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NADOLOL

NADOLOL Structure
CAS No.
42200-33-9
Chemical Name:
NADOLOL
Synonyms
1-(tert-Butylamino)-3-((5,6,7,8-tetrahydro-cis-6,7-dihydroxy-1-naphthyl)oxy)-2-propanol;Solgol;Corgard;corzide;Begen;Nadic;Anabet;NADOLOL;2,3-diol;SQ 11725
CBNumber:
CB2494641
Molecular Formula:
C17H27NO4
Molecular Weight:
309.4
MOL File:
42200-33-9.mol
MSDS File:
SDS
Modify Date:
2024/12/18 14:07:02

NADOLOL Properties

Melting point 125-130°C
Boiling point 449.67°C (rough estimate)
Density 1.0449 (rough estimate)
refractive index 1.5420 (estimate)
storage temp. Refrigerator
solubility Slightly soluble in water, freely soluble in ethanol (96 per cent), practically insoluble in acetone.
pka 9.67(at 25℃)
form Solid
color White to Off-White
Water Solubility 8.30g/L(25 ºC)
BCS Class 3
EPA Substance Registry System 2,3-Naphthalenediol, 5-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-1,2,3,4-tetrahydro- (42200-33-9)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
WGK Germany  2
RTECS  QJ4870000
HS Code  2922190900
Hazardous Substances Data 42200-33-9(Hazardous Substances Data)
Toxicity LD50 in mice, rats (mg/kg): 4500, 5300 orally (Antonaccio, Evans)

NADOLOL price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) N1892 Nadolol analytical standard 42200-33-9 1G ₹8064.63 2022-06-14 Buy
Sigma-Aldrich(India) N1892 Nadolol analytical standard 42200-33-9 5G ₹78199.8 2022-06-14 Buy
Product number Packaging Price Buy
N1892 1G ₹8064.63 Buy
N1892 5G ₹78199.8 Buy

NADOLOL Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

Labelled Nadolol (N201052). β-Adrenergic

Metabolism

Nadolol (Corgard) is slowly and incompletely absorbed from the gastrointestinal tract, and only 30% of an orally administered dose is absorbed. Appreciable metabolism does not seem to occur; nadolol is excreted primarily unchanged in the urine and feces.The plasma half-life is quite long, approaching 24 hours, which permits dosing once per day.

NADOLOL Preparation Products And Raw materials

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1-(tert-butylamino)-3-((5,6,7,8-tetrahydro-cis-6,7-dihydroxy-1-naphthyl)oxy) 1-(tert-bytylamino)-3-((5,6,7,8-tetrahydro-cis-6,7-dihydroxy-1-naphthyl)oxy)-2 2,3-cis-1,2,3,4-tetrahydro-5-((2-hydroxy-3-tert-butylamino)propoxy)-2,3-naph 2,3-cis-1,2,3,4-Tetrahydro-5-((2-hydroxy-3-tert-butylamino)propoxy)-2,3-naphthalenediol 2,3-cis-1,2,3,4-tetrahydro-5-(2-hydroxy-3-(tert-butylamino)propoxy)-2,3-naphth 2,3-diol 2,3-Naphthalenediol, 5-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-1,2,3,4-tetrahydro- 2,3-Naphthalenediol, 5-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-1,2,3,4-tetrahydro-, cis- 3s)-5-(3-(tert-butylamino)-2-hydroxypropoxy)-1,2,3,4-tetrahydronaphthalene-(2 5-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)-1,2,3,4-3-naphthalenediol 5-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)-1,2,3,4-tetrahydro-2,3-nap 5-(3-((1,1-Dimethylethyl)amino)-2-hydroxypropoxy)-1,2,3,4-tetrahydro-2,3-naphthalenediol 5-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxyl)-1,2,3,4-tetrahydro-2,3-naph 5-[3-(tert-Butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydro-2,3-naphthalenediol alenediol Anabet hthalenediol SQ 11725 thalenediol NADOLOL NADOLOL-D9 NADOLOL,USP 2,3-Naphthalenediol, 5-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-1,2,3,4-tetrahydro- (9CI) Begen Nadic Nadolol (200 mg) 5-[3-[(1,1-DiMethylethyl)aMino]-2-hydroxypropoxy]-1,2,3,4-tetrahydro- 5-[3-[(1,1-DiMethylethyl-d9)aMino]-2-hydroxypropoxy]-1,2,3,4-tetrahydro- (2R,3R)-5-[3-(tert-butylaMino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol (2R,3S)-5-(3-(tert-Butylamino)-2-hydroxypropoxy)-1,2,3,4-tetrahydronaphthalene-2,3-diol -1,2,3,4-tetrahydronaphthalene-2,3-diol -2-hydroxypropoxy) -5-(3-(tert-Butylamino) Nadolol (1449700) NadololQ: What is Nadolol Q: What is the CAS Number of Nadolol Q: What is the storage condition of Nadolol Q: What are the applications of Nadolol NADOLOL USP/EP/BP cis-5-[(2RS)-3-[(1,1-Dimethylethyl)amino]-2- hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol Nadolol-d5 Nadolol CRS 1-(tert-Butylamino)-3-((5,6,7,8-tetrahydro-cis-6,7-dihydroxy-1-naphthyl)oxy)-2-propanol Corgard corzide Solgol pressure,Adrenergic Receptor,Nadolol,pectoris,substrate,SQ-11725,high,β-adrenergic,OATP1A2,Beta Receptor,inhibit,vascular,blood,headaches,SQ 11725,Inhibitor,angina Nadolol in methanol Nadolol 10 μg/ml Acetonitrile 42200-33-9 C17H18D9NO4 Alphabetic NA - NI Analytical Chromatography Product Catalog Analytical Standards RITALIN Isotopically Labeled Pharmaceutical Reference Standard Amines Aromatics Intermediates & Fine Chemicals Pharmaceuticals