CYLINDROSPERMOPSIN
- CAS No.
- 143545-90-8
- Chemical Name:
- CYLINDROSPERMOPSIN
- Synonyms
- cylindrospermopsin;PubChem ID: 42628600;5a-alpha,7-beta(r*))-(-)-h;sulfooxy)-1h-1,8,8b-triazaacenaphthylen-7-yl)methyl)-,(2a-alpha,3-alpha,4-alp;2,4(1h,3h)-pyrimidinedione,6-(hydroxy(2,2a,3,4,5,5a,6,7-octahydro-3-methyl-4-(;6-[(R)-Hydroxy[(2aS,3R,4S,5aS,7R)-2,2a,3,4,5,5a,6,7-octahydro-3-methyl-4-(sulfooxy)-1H-1,8,8b-triazaacenaphthylen-7-yl]methyl]-2,4(1H,3H)-pyrimidinedione;2,4(1H,3H)-Pyrimidinedione, 6-[(R)-hydroxy[(2aS,3R,4S,5aS,7R)-2,2a,3,4,5,5a,6,7-octahydro-3-methyl-4-(sulfooxy)-1H-1,8,8b-triazaacenaphthylen-7-yl]methyl]-
- CBNumber:
- CB2503323
- Molecular Formula:
- C15H21N5O7S
- Molecular Weight:
- 415.42
- MOL File:
- 143545-90-8.mol
- Modify Date:
- 2023/7/14 17:49:00
| Density | 1.3937 (rough estimate) |
|---|---|
| refractive index | 1.6460 (estimate) |
| storage temp. | −20°C |
| solubility | DMSO: soluble |
| form | white powder |
| pka | -3.78±0.18(Predicted) |
| EPA Substance Registry System | Cylindrospermopsin (143545-90-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H341-H300-H370 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501-P260-P264-P270-P307+P311-P321-P405-P501-P201-P202-P281-P308+P313-P405-P501 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UV9104310 | |||||||||
| Toxicity | mouse,LD50,intraperitoneal,2100ug/kg (2.1mg/kg),LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"BLOOD: CHANGES IN SPLEENKIDNEY, URETER, AND BLADDER: OTHER CHANGES,Toxicologist. Vol. 14, Pg. 211, 1994. | |||||||||
| NFPA 704 |
|
CYLINDROSPERMOPSIN Chemical Properties,Uses,Production
Description
Cylindrospermopsin, a tricyclic uracil derivative, is a cyanobacterial toxin that was first discovered in an algal bloom contaminating a local drinking supply on Palm Island in Queensland, Australia after an outbreak of a mysterious disease. Cylindrospermopsin targets protein and glutathione synthesis in hepatocytes (IC50s = 1.3 and 2.4 μM, respectively), leading to cell death. It has been shown to inhibit the activity of the uridine monophosphate synthase complex with a Ki value of 10 μM. Cylindrospermopsin is genotoxic, inducing DNA damage as evidenced by double strand breaks and reducing cell viability in HepG2 cells at 0.1-
Uses
Cylindrospermopsin is a cyanotoxin produced by cyanobacterial species and found in many bodies of water.
Definition
ChEBI: A triazaacenaphthylene that is 2,2a,3,4,5,5a,6,7-octahydro-1H-1,8,8b-triazaacenaphthylene which is substituted at positions 3, 4, and 7 by methyl, sulfooxy, and (2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)(hydroxy)methyl groups, respecti ely (the 2aS,3R,4S,5aS,7R stereoisomer in which the carbon bearing the hydroxy group has R configuration). It is a cyanotoxin produced by several species f freshwater cyanobacteria, such as Aphanizomenon ovalisporum.
CYLINDROSPERMOPSIN Preparation Products And Raw materials
Raw materials
Preparation Products
CYLINDROSPERMOPSIN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| BOC Sciences | 16314854226; +16314854226 | United States | 19743 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |
| BOC Sciences | USA | 0 | 65 | Inquiry | |
| Naturewill Biotechnology Co., Ltd. | 18113192475 18113192475 | China | 5000 | 58 | Inquiry |
| Changzhou Xianglong Pharmaceutical Technology Co., LTD | 0519-88910898 18661161657 | China | 9998 | 58 | Inquiry |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | China | 8141 | 58 | Inquiry |
| cjbscvictory | 13348960310 13348960310 | China | 10011 | 58 | Inquiry |
| Zhejiang Huida Biotech Co., LTD | 0571-0571-89903882 15990081639 | China | 3705 | 58 | Inquiry |
| Zhejiang Huida Biotech Co., LTD | 0571-89903882 13626641628 | China | 3656 | 58 | Inquiry |
143545-90-8(CYLINDROSPERMOPSIN)Related Search:
1of3
chevron_right