Glycyrrhizic acid ammonium salt
- CAS No.
- 53956-04-0
- Chemical Name:
- Glycyrrhizic acid ammonium salt
- Synonyms
- MONOAMMONIUM GLYCYRRHIZINATE;Magnasweet;monoammoniumglycyrrhizate;glycyrrhizin monoammonium salt;Monoammonium Glycyrrhizinate S;GLYCYRRHIZINATE MONOAMMONIUM SALT;GLYCYRRHIZIC ACID MONOAMMONIUM SALT;GLYCAMIL;icorice);t from g
- CBNumber:
- CB1492372
- Molecular Formula:
- C42H65NO16
- Molecular Weight:
- 839.97
- MOL File:
- 53956-04-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/8 18:06:34
| Melting point | >200°C (dec.) |
|---|---|
| Boiling point | 768.56°C (rough estimate) |
| Density | 1.1846 (rough estimate) |
| FEMA | 2528 | GLYCYRRHIZIN, AMMONIATED (GLYCYRRHIZA SPP.) |
| refractive index | 49 ° (C=1.5, EtOH) |
| storage temp. | 2-8°C |
| solubility | Slightly soluble in water, very slightly soluble in anhydrous ethanol, practically insoluble in acetone. It dissolves in dilute solutions of acids and of alkali hydroxides. |
| form | Powder or Crystals |
| color | Yellow to yellow-green |
| Odor | bland |
| optical activity | [α]20/D +48±4°, c = 1% in ethanol: water (1:1) |
| BRN | 3897076 |
| Stability | Hygroscopic |
| InChIKey | ILRKKHJEINIICQ-YDYGGSECSA-N |
| LogP | -0.9 |
| CAS DataBase Reference | 53956-04-0 |
| EPA Substance Registry System | .alpha.-D-Glucopyranosiduronic acid, (3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-.beta.-D-glucopyranuronosyl-, monoammonium salt (53956-04-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313 | |||||||||
| RIDADR | UN 3077 9 / PGIII | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | LZ6500000 | |||||||||
| F | 3-10 | |||||||||
| HS Code | 29389090 | |||||||||
| NFPA 704 |
|
Glycyrrhizic acid ammonium salt price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | G2137 | Glycyrrhizic acid ammonium salt from glycyrrhiza root (licorice) ≥70% (HPLC) | 53956-04-0 | 25G | ₹7599.15 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | G2137 | Glycyrrhizic acid ammonium salt from glycyrrhiza root (licorice) ≥70% (HPLC) | 53956-04-0 | 100G | ₹14083.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 50531 | Glycyrrhizic acid ammonium salt from glycyrrhiza root (licorice) ≥95.0% (NT) | 53956-04-0 | 10G | ₹6072.83 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 91443 | Glycyrrhizic acid ammonium salt analytical standard, suitable for HPLC | 53956-04-0 | 10MG | ₹12513.7 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 50531 | Glycyrrhizic acid ammonium salt from glycyrrhiza root (licorice) ≥95.0% (NT) | 53956-04-0 | 50G | ₹21087.1 | 2022-06-14 | Buy |
Glycyrrhizic acid ammonium salt Chemical Properties,Uses,Production
Description
§ 184.1408(a)(1) Licorice (glycyrrhiza) root is the dried and ground rhizome and root portions of Glycyrrhiza glabra or other species of glycyrrhiza. Licorice extract is that portion of the licorice root that is, after maceration, extracted by boiling water. The extract can be further purified by filtration and by treatment with acids and ethyl alcohol. Licorice extract is sold as a liquid paste ("block"), or spraydried powder. (2) Ammoniated glycyrrhizin is prepared from the water extract of licorice root by acid precipitation followed by neutralization with dilute ammonia. Monoammonium glycyrrhizinate (C42H61016NH45H2O ) is prepared from ammoniated glycyrrhizin by solvent extraction and separation techniques.
Chemical Properties
white to slightly yellow powder
Uses
Glycyrrhizic acid ammonium salt is a flavoring and sweetening agent obtained from licorice flavonoids. It has a slight licorice flavor and an intense and rounded sweetness. It is soluble in water, glycerin, and propylene glycol and has good thermal stability but can degrade under prolonged heating. It is stable over a ph of 3.5–9 but could precipitate below ph of 3.5. It can be used in beverages, desserts, confectionary products, soups, and dressings.
General Description
Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.
Anticancer Research
Glycyrrhizin (GL) is a saponin-like compound that provides the main sweet flavourfor G. glabra (licorice), and it is commonly used in clinical treatment for itsoutstanding pharmacological action such as antitumour, anti-inflammatory andanti-oxidativeactions (Rebhun et al. 2015; Wu et al. 2015). Cai et al. (2017) triedto evaluate the anticancer properties of GA and GL against TNBC in combinationwith etoposide.
Safety Profile
Moderately toxic by intravenous route. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NH3.
Purification Methods
Crystallise the ammonium salt from glacial acetic acid, then dissolve it in ethanolic ammonia and evaporate. The pentahydrate forms needles from 75% aqueous EtOH, m 212-217o. The free acid crystallises from glacial acetic acid. [Karrer et al. Helv Chim Acta 4 100 1921, Lithgoe & Tripett J Chem Soc 1983, 1987 1950, Beilstein 18 IV 5156.]
Glycyrrhizic acid ammonium salt Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Sunpure Extracts Pvt Ltd | +91-1203761106 +91-1203761106 | New Delhi, India | 4 | 58 | Inquiry |
| Sami Sabinsa Group Limited (formerly Sami Labs Limited) | +91-8028397978 +91-9972587319 | Karnataka, India | 66 | 58 | Inquiry |
| Alchem International Pvt Ltd | +91-1126809882 +91-1126809882 | New Delhi, India | 15 | 58 | Inquiry |
| Natural Remedies Pvt Ltd | +91 (80) 4020-9999 | New Delhi, India | 110 | 50 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Sv Agro Food | +91-8048758435 | Delhi, India | 37 | 58 | Inquiry |