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Coenzyme B12

Coenzyme B12 Structure
CAS No.
13870-90-1
Chemical Name:
Coenzyme B12
Synonyms
COBAMAMIDE;adenosylcobalamin;dibencozide;COENZYME B12;lm176;AdoCbl;COBAMIDE;calomide;funacomide;enzyme B12
CBNumber:
CB8433734
Molecular Formula:
C72H99CoN18O17P
Molecular Weight:
1578.6
MOL File:
13870-90-1.mol
MSDS File:
SDS
Modify Date:
2024/4/29 22:41:02
Request For Quotation

Coenzyme B12 Properties

storage temp. -20°C
solubility DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated)
form Solid
pka 3.5(at 25℃)
color Red to Very Dark Red
Water Solubility 26g/L(24 ºC)
Merck 13,2476
BRN 4122932
Stability Hygroscopic
InChIKey WAJLPPDUWGAMTH-NGQUPMDYNA-L

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  22-24/25-36-26
WGK Germany  3
RTECS  GG3800000
F  8
HS Code  2936260000
Toxicity LD50 oral in guinea pig: 5gm/kg

Coenzyme B12 price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) C0884 Coenzyme B12 ≥97.0% 13870-90-1 25MG ₹6365.1 2022-06-14 Buy
Sigma-Aldrich(India) C0884 Coenzyme B12 ≥97.0% 13870-90-1 100MG ₹9720.85 2022-06-14 Buy
Sigma-Aldrich(India) C0884 Coenzyme B12 ≥97.0% 13870-90-1 250MG ₹16324.1 2022-06-14 Buy
Sigma-Aldrich(India) C0884 Coenzyme B12 ≥97.0% 13870-90-1 1G ₹43007.73 2022-06-14 Buy
Product number Packaging Price Buy
C0884 25MG ₹6365.1 Buy
C0884 100MG ₹9720.85 Buy
C0884 250MG ₹16324.1 Buy
C0884 1G ₹43007.73 Buy

Coenzyme B12 Chemical Properties,Uses,Production

Description

Coenzyme B12 (adenosylcobalamin; AdoCbl; 5'-Deoxyadenosylcobalamin) is a form of vitamin B12. It belongs to the corrinoid group of compounds containing a corrin macrocycle and are produced only by certain bacteria and archaea. It is a cofactor for various enzymes, including mutases, eliminases, aminomutases, and reductases. These enzymes catalyze reactions that generate free radicals through the release of the adenosyl group, allowing usually unreactive molecules to become reactive. Genetic mutations in enzymes synthesizing Coenzyme B12 lead to Coenzyme B12 deficiency and methylmalonic aciduria.

Uses

emulsifying agent

Definition

ChEBI: A member of the class of cobalamins that is vitamin B12 in which the cyano group is replaced by a 5'-deoxyadenos-5'-yl moiety. It is one of the two metabolically active form of vitamin B12.

Definition

Coenzyme B12 (5'-Deoxy-5'-adenosylcobalamin or Ado-Cbl) is the largest molecule among the B type vitamins. It is an essential cofactor in many biological rearrangement reactions. Coenzyme B12 activates enzymes such as methionine synthase (MetH), methyl-malonyl-CoA mutase (MutAB), and glycerol dehydratase (DhaB). Biologically, coenzyme B12 is one of the two main types of vitamin B12, adenosyl-cobalamin and methyl-cobalamin, and the former is highly preferred for many enzymes, including glycerol and diol dehydratases[1].

Biotechnological Production

There exist two distinctive routes for the biosynthesis of coenzyme B12, namely oxygen-dependent (encoded by cob operons) and oxygen-independent (by CBI operons) pathways. Their requirement of molecular oxygen during synthesis and the point at which cobalt is inserted into the corrin ring. De novo coenzyme B12 biosynthesis is limited to some bacteria and archaea. The aerobic pathway is present in Pseudomonas denitrificans, Sinorhizobium meliloti, Rhodobacter sphaeroides and Pseudomonas aeruginosa. At the same time, the anaerobic one is present in Salmonella typhimurium, Klebsiella pneumoniae, Citrobacter amalonaticus, Bacillus megaterium, Propionibacterium shermanii and Lactobacillus reuteri.

General Description

Vitamin B12 cobalamin refers to a group of chemically-related cobalt containing molecules. The physiologically active forms of vitamin B12 include methylcobalamin and adenosylcobalamin, whereas hydroxocobalamin (vitamin B12a, OHCbl) and cyanocobalamin (CNCbl) are storage and delivery forms.

Agricultural Uses

Cobamide enzyme is the cobalt complex formed between the cobalt-porphyrin ring structure and the nucleotide in vitamin B12 co-enzyme.

References

[1] Thuan Phu Nguyen-Vo. “Analysis and characterization of coenzyme B12 biosynthetic gene clusters and improvement of B12 biosynthesis in Pseudomonas denitrificans ATCC 13867.” Fems Microbiology Letters 365 21 (2018).
[2] I. I. Merkelbach, Hm Henk Buck. “Mechanism of action of coenzyme B12. Quantum-chemical considerations.” Recueil des Travaux Chimiques des Pays-Bas 28 1 (2010): 166–169.
[3] Prof. Dr. Karl Gruber, Prof. Dr. Bernhard Krutler. “Coenzyme B12 Repurposed for Photoregulation of Gene Expression.” Angewandte Chemie International Edition 55 19 (2016): 5638–5640.

Coenzyme B12 Preparation Products And Raw materials

Raw materials

Chlortetracycline Sodium cyanide Hydrochloric acid

Preparation Products

Coenzyme B12 Suppliers

Global( 248)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Deccan Nutraceuticals Pvt. Ltd +91-9822641298 +91-9822641298 Mumbai, India 18 58 Inquiry
Ralington Pharma +91-7948911722 +91-9687771722 Gujarat, India 1350 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Triveni chemicals 08048762458 New Delhi, India 6093 58 Inquiry
MANGALAM DRUGS AND ORGANICS LIMITED 08147509329 Uttar Pradesh, India 50 58 Inquiry
Apex Medichem Pvt. Ltd. 91-2431-232372 Maharashtra, India 11 58 Inquiry
Clearsynth Labs 91-22-45045900 Maharashtra, India 3889 58 Inquiry
Shagun Pharmaceuticals 91-731-2575029 Madhya Pradesh, India 193 58 Inquiry
Chemsynth Drugs & Pharmaceuticals Pvt Ltd. 91-11-43005480 Delhi, India 71 58 Inquiry
Supplier Advantage
Deccan Nutraceuticals Pvt. Ltd 58
Ralington Pharma 58
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Triveni chemicals 58
MANGALAM DRUGS AND ORGANICS LIMITED 58
Apex Medichem Pvt. Ltd. 58
Clearsynth Labs 58
Shagun Pharmaceuticals 58
Chemsynth Drugs & Pharmaceuticals Pvt Ltd. 58

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13870-90-1(Coenzyme B12)Related Search:

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DIMETHYLBENZIMIDAZOLYLCOBAMIDE COENZYME, 5,6- DMBC COENZYME COBAMAMIDE/DIBENCOZIDE COBAMIDE 5'-deoxyadenosylcobalamin 5'-DEOXYADENOSYLCOBALAMINE ADENOSYL COBALAMINE 5,6-DIMETHYLBENZIMIDAZOLYLCOBAMIDE COENZYME ster),innersalt,3’-esterwith5,6-dimethyl-1-alpha-d-ribofuranosylbenzimidaz coenzyme B12 crystalline Cobamamide/VitaminB12 Coenzyme B12 ADENOSYLCOBALAMINE(COENZYME B12)(RG) COBAMAMIDE (PYROGEN FREE) 5μ-Deoxyadenosylcobalamine, Adenosyl cobalamine, Cobamamide, DMBC coenzyme cobalaminecoenzyme cobinamide,o-(5’-deoxyadenosine-5’)deriv.,hydroxide,dihydrogenphosphate(e dbccoenzyme deoxyadenosylcobalamin funacomide lm176 ADENOSYLCOBALAMINE(COENZYME B12)(P) Coenzyme B12,5′-Deoxyadenosylcobalamine, Adenosyl cobalamine, Cobamamide, DMBC coenzyme ADENOSYLCOBALAMINE(COENZYME B12)(AS) CobinaMide,Co-(5'-deoxyadenosin-5'-yl)-, f-(dihydrogen phosphate), inner salt, 3'-esterwith (5,6-diMethyl-1-a-D-ribofuranosyl-1H-benziMidazole-kN3) (9CI) COENZYME B12, >=97.0% 5’-deoxyadenosylvitaminb12 calomide Cobamamide (Dibencozide, Coenzyme B12) Cyanocobalamin Impurity 14 AdoCbl Cobamamide， DMBC coenzyme Cobinamide, Co-(5'-deoxyadenosin-5'-yl)-, f-(dihydrogen phosphate),inner salt, 3'-ester with(5,6-dimethyl-1-a-D-ribofuranosyl-1H-benzimidazole-kN3) 5'-Deoxyadenosylcobalamin USP/EP/BP COENZYME B12 COBAMAMIDE dibencozide adenosylcobalamin (2S,3S,4R,5R)-2-(6-Aminopurin-9-yl)-5-methanidyloxolane-3,4-diol Cyanocobalamin Impurity K enzyme B12 [(2R,3S,4R,5S)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2R)-1-[3-[(1R,2R,3R,4Z,7S,9Z,12S,13S,14Z,17S,18S,19R)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7,12,17-tetrahydro-1H-corrin-21-id-3-yl]propanoylamino]propan-2-yl] hydrogen phosphate ADENOSYLCOBALAMINE(COENZYME B12) Cobamamide (Active Vitamin B12) 13870-90-1 C72Co1H100N18O17P1 C72H100CoN18O17P Other Cofactors Enzymes, Inhibitors, and Substrates Cofactors Biochemicals and Reagents BioChemical Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts PHARMACEUTICALS