3,4-methylene-dioxyphenol, is a water-soluble phenolic lignan isolated from roasted sesame seeds and processed sesame oil. Various studies investigated the anti-cancer therapeutic potential of sesamol, and the literature provided reveals compelling evidence that sesamol acts as a metabolic regulator and possesses antioxidant, anti-mutagenic, anti-hepatotoxic, anti-inflammatory, anti-aging, and chemopreventive properties.
General Description
Sesamol, a principal phytophenol of sesame oil lignans, is typically used as a dietary compound.(10)
Biological Activity
Sesamol has a wide range of biological actions including inhibition of lipid peroxidation and enhancement of radical scavenging, upregulation of antioxidant enzymes, suppression of TNFα 80 and IL-1β expression, inhibition of NF-κB 81 signaling, suppression of LOX-1 82 and 5-LOX activity, induction of 83 apoptosis, arresting cell growth at different phases of the cell cycle; and modulation of caspase-3, p53, Bax, and Bcl2 expression[3].
Pharmacokinetics
Sesamol (100 mg/kg body weight in rats) is reportedly eliminated from the body within 0-4 hours of oral administration as conjugates. The maximum plasma concentration (Cmax), half-life (t1/2), and area under the curve (AUC) of sesamol were found to be 1.4±0.7 μg/mL, 563.7±36.9 min, and 501.3±200.8 min μg/mL, respectively, following oral administration of 50 mg/kg body weight dose of sesamol to rats. A rapid decline in plasma concentrations and an oral bioavailability (BA) of 35.5 ± 8.5% has been reported for sesamol in Sprague Dawley rats. Sesamol is reported to undergo reductive cleavage to 2-methoxybenzene-1,4-diol and benzene-1,2,4-triol. Small quantities of these metabolites are observed in the urine of rats fed with sesamol. Moreover, sesamol or its metabolite was not detected when sesamol was incubated in vitro with rat faecal microbiota. Sesamol is excreted unchanged in the excreta, while it is a glucuronide in the urine. It is indicated that sesamol and its conjugated metabolites are rapidly eliminated from urine and feces in 0–4 h[4].
Solubility in water
Sesamol shows solubility of ~10 mg/mL (9.50-11.08 mg/ml) at all the pH<9. Further, there is a sharp increase in solubility at more alkaline pH>10, with the value being 41.83 mg/mL at pH 13[4].
Sesamol Preparation Products And Raw materials
Raw materials
Preparation Products
1of2
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| Supplier | Advantage |
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| ANJI BIOSCIENCES | 58 |
| RP Industries | 58 |
| Vihita Chem Private Limited | 58 |
| VASISTA LIFE SCIENCES PRIVATE LIMITED | 58 |
| JIVICHEM SYNTHESIS PVT LTD | 58 |
| Regal Remedies Ltd a Fluorine | 58 |
| SYNOVA CHEMICALS | 58 |
| BIOCARE LABORATORIES | 58 |
| JSK Chemicals | 58 |
| CNS CHEMICALS | 58 |