Denatonium Benzoate
- CAS No.
- 3734-33-6
- Chemical Name:
- Denatonium Benzoate
- Synonyms
- DENATONIUM BENZOATE;BITREX;denatonium;,benzoate;REJEXIT (R);Bitrex? Denatonium Benzoate;Acetylthio-2-Methylpro-Panoyl Chloride;benzyldiethyl (2,6-xylylcarbamoylmethyl)-ammonium;Vilex;ths-839
- CBNumber:
- CB2674421
- Molecular Formula:
- C28H34N2O3
- Molecular Weight:
- 446.58
- MOL File:
- 3734-33-6.mol
- Modify Date:
- 2024/8/8 18:06:34
| Melting point | 164-168 °C (lit.) |
|---|---|
| Boiling point | 555.91°C (rough estimate) |
| Density | 1.1256 (rough estimate) |
| vapor pressure | 0Pa at 25℃ |
| refractive index | 1.5800 (estimate) |
| Flash point | 100℃ |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | methanol: 50 mg/mL, clear, colorless |
| form | Solid |
| color | White to Off-White |
| Odor | at 100.00?%. bland |
| Water Solubility | 42.555g/L at 25℃ |
| Merck | 14,2891 |
| BRN | 8179408 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | VWTINHYPRWEBQY-UHFFFAOYSA-N |
| LogP | 2.2 at 25℃ |
| CAS DataBase Reference | 3734-33-6(CAS DataBase Reference) |
| EPA Substance Registry System | Denatonium benzoate (3734-33-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H412 | |||||||||
| Precautionary statements | P264-P270-P273-P301+P312-P501 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38-20/21/22 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | BO6650000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29242995 | |||||||||
| NFPA 704 |
|
Denatonium Benzoate price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | D5765 | Denatonium benzoate ≥98% | 3734-33-6 | 1G | ₹4968.68 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D5765 | Denatonium benzoate ≥98% | 3734-33-6 | 5G | ₹12210.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D5765 | Denatonium benzoate ≥98% | 3734-33-6 | 10G | ₹22949 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 93675 | Denatonium benzoate certified reference material, TraceCERT? | 3734-33-6 | 100MG | ₹8616.7 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 52487 | Denatonium benzoate PESTANAL?, analytical standard | 3734-33-6 | 100MG | ₹6603.25 | 2022-06-14 | Buy |
Denatonium Benzoate Chemical Properties,Uses,Production
Chemical Properties
white crystals
Production Methods
Denatonium benzoate was first synthesized in the 1950s and is usually prepared by reacting denatonium chloride with benzyl benzoate.
Pharmaceutical Applications
Denatonium benzoate is among the most bitter of substances
known and is detectable at concentrations of approximately 10 ppb.
In pharmaceutical and other industrial applications it is added to
some products as a deterrent to accidental ingestion. It is most
commonly used at levels of 5–500 ppm. Denatonium benzoate may
also be used to replace brucine or quassin as a denaturant for
ethanol.
In pharmaceutical formulations, denatonium benzoate has been
used as a flavoring agent in placebo tablets, and in a topical
formulation it has been used in an anti-nailbiting preparation.
Safety
Denatonium benzoate is generally regarded as a nonirritant and nonmutagenic substance.However,therehasbeenasinglereportof contact urticaria attributed to denatonium benzoate occurring in a 30-year-old man who developed asthma and pruritus after using an insecticidal spray denatured with denatonium benzoate.
LD50 (rabbit, oral): 0.508g/kg
LD50 (rat, oral): 0.584g/kg
Synthesis
A method for synthesizing Denatonium Benzoate comprises the following steps: (1) adding benzyl halide to a reactor containing raw material lidocaine under stirring and at a certain temperature, wherein the reaction temperature is from room temperature to 130°C, and the ratio of lidocaine to benzyl halide is 1:1 to 1:2; (2) after the reaction is complete, adding solvent and metal hydroxide; (3) adding benzoic acid, after the reaction is completed, the generated benzyl ammonium benzoate is filtered, washed, concentrated, and washed to obtain the product benzyl ammonium benzoate.
storage
Denatonium benzoate is stable up to 140°C and over a wide pH range. It should be stored in a well-closed container (such as polythene-lined steel) in a cool, dry place. Aqueous or alcoholic solutions retaintheir bitterness forseveral years evenwhenexposed to light.
Incompatibilities
Denatonium benzoateis incompatible with strongoxidizing agents.
Regulatory Status
Denatonium benzoate is used worldwide as a denaturant for alcohol. It is included in the FDA Inactive Ingredients Database (topical gel and solution).
Denatonium Benzoate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| ADVENT CHEMBIO PRIVATE LIMITED | +91-9821524116 +91-9821524116 | Mumbai, India | 353 | 58 | Inquiry |
| SHIVAM INDUSTRIES | +91-9820823043 +91-9820823043 | Mumbai, India | 30 | 58 | Inquiry |
| Dhaval Dyes | +91-2692233774 +91-2692236143 | Gujarat, India | 2 | 58 | Inquiry |
| United Phosphorus Limited | +91-2271528737 +91-9004390689 | Mumbai, India | 32 | 58 | Inquiry |
| A.B.ENTERPRISES | +91-9223381464 +91-9223381464 | Maharashtra, India | 78 | 58 | Inquiry |
| Nikita Transphase Adducts Private Limited | +91-2224440141 +91-2266158844 | Maharashtra, India | 3 | 58 | Inquiry |
| Sunmoon Pharmaceuticals Pvt Ltd | +91-9823134983 +91-9890725812 | Maharashtra, India | 17 | 58 | Inquiry |
| The Lakshmiji Organics Pvt Ltd | +91-9721453102 +91-9322661064 | Uttar Pradesh, India | 3 | 58 | Inquiry |
| White Star Pigments & Chemicals | 91 224137567 | New Delhi, India | 15 | 83 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
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