Sodium hyaluronate
- CAS No.
- 9067-32-7
- Chemical Name:
- Sodium hyaluronate
- Synonyms
- hyaluronic;Hyaluronate;HYALURONIC ACID SODIUM;Sph;HYALURONIC ACID SODIUM SALT;Hyaluronesodium;Sodium Hyaluronic;3000 Da;HYALURONIC ACID NA-SALT;sodium hyaluronate powder
- CBNumber:
- CB4176691
- Molecular Formula:
- C14H22NNaO11
- Molecular Weight:
- 403.31
- MOL File:
- 9067-32-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/27 13:31:27
| Melting point | >209°C (dec.) |
|---|---|
| alpha | D25 -74° (c = 0.25 in water): Rapport et al., J. Am. Chem. Soc. 73, 2416 (1951) |
| storage temp. | -20°C |
| solubility | H2O: 5 mg/mL, clear, colorless |
| form | Powder |
| color | White to cream |
| PH | pH(2g/l,25℃) : 5.5～7.5 |
| Water Solubility | SOLUBLE |
| Merck | 13,4776 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | MAKUBRYLFHZREJ-JWBQXVCJSA-M |
| SMILES | [C@@H]1(O[C@H]2[C@H](O)[C@H]([C@H](O)O[C@@H]2C(=O)[O-])O)O[C@H](CO)[C@@H](O)C[C@H]1NC(=O)C.[Na+] |&1:0,2,3,5,6,9,15,18,21,r| |
| LogP | -6.623 (est) |
| CAS DataBase Reference | 9067-32-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Hazard Codes | B,Xi | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 22-24/25-36/37/39-27-26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | MT7250000 | |||||||||
| F | 3-10 | |||||||||
| HS Code | 39139000 | |||||||||
| Toxicity | LD50 oral in rabbit: > 1gm/kg | |||||||||
| NFPA 704 |
|
Sodium hyaluronate price More Price(81)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | H7630 | Hyaluronic acid sodium salt from bovine vitreous humor | 9067-32-7 | 10MG | ₹32171.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | H9390 | Hyaluronic acid sodium salt from Streptococcus zooepidemicus bacterial glycosaminoglycan polysaccharide | 9067-32-7 | 1G | ₹39143.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | H5388 | Hyaluronic acid sodium salt from rooster comb avian glycosaminoglycan polysaccharide | 9067-32-7 | 100MG | ₹11745.13 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | H7630 | Hyaluronic acid sodium salt from bovine vitreous humor | 9067-32-7 | 50MG | ₹77485.35 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | H5388 | Hyaluronic acid sodium salt from rooster comb avian glycosaminoglycan polysaccharide | 9067-32-7 | 250MG | ₹18467.45 | 2022-06-14 | Buy |
Sodium hyaluronate Chemical Properties,Uses,Production
Chemical Properties
The PhEur 6.3 describes sodium hyaluronate as the sodium salt of hyaluronic acid, a glycosaminoglycan consisting of D-glucuronic acid and N-acetyl-D-glucosamine disaccharide units. Sodium hyaluronate occurs as white to off-white powder or granules. It is very hygroscopic.
Uses
sodium hyaluronate is used as a humectant to increase moisture in the skin, it may also serve as an emulsifier. Sodium hyaluronate is capable of binding 1,800 times its own weight in water. It is the sodium salt of hyaluronic acid and is the most commonly used form.
Production Methods
Sodium hyaluronate occurs naturally in vitreous humor, serum, chicken combs, shark skin, and whale cartilage; it is usually extracted and purified from chicken combs. It may also be manufactured by fermentation of selected Streptococcus zooepidemicus bacterial strains; sodium hyaluronate is removed from the fermentation medium by filtration and purified by ultrafiltration. It is then precipitated with an organic solvent and dried.
Application
Sodium Hyaluronic is is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. Sodium hyaluronate is widely used as follows:
antifungal agent.
prevents thromboembolic complications.
aldosterone antagonist used as an adjunct in the management of chronic heart failure.
suitable as substrate for hyaluronidase.
Surgical aid (ophthalmological).
Definition
Sodium Hyaluronate is a polysaccharide of linear and repeating structural units of the disaccharide D-glucuronic acid and N-acetylD-glucosamine. Hyaluronic acid in human body usually present as polymers with several million molecular weight, and the structural difference by the animal species has not been confirmed.
Pharmaceutical Applications
Sodium hyaluronate is the predominant form of hyaluronic acid at
physiological pH. The name hyaluronan is used when the
polysaccharide is mentioned in general terms, and in the literature
the terms hyaluronic acid and sodium hyaluronate are used
interchangeably.
Hyaluronan is used therapeutically to treat osteoarthritis in the
knee, and is an effective treatment for arthritic pain. Crosslinked
hyaluronan gels are used as drug delivery systems.
Hyaluronan is the most common negatively charged glycosaminoglycan
in the human vitreous humor, and is known to interact
with polymeric and liposomal DNA complexes, where hyaluronan
solutions have been shown to decrease the cellular uptake of
complexes.(4) This is useful for enhancing the availability and
retention time of drugs administered to the eye. It is immunoneutral,
which makes it useful for the attachment of biomaterials for use in
tissue engineering and drug delivery systems; it also has important
applications in the fields of vascosurgery and vascosupplementation.
Safety
Sodium hyaluronate is used in cosmetics and in topical, parenteral,
and ophthalmic pharmaceutical formulations. It is generally
regarded as a relatively nontoxic and nonirritant material. Sodium
hyaluronate has been reported to be an experimental teratogen.
LD50 (mouse, IP): 1.5 g/kg
LD50 (rabbit, IP): 1.82 g/kg
LD50 (rat, IP): 1.77 g/kg
storage
Sodium hyaluronate should be stored in a cool, dry place in tightly sealed containers. The powder is stable for 3 years if stored in unopened containers.
Regulatory Status
Included in the FDA Inactive Ingredients Database (topical gel preparation).
Sodium hyaluronate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Fido Pharma | +91-9876274767 +91-9167231289 | Haryana, India | 23 | 58 | Inquiry |
| Godrej Industries Ltd | +919820305315 | Maharashtra, India | 41 | 58 | Inquiry |
| Kumar Organic Products Ltd | +91-9845286706 +91-8041425832 | Karnataka, India | 26 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4317 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
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