2-Aminoadenosine
- CAS No.
- 2096-10-8
- Chemical Name:
- 2-Aminoadenosine
- Synonyms
- 2-NH2-A;Aminoadenosine;2-AMINE ADENOSINE;2,6-DIAMINOPURINE RIBOSIDE;0/8/96;NSC 7363;2-NH2-Ar;2-NH2-rA;2-NH?-rA;2-AMinoadenosin
- CBNumber:
- CB2468756
- Molecular Formula:
- C10H14N6O4
- Molecular Weight:
- 282.26
- MOL File:
- 2096-10-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/29 15:24:14
| Melting point | 241-243°C (dec.) |
|---|---|
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Aqueous Acid (Slightly, Heated, Sonicated), DMSO (Slightly, Sonicated), Ethanol |
| form | Powder |
| Boiling point | 798.5±70.0 °C(Predicted) |
| Density | 2.25±0.1 g/cm3(Predicted) |
| pka | 13.10±0.70(Predicted) |
| color | White to Off-White |
| InChIKey | ZDTFMPXQUSBYRL-UUOKFMHZSA-N |
| CAS DataBase Reference | 2096-10-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Safety Statements | 24/25 | |||||||||
| HS Code | 29389090 | |||||||||
| NFPA 704 |
|
2-Aminoadenosine price More Price(2)
2-Aminoadenosine Chemical Properties,Uses,Production
Description
2-Aminoadenosine is a known analogue of adenosine that engages in three hydrogen bonds of the W-C type, adding considerable stability to the double helix.
Chemical Properties
White Powder
Uses
2-Aminoadenosine is a nucleoside analog as inhibitor or substrate of adenosine kinase from M. tuberculosis. It is also used to synthesize 2′-O-methyl and 3′-O-methyl Guanosine.
Definition
ChEBI: 2-Aminoadenosine is a purine nucleoside.
Synthesis
The synthesis of 2-aminoadenosine (2-AA): Assays were performed in 5 and 10% of aprotic dipolar co-solvents, at 60°C, twelve units/ml cell lysate were added to 150 ml of a solution kept thermostatically at 60 °C, and having the following composition of substrate solutions: 15mM Uridine/2 ' -Deoxyuridine,5 mM 2,6-Diaminopurine, and 30 mM potassium phosphate buffer, pH 7. After 5 hours, the reaction mixture was filtered by centrifugation at 2000 x g for 30 min, at 4°C, through an Amicon ultra-4 Centrifugal Filter Devices (Millipore, Bedford, MA) with a 3000-Da cutoff, and the filtrate was recovered. 
References
Pyrazolo[3,4-d]pyrimidine ribonucleosides related to 2-aminoadenosine and isoguanosine: synthesis, deamination and tautomerism. DOI: 10.1039/B708736E
An Efficient Process for Synthesis of 2′-O-methyl and 3′-O-methyl Guanosine from 2-aminoadenosine Using Diazomethane and the Catalyst Stannous Chloride. DOI: 10.1080/15257770500544529
2-Aminoadenosine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
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