ChemicalBook > Product Catalog >API >Nervous system drugs >Cholinergic drugs >Galantamine Hydrobromide
Galantamine Hydrobromide
- CAS No.
- 1953-04-4
- Chemical Name:
- Galantamine Hydrobromide
- Synonyms
- GALANTAMINE HBR;GALANTHAMINE HBR;NIVALIN;4A,5,9,10,11,12-HEXAHYDRO-3-METHOXY-11-METHYL-6H-BENZOFURO[3A,3,2-EF][2]BENZAZEPIN-6-OL HYDROBROMIDE;(4aS,6R,8aS)-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol, Hydrobromide;NIVALIN, HBR;Galanthamine HCI;GALANTAMINE HYDROBROMIDE;GALANTHAMIDE HYDROBROMIDE;GALANTHAMINE HYDROBROMIDUM
- CBNumber:
- CB2439815
- Molecular Formula:
- C17H22BrNO3
- Molecular Weight:
- 368.27
- MOL File:
- 1953-04-4.mol
- Modify Date:
- 2024/8/21 22:41:43
| Melting point | 256 °C |
|---|---|
| alpha | D20 -93.1° (c = 0.1015 in 15 ml H2O) |
| refractive index | -95 ° (C=1.4, H2O) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | Sparingly soluble in water, very slightly soluble in anhydrous ethanol. It dissolves in dilute solutions of alkali hydroxides. |
| form | White to off-white crystalline solid. |
| color | White to Orange to Green |
| Water Solubility | Soluble in water or DMSO |
| Merck | 14,4340 |
| InChI | InChI=1/C17H21NO3.BrH/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17;/h3-6,12,14,19H,7-10H2,1-2H3;1H/t12-,14-,17-;/s3 |
| InChIKey | QORVDGQLPPAFRS-ORFATOSYNA-N |
| SMILES | [C@@]123CCN(C)CC4=CC=C(OC)C(O[C@H]1C[C@@H](O)C=C2)=C34.Br |&1:0,14,16,r| |
| LogP | 1.750 (est) |
| CAS DataBase Reference | 1953-04-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P405-P501 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25 | |||||||||
| Safety Statements | 45-36/37/39-22 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DF8075000 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29399990 | |||||||||
| Toxicity | LD50 i.v. in mice (mg/kg): 5.2 ± 0.2 (Friess) | |||||||||
| NFPA 704 |
|
Galantamine Hydrobromide price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | G1660 | Galanthamine hydrobromide from Lycoris sp. ≥94% (HPLC) | 1953-04-4 | 2MG | ₹9212.08 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1623 | Galantamine Hydrobromide Pharmaceutical Secondary Standard; Certified Reference Material | 1953-04-4 | 500MG | ₹31901.28 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | G1660 | Galanthamine hydrobromide from Lycoris sp. ≥94% (HPLC) | 1953-04-4 | 10MG | ₹27571.28 | 2022-06-14 | Buy |
| TCI Chemicals (India) | G0293 | Galantamine Hydrobromide | 1953-04-4 | 100MG | ₹11900 | 2022-05-26 | Buy |
| TCI Chemicals (India) | G0293 | Galantamine Hydrobromide | 1953-04-4 | 1G | ₹22900 | 2022-05-26 | Buy |
Galantamine Hydrobromide Chemical Properties,Uses,Production
Chemical Properties
Galantamine hydrobromide is a white to almost white powder and is sparingly soluble in water.
Uses
Galantamine hydrobromide (marketed as Reminyl) is one of a group of three drugs for people with Alzheimer's disease called cholinesterase inhibitors. The other two are called donepezil hydrochloride (common brand name Aricept) and rivastigmine (common brand name Exelon). It is a selective acetylcholinesterase inhibitor that for the treatment and prevention of Alzheimer's disease and other diseases resulting from reduced neuronal metabolism.
General Description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Galantamine Hydrobromide, a reversible, competitive acetyl cholinesterase inhibitor, is suggested for the remedy of mild to moderate dementia of the Alzheimer′s type.
Biological Activity
Long-acting, centrally active acetylcholinesterase inhibitor (IC 50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. Prevents β -amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. Long-term administration reduces amyloid precursor protein deposition and neurodegeneration in a mouse model of Alzheimer's disease.
Galantamine Hydrobromide Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 419)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Aurobindo Pharma Limited | +914066725000 | Telangana, India | 112 | 58 | Inquiry |
| Hetero Drugs Limited | +91-4023704923 +91-4023704923 | Telangana, India | 296 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4317 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Omcham Labs | 08048372728Ext 857 | Gujarat, India | 90 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12447 | 58 | Inquiry |
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GALANTAMINE HBR
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NIVALIN
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(4aS,6R,8aS)-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol, Hydrobromide
1953-04-4
4/4/1953
19-45-3
C17H22BrNO3
C17H21NO3HBr
C17H21NO3xHBr
C17H21NO3HBrC17H22BrNO3
C17H22NO3Br
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